The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
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Title
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
Authors
Keywords
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Journal
Cell Death Discovery
Volume 7, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-03-15
DOI
10.1038/s41420-021-00432-0
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Note: Only part of the references are listed.- A robust TDP-43 knock-in mouse model of ALS
- (2020) Shih-Ling Huang et al. Acta Neuropathologica Communications
- LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
- (2019) Benjamin Scott Padman et al. Nature Communications
- Repeated Low-Level Blast Overpressure Leads to Endovascular Disruption and Alterations in TDP-43 and Piezo2 in a Rat Model of Blast TBI
- (2019) Lanier Heyburn et al. Frontiers in Neurology
- TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
- (2018) Matthew A. White et al. NATURE NEUROSCIENCE
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway
- (2018) Dawei Lei et al. Oncotarget
- Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin
- (2018) Ghanshyam Swarup et al. Frontiers in Immunology
- Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line
- (2018) Myoung Sup Shim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2
- (2018) Zhengbo Shao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study
- (2018) Margaret E. Flanagan et al. JOURNAL OF ALZHEIMERS DISEASE
- Prevalence of Normal-Tension Glaucoma in the Chinese Population: A Systematic Review and Meta-Analysis
- (2018) Jing Zhao et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein
- (2017) Megha Bansal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathology of Neurodegenerative Diseases
- (2017) Brittany N. Dugger et al. Cold Spring Harbor Perspectives in Biology
- Endothelial-Monocyte Activating Polypeptide II Suppresses the In Vitro Glioblastoma-Induced Angiogenesis by Inducing Autophagy
- (2017) Zhiqing Li et al. Frontiers in Molecular Neuroscience
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
- (2016) Han-Jou Chen et al. BRAIN
- Familial Amyotrophic Lateral Sclerosis-linked Mutations inProfilin 1Exacerbate TDP-43-induced Degeneration in the Retina ofDrosophila melanogasterthrough an Increase in the Cytoplasmic Localization of TDP-43
- (2016) Koji Matsukawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Significance of optineurin mutations in glaucoma and other diseases
- (2016) Yuriko Minegishi et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Cellular Functions of Optineurin in Health and Disease
- (2016) Karolina Slowicka et al. TRENDS IN IMMUNOLOGY
- Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
- (2016) Seshiru Nakazawa et al. Nature Communications
- Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration
- (2016) Myoung Sup Shim et al. Scientific Reports
- Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
- (2015) Hongyu Ying et al. BMC CELL BIOLOGY
- Visual impairment in an optineurin mouse model of primary open-angle glaucoma
- (2015) Henry C. Tseng et al. NEUROBIOLOGY OF AGING
- Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy
- (2015) Angèle Nalbandian et al. PLoS One
- Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
- (2014) E. L. Scotter et al. JOURNAL OF CELL SCIENCE
- Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD
- (2014) Michael E. Ward et al. JOURNAL OF EXPERIMENTAL MEDICINE
- E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy
- (2014) Madhavi Latha Somaraju Chalasani et al. PLoS One
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response
- (2014) Tao Zhang et al. PLoS Genetics
- RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
- (2013) Ryoko Ihara et al. HUMAN MOLECULAR GENETICS
- Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma
- (2013) Yuriko Minegishi et al. HUMAN MOLECULAR GENETICS
- Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster
- (2012) I Pimenta de Castro et al. CELL DEATH AND DIFFERENTIATION
- Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis
- (2012) S. Yamashita et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina
- (2011) Qingfeng Meng et al. MOLECULAR BIOLOGY REPORTS
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- (2011) P. Wild et al. SCIENCE
- Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice
- (2010) Zai-Long Chi et al. HUMAN MOLECULAR GENETICS
- Mutations of optineurin in amyotrophic lateral sclerosis
- (2010) Hirofumi Maruyama et al. NATURE
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