Extracellular Vesicles as Promising Carriers in Drug Delivery: Considerations from a Cell Biologist’s Perspective

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

(2021) Rebekah Omarkhail Elliott et al.   Pharmaceutics

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Packaging RNA drugs into extracellular vesicles

(2020) Monique A. J. van Eijndhoven et al.   Nature Biomedical Engineering

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications

(2020) Dimitrios Tsiapalis et al.   Cells

SnapShot: Extracellular Vesicles

(2020) Federico Cocozza et al.   CELL

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

(2020) Wei Hu et al.   Molecular Cancer

ACE2-containing extracellular vesicles and exomeres bind the SARS-CoV-2 spike protein

(2020) Qin Zhang et al.   GASTROENTEROLOGY

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

Extracellular Vesicles: From Biomarkers to Therapeutic Tools

(2020) Simona Bernardi et al.   Biology-Basel

Modern isolation and separation techniques for extracellular vesicles

(2020) Thanaporn Liangsupree et al.   JOURNAL OF CHROMATOGRAPHY A

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus

(2020) Federico Cocozza et al.   Journal of Extracellular Vesicles

Improved loading of plasma derived-extracellular vesicles to encapsulate antitumor miRNAs

(2019) Margherita Alba Carlotta Pomatto et al.   Molecular Therapy-Methods & Clinical Development

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

(2019) Alessandra Ciullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles as drug delivery systems methods of production and potential therapeutic applications

(2019) Magdalena Surman et al.   CURRENT PHARMACEUTICAL DESIGN

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

(2019) Liu Han et al.   Molecular Cancer

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

(2019) Olivier G. de Jong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exosome manufacturing status

(2019) William Whitford et al.   Future Medicinal Chemistry

Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome

(2019) Carolina Balbi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

(2019) Kyle I. Mentkowski et al.   Scientific Reports

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

(2019) Xiaowei Bian et al.   Stem Cell Research & Therapy

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Extracellular Vesicles and Metastasis

(2019) Shizhen Emily Wang   Cold Spring Harbor Perspectives in Medicine

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?

(2019) Jorge Diego Martin-Rufino et al.   Frontiers in Bioengineering and Biotechnology

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A

(2018) Lucio Barile et al.   CARDIOVASCULAR RESEARCH

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ESCRT-dependent cargo sorting at multivesicular endosomes

(2018) E.B. Frankel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

(2018) Gabriella Andriolo et al.   Frontiers in Physiology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Editorial: The Immunomodulatory Properties of Extracellular Vesicles From Pathogens, Immune Cells, and Non-immune Cells

(2018) Ivan K. H. Poon et al.   Frontiers in Immunology

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

Exosomes: From Garbage Bins to Promising Therapeutic Targets

(2017) Mohammed H. Rashed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents

(2017) Verena Börger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

(2017) Akihiro Matsumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis

(2017) Yuxian Song et al.   STEM CELLS

Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

(2017) Nicholas L. Syn et al.   TRENDS IN BIOTECHNOLOGY

Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes

(2017) Germana Rappa et al.   Oncotarget

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

(2017) Carolina Balbi et al.   Stem Cells Translational Medicine

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

(2017) Claudia Lo Sicco et al.   Stem Cells Translational Medicine

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

(2017) Jinyun Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

(2017) Wei Jiang Goh et al.   Scientific Reports

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

(2016) Jingwei Ma et al.   CELL RESEARCH

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Role of Alix in miRNA packaging during extracellular vesicle biogenesis

(2016) ALESSANDRA IAVELLO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

(2016) Sander A.A. Kooijmans et al.   PHARMACOLOGICAL RESEARCH

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Derived fromAkt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

(2016) Jie Ma et al.   Stem Cells Translational Medicine

Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing

(2016) Shuo Fang et al.   Stem Cells Translational Medicine

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Trehalose prevents aggregation of exosomes and cryodamage

(2016) Steffi Bosch et al.   Scientific Reports

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

(2015) Krishna M. Panchalingam et al.   Stem Cell Research & Therapy

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

(2014) Yuliang Feng et al.   PLoS One

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response

(2014) Reuben Saba et al.   Frontiers in Immunology

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury

(2012) Xiaohui Wang et al.   CARDIOVASCULAR RESEARCH

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model

(2012) JUAN HE et al.   NEPHROLOGY

MicroRNA-146a modulates TGF-β1-induced phenotypic differentiation in human dermal fibroblasts by targeting SMAD4

(2011) Zhen Liu et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

miR-146a is modulated in human endothelial cell with aging

(2011) Mariuca Vasa-Nicotera et al.   ATHEROSCLEROSIS

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

(2011) Qiuwei Pan et al.   GUT

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

(2011) Han-Soo Kim et al.   JOURNAL OF PROTEOME RESEARCH

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

(2011) Scott D. Olson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction–Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct Apoptosis

(2010) David W. Infanger et al.   CIRCULATION RESEARCH

Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

(2010) Isotta Chimenti et al.   CIRCULATION RESEARCH

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Lateral organization of membrane proteins: tetraspanins spin their web

(2009) Stéphanie Charrin et al.   BIOCHEMICAL JOURNAL

Cardiac regeneration and stem cell therapy

(2008) Joshua M Hare et al.   Current Opinion in Organ Transplantation

Cell therapy for bone regeneration-Bench to bedside

(2008) Kevin Lee et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE