Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

Rapid Electrical Stimulation Increased Cardiac Apoptosis Through Disturbance of Calcium Homeostasis and Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2018) Le Geng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Human Induced Pluripotent Stem Cell–Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers

(2018) Marc D. Lemoine et al.   Circulation-Arrhythmia and Electrophysiology

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Faradaic reactions in capacitive deionization (CDI) - problems and possibilities: A review

(2018) Changyong Zhang et al.   WATER RESEARCH

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

(2018) R. P. Pölönen et al.   Stem Cells International

Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes

(2018) András Horváth et al.   Stem Cell Reports

Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies

(2018) Naim Shaheen et al.   Stem Cell Reports

A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias

(2018) Lukas Clasen et al.   PLoS One

Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

(2018) Rupamanjari Majumder et al.   eLife

Differentiation of cardiomyocytes and generation of human engineered heart tissue

(2017) Kaja Breckwoldt et al.   Nature Protocols

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

(2017) Ilya Y. Shadrin et al.   Nature Communications

Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

(2017) Chang Cui et al.   Stem Cell Research & Therapy

Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

(2017) Hendrik Lapp et al.   Scientific Reports

Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

(2017) Marc D. Lemoine et al.   Scientific Reports

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

(2016) Tobias Bruegmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

(2016) George Eng et al.   Nature Communications

Human Engineered Heart Tissue: Analysis of Contractile Force

(2016) Ingra Mannhardt et al.   Stem Cell Reports

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation

(2016) Claudia Crocini et al.   Scientific Reports

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

(2015) I. Karakikes et al.   CIRCULATION RESEARCH

“Beauty is a light in the heart”: The transformative potential of optogenetics for clinical applications in cardiovascular medicine1

(2015) Patrick M. Boyle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes

(2014) Brian O. Bingen et al.   CARDIOVASCULAR RESEARCH

Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

(2014) Marc N. Hirt et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

(2013) Norbert Jost et al.   JOURNAL OF PHYSIOLOGY-LONDON

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

(2012) Zhenghang Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility

(2012) Adriana Blazeski et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Calsequestrin 2 and arrhythmias

(2011) Michela Faggioni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

A user's guide to channelrhodopsin variants: features, limitations and future developments

(2010) John Y. Lin   EXPERIMENTAL PHYSIOLOGY

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

The role of the Na+/Ca2+ exchanger, INa and ICaL in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts

(2009) Attila S Farkas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block

(2008) William C. Lester et al.   CELL CALCIUM

Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current

(2008) Xiao Yan Qi et al.   CIRCULATION RESEARCH

Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

(2008) Peter Milberg et al.   HEART RHYTHM