The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

(2021) Xing Yi Woo et al.   NATURE GENETICS

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

(2020) Alvin Kamili et al.   BRITISH JOURNAL OF CANCER

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma

(2020) Rosa Nguyen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma

(2020) Lucas Moreno et al.   EUROPEAN JOURNAL OF CANCER

Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

(2020) Karin Hansson et al.   Science Translational Medicine

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

(2020) Xin Cui et al.   eLife

Organ-on-a-Chip: A New Paradigm for Drug Development

(2020) Chao Ma et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

(2019) Renata Sano et al.   Science Translational Medicine

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

(2019) Chuan Yan et al.   CELL

Anti‐tumor effects of PIM / PI 3K/ mTOR triple kinase inhibitor IBL ‐302 in neuroblastoma

(2019) Sofie Mohlin et al.   EMBO Molecular Medicine

Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma

(2019) Rosa Nguyen et al.   CLINICAL CANCER RESEARCH

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations

(2019) Sally L. George et al.   EUROPEAN JOURNAL OF CANCER

Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models

(2019) Okada et al.   Cells

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

(2019) P. Fusco et al.   BMC CANCER

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

(2019) Ricky M. Trigg et al.   Nature Communications

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

(2019) Jo Lynne Rokita et al.   Cell Reports

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

(2018) Maurizio Callari et al.   BMC GENOMICS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

(2018) Jenny Karlsson et al.   NATURE GENETICS

Reconsidering the Need for Reconsent at 18

(2018) Benjamin E. Berkman et al.   PEDIATRICS

Research Consent at the Age of Majority: Preferable but not Obligatory

(2018) Kyle B. Brothers et al.   PEDIATRICS

RAS-MAPK pathway-driven tumor progression is associated with loss of CIC and other genomic aberrations in neuroblastoma

(2018) Thomas F Eleveld et al.   CANCER RESEARCH

Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma

(2018) Noémie Braekeveldt et al.   CANCER RESEARCH

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

(2018) Maria P. Ikonomopoulou et al.   Scientific Reports

IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

(2018) Meili Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

(2018) Bieke Decaesteker et al.   Nature Communications

The Avatar Acceptability Study: Survivor, Parent and Community Willingness to Use Patient-Derived Xenografts to Personalize Cancer Care

(2018) C.E. Wakefield et al.   EBioMedicine

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Implications of cancer evolution for drug development

(2017) Samra Turajlic et al.   NATURE REVIEWS DRUG DISCOVERY

MYCN induces neuroblastoma in primary neural crest cells

(2017) R R Olsen et al.   ONCOGENE

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Quo natas, Danio?—Recent Progress in Modeling Cancer in Zebrafish

(2017) Stefanie Kirchberger et al.   Frontiers in Oncology

Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma

(2016) Marie Regairaz et al.   AMERICAN JOURNAL OF PATHOLOGY

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours

(2016) Noémie Braekeveldt et al.   CANCER LETTERS

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Implementation of mechanism of action biology-driven early drug development for children with cancer

(2016) Andrew D.J. Pearson et al.   EUROPEAN JOURNAL OF CANCER

US cancer institute to overhaul tumour cell lines

(2016) Heidi Ledford   NATURE

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts

(2016) Jad El-Hoss et al.   Oncotarget

Generating trunk neural crest from human pluripotent stem cells

(2016) Miller Huang et al.   Scientific Reports

Neuroblastoma

(2016) Katherine K. Matthay et al.   Nature Reviews Disease Primers

Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents

(2015) Michiel Kroesen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma

(2015) K. Krytska et al.   CLINICAL CANCER RESEARCH

Development and characterization of a human orthotopic neuroblastoma xenograft

(2015) Elizabeth Stewart et al.   DEVELOPMENTAL BIOLOGY

The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease

(2015) Melanie L. Graham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

T Cell Expansion Is the Limiting Factor of Virus Control in Mice with Attenuated TCR Signaling: Implications for Human Immunodeficiency

(2015) Kristina M. Hillen et al.   JOURNAL OF IMMUNOLOGY

Mutational dynamics between primary and relapse neuroblastomas

(2015) Alexander Schramm et al.   NATURE GENETICS

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Mouse hospital and co-clinical trial project—from bench to bedside

(2015) John G. Clohessy et al.   Nature Reviews Clinical Oncology

Gammaherpesvirus Small Noncoding RNAs Are Bifunctional Elements That Regulate Infection and Contribute to Virulence In Vivo

(2015) Kevin W. Diebel et al.   mBio

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

(2015) Linda Holmquist Mengelbier et al.   Nature Communications

Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors

(2015) Gennadiy Bondarenko et al.   NEOPLASIA

Functional Sphere Profiling Reveals the Complexity of Neuroblastoma Tumor-Initiating Cell Model

(2015) Aurélie Coulon et al.   NEOPLASIA

ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma

(2014) Scott C. Bresler et al.   CANCER CELL

Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours

(2014) Noémie Braekeveldt et al.   INTERNATIONAL JOURNAL OF CANCER

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

PyClone: statistical inference of clonal population structure in cancer

(2014) Andrew Roth et al.   NATURE METHODS

Orthotopic models of pediatric brain tumors in zebrafish

(2014) C J Eden et al.   ONCOGENE

Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance

(2014) David J. Monsma et al.   PEDIATRIC BLOOD & CANCER

The Impact of the Immune System on Tumor: Angiogenesis and Vascular Remodeling

(2014) Christian Stockmann et al.   Frontiers in Oncology

Lung adenocarcinoma in the era of targeted therapies: histological classification, sample prioritization, and predictive biomarkers

(2013) E. Conde et al.   Clinical & Translational Oncology

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours

(2013) Laurel T. Bate-Eya et al.   EUROPEAN JOURNAL OF CANCER

Directed differentiation of human pluripotent cells to neural crest stem cells

(2013) Laura Menendez et al.   Nature Protocols

Establishment of a patient-derived Wilms' tumor xenograft model: A promising tool for individualized cancer therapy

(2013) Mohammad-Javad Mohseni et al.   Journal of Pediatric Urology

Xenome--a tool for classifying reads from xenograft samples

(2012) T. Conway et al.   BIOINFORMATICS

Procurement of Human Tissues for Research Banking in the Surgical Pathology Laboratory: Prioritization Practices at Washington University Medical Center

(2011) Sandra A. McDonald et al.   BIOPRESERVATION AND BIOBANKING

High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

(2011) J. H. Schulte et al.   CLINICAL CANCER RESEARCH

Preclinical Models for Neuroblastoma: Establishing a Baseline for Treatment

(2011) Tal Teitz et al.   PLoS One

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project

(2011) Hervé J. Brisse et al.   RADIOLOGY

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

(2010) Gudrun Schleiermacher et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

(2010) Alice L. Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report

(2008) Susan L. Cohn et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma

(2008) W. Maes et al.   JOURNAL OF NEURO-ONCOLOGY