Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

(2014) Syng-Ook Lee et al.   MOLECULAR CANCER RESEARCH

Nuclear Import and Export Signals Control the Subcellular Localization of Nurr1 Protein in Response to Oxidative Stress

(2013) Ángel Juan García-Yagüe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease in the nuclear age of neuroinflammation

(2013) Yvonne M. Nolan et al.   TRENDS IN MOLECULAR MEDICINE

Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells

(2012) Xi Li et al.   BIOCHEMICAL PHARMACOLOGY

Late-onset Parkinsonism in NF B/c-Rel-deficient mice

(2012) C. Baiguera et al.   BRAIN

Molecular Pathways: The Role of NR4A Orphan Nuclear Receptors in Cancer

(2012) H. M. Mohan et al.   CLINICAL CANCER RESEARCH

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

(2011) Kyungsil Yoon et al.   CARCINOGENESIS

Targeting NR4A1 (TR3) in cancer cells and tumors

(2011) Syng-Ook Lee et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Phosphorylation of Histone H2A.X as an Early Marker of Neuronal Endangerment following Seizures in the Adult Rat Brain

(2011) S. L. Crowe et al.   JOURNAL OF NEUROSCIENCE

Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons

(2011) James A. Miller et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

(2011) A.R. Carta et al.   NEUROSCIENCE

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson’s disease

(2010) Kathleen A. Maguire-Zeiss et al.   JOURNAL OF NEURAL TRANSMISSION

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes

(2009) Wendy L. Thompson et al.   BRAIN RESEARCH

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

(2009) S. Ghisletti et al.   GENES & DEVELOPMENT

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse

(2009) Z.C. Baquet et al.   NEUROSCIENCE

NeuN is not a reliable marker of dopamine neurons in rat substantia nigra

(2009) Jason R. Cannon et al.   NEUROSCIENCE LETTERS

Decreased NURR1 gene expression in patients with Parkinson's disease

(2008) Weidong Le et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

(2008) T. Inamoto et al.   MOLECULAR CANCER THERAPEUTICS

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

(2008) Roberta Bianchi et al.   NEUROBIOLOGY OF AGING

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

(2007) Ronald B. Tjalkens et al.   JOURNAL OF NEUROSCIENCE RESEARCH