Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

(2020) Sreekanth Rajan et al.   Nature Chemical Biology

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs

(2020) Sabine Willems et al.   Communications Chemistry

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

(2020) Paola Munoz-Tello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas

(2019) Keshav Karki et al.   JOURNAL OF NEURO-ONCOLOGY

Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells

(2019) Yangshun Tang et al.   TOXICOLOGY IN VITRO

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

Amodiaquine-induced reproductive toxicity in adult male rats

(2015) Yan-Ru Niu et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

(2015) Chun-Hyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending the Structure–Activity Relationship of Anthranilic Acid Derivatives As Farnesoid X Receptor Modulators: Development of a Highly Potent Partial Farnesoid X Receptor Agonist

(2014) Daniel Merk et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

(2013) Mickael Decressac et al.   Nature Reviews Neurology

Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine

(2012) Soon Goo Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)

(2010) Karen A. Nolan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Candidate Selection and Preclinical Evaluation ofN-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

(2009) Paul M. O’Neill et al.   JOURNAL OF MEDICINAL CHEMISTRY