The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice

Pregnancy Epigenetic Signature in T Helper 17 and T Regulatory Cells in Multiple Sclerosis

(2019) Andrea Iannello et al.   Frontiers in Immunology

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

The miR206-JunD Circuit Mediates the Neurotoxic Effect of Methylmercury in Cortical Neurons

(2018) Natascia Guida et al.   TOXICOLOGICAL SCIENCES

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

(2018) Marina Boido et al.   Frontiers in Cellular Neuroscience

Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation

(2018) Serenella Anzilotti et al.   Cell Death & Disease

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis

(2018) Jason R. Thonhoff et al.   CURRENT OPINION IN NEUROLOGY

Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets

(2018) Rossana Sirabella et al.   Frontiers in Neuroscience

Inflammation in ALS/FTD pathogenesis

(2018) Madelyn E. McCauley et al.   ACTA NEUROPATHOLOGICA

The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases

(2017) Ricardo Rodríguez-Calvo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Association of polymorphisms and reduced expression levels of the NR4A2 gene with Parkinson's disease in a Mexican population

(2017) Elizabeth Ruiz-Sánchez et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

NR4A2 genetic variation and Parkinson's disease: Evidence from a systematic review and meta-analysis

(2017) Hongmei Liu et al.   NEUROSCIENCE LETTERS

Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy

(2017) Antonio Piras et al.   Cell Death & Disease

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury

(2017) Natascia Guida et al.   Frontiers in Neuroscience

Transcriptional modulation of regulatory T cell development by novel regulators NR4As

(2016) Hee Yeon Won et al.   ARCHIVES OF PHARMACAL RESEARCH

Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE

(2016) Ankita Saini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nuclear receptor 4A (NR4A) family – orphans no more

(2016) Stephen Safe et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients

(2016) Francesca Montarolo et al.   NEUROTOXICITY RESEARCH

Nurr1 reduction influences the onset of chronic EAE in mice

(2015) Francesca Montarolo et al.   INFLAMMATION RESEARCH

Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

(2015) L. Formisano et al.   JOURNAL OF NEUROSCIENCE

The dual roles of immunity in ALS: Injury overrides protection

(2015) Benjamin J. Murdock et al.   NEUROBIOLOGY OF DISEASE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Expression of Muscle-Specific MiRNA 206 in the Progression of Disease in a Murine SMA Model

(2015) Valeria Valsecchi et al.   PLoS One

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection

(2014) M J Sisalli et al.   CELL DEATH AND DIFFERENTIATION

Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis

(2014) Marina Boido et al.   CYTOTHERAPY

Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice

(2014) Francesca Montarolo et al.   PLoS One

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Histone H3K27 Trimethylation Inhibits H3 Binding and Function of SET1-Like H3K4 Methyltransferase Complexes

(2013) D.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

The N-Terminal Region of Nurr1 (a.a 1–31) Is Essential for Its Efficient Degradation by the Ubiquitin Proteasome Pathway

(2013) Beatriz Alvarez-Castelao et al.   PLoS One

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

(2013) B. Kadkhodaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention

(2012) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING

Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function

(2012) D García-Pérez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson’s disease

(2012) H. Liu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons

(2012) Olga Baron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nurr1 Protein Is Required forN-Methyl-d-aspartic Acid (NMDA) Receptor-mediated Neuronal Survival

(2012) Bruna Barneda-Zahonero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells

(2012) Yu-Wei Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammation: a role for NR4A orphan nuclear receptors?

(2011) Jason P. McMorrow et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

(2011) Takashi Sekiya et al.   Nature Communications

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

(2010) N. Volakakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors

(2010) Jiaxi Zhou et al.   STEM CELLS

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Decreased NURR1 gene expression in patients with Parkinson's disease

(2008) Weidong Le et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA