Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

(2014) Zhengzhao Liu et al.   CANCER CELL

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effects of mutations and deletions in the human optineurin gene

(2014) Sanja Turturro et al.   SpringerPlus

Structural basis for phosphorylation-triggered autophagic clearance ofSalmonella

(2013) Vladimir V. Rogov et al.   BIOCHEMICAL JOURNAL

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Common Pathway for a Rare Disease?

(2013) S. B. Vafai et al.   SCIENCE

Optineurin

(2012) David Kachaner et al.   CELL CYCLE

Current understanding of conventional outflow dysfunction in glaucoma

(2012) W. Daniel Stamer et al.   CURRENT OPINION IN OPHTHALMOLOGY

Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway

(2012) Qingfeng Meng et al.   MOLECULAR BIOLOGY REPORTS

Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression

(2012) David Kachaner et al.   MOLECULAR CELL

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

Differential Involvement of Optineurin in Amyotrophic Lateral Sclerosis With or Without SOD1 Mutations

(2011) Han-Xiang Deng   ARCHIVES OF NEUROLOGY

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

(2011) Ananthamurthy Nagabhushana et al.   PLoS One

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

(2010) Ananthamurthy Nagabhushana et al.   BMC CELL BIOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The majority of the genetic risk for Paget’s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes

(2010) Pui Yan Jenny Chung et al.   HUMAN GENETICS

Processing of Optineurin in Neuronal Cells

(2010) Xiang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma Gene

(2010) Hongyu Ying et al.   PLoS One

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

(2010) Shannon E. Boye et al.   PLoS One

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin

(2010) BumChan Park et al.   PLoS One

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

(2010) Jamel Mankouri et al.   PLoS Pathogens

Differential Effects of Myocilin and Optineurin, Two Glaucoma Genes, on Neurite Outgrowth

(2009) Takahisa Koga et al.   AMERICAN JOURNAL OF PATHOLOGY

Individual molecular response to elevated intraocular pressure in perfused postmortem human eyes

(2009) Núria Comes et al.   PHYSIOLOGICAL GENOMICS

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

(2009) Cherukuri Sudhakar et al.   PLoS One

The genetics of primary open-angle glaucoma: A review

(2008) R. Rand Allingham et al.   EXPERIMENTAL EYE RESEARCH

Activation of autophagy in retinal ganglion cells

(2008) Seok Hwan Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Focus on Molecules: Optineurin

(2007) Madhavi Latha Chalasani et al.   EXPERIMENTAL EYE RESEARCH