Article
Chemistry, Medicinal
Bo Deng, Xiao-Li Jiang, Zhang-Bin Tan, Min Cai, Sui-Hui Deng, Wen-Jun Ding, You-Cai Xu, Yu-Ting Wu, Shuang-Wei Zhang, Rui-Xue Chen, Jun Kan, En-Xin Zhang, Bin Liu, Jing-Zhi Zhang
Summary: This study demonstrated that Dauricine (Dau) inhibits proliferation and promotes cell death in melanoma cells by inhibiting the Src/STAT3 pathways. Molecular docking, dynamics simulations, and surface plasmon resonance imaging further supported the strong binding affinity of Dau to Src, and its effectiveness in suppressing melanoma growth in vivo.
PHYTOTHERAPY RESEARCH
(2021)
Article
Oncology
Youqun Tang, Yanming Cao
Summary: The study confirmed that SOX10 is an oncogene in melanoma, promoting cell proliferation by activating the Notch signaling pathway. High expression of SOX10 is negatively correlated with the prognosis of melanoma patients, suggesting potential therapeutic effects by targeting the SOX10/Notch axis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yousef Salama, Nidal Jaradat, Koichi Hattori, Beate Heissig
Summary: ALOC-EO has an anti-tumor effect on melanoma growth and tumor cell migration by blocking EGFR and ERK1/2 signaling pathways, enhancing its efficacy as a monotherapy or in combination with myelosuppressive drugs in melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Miriam Doepner, Inyoung Lee, Christopher A. Natale, Roderick Brathwaite, Swati Venkat, Sung Hoon Kim, Yiliang Wei, Christopher R. Vakoc, Brian C. Capell, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Michael E. Feigin, Todd W. Ridky
Summary: Research reveals that differences in DOPA synthesis between dark and light melanocytes play a role in regulating melanocyte and melanoma cell proliferation. Inhibiting CHRM1 or FOXM1 could be a potential new therapeutic approach for melanoma.
Article
Biochemistry & Molecular Biology
Yefei Huang, Zixuan Liu, Lingling Li, Min Jiang, Yu Tang, Li Zhou, Jing Li, Yansu Chen
Summary: Sesamin inhibits hypoxia-induced colorectal cancer angiogenesis via the NF-kappa B/HIF-1 alpha/VEGFA signaling pathway. Sesamin significantly suppressed hypoxia-stimulated CRC angiogenesis both in vitro and in vivo. This study provides a theoretical and experimental basis for the use of sesamin in the prevention and treatment of CRC.
Article
Cell Biology
Yazhen Xu, Bingyu Guo, Xiaoyan Liu, Kai Tao
Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.
Article
Multidisciplinary Sciences
Duoli Zhang, Tao Zou, Qingsong Liu, Jie Chen, Mintao Xiao, Anfu Zheng, Zhuo Zhang, Fukuan Du, Yalan Dai, Shixin Xiang, Xu Wu, Mingxing Li, Yu Chen, Yueshui Zhao, Jing Shen, Guiquan Chen, Zhangang Xiao
Summary: METTL7A, a protein-coding gene associated with methylation, has been found to play an important role in tumor progression and tumorigenicity through the p53 signaling pathway.
Article
Integrative & Complementary Medicine
Xue Wang, Xuebing Zhou, Ludan Zhang, Xin Zhang, Chunyu Yang, Yingshi Piao, Jinhua Zhao, Lili Jin, Guihua Jin, Renbo An, Xiangshan Ren
Summary: This study revealed that crowberry inhibits proliferation and migration of CCA cells, induces apoptosis, and achieves these effects by downregulating DEK and Akt signaling pathway.
Article
Pharmacology & Pharmacy
Yangyang Guo, Yanyi Xiao, Hengyue Zhu, Hangcheng Guo, Ying Zhou, Yangping Shentu, Chenfei Zheng, Chaosheng Chen, Yongheng Bai
Summary: The study demonstrated that ATL-1 inhibits the myofibroblastic phenotype and fibrosis development in the kidneys by targeting fibroblast-myofibroblast differentiation and epithelial-mesenchymal transition. This anti-fibrotic effect of ATL-1 is associated with the inhibition of proliferation-linked cascades signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yue Li, Ben Wu, Md Jakir Hossain, Lily Quagliata, Connor O'Meara, Marc R. Wilkins, Susan Corley, Levon M. Khachigian
Summary: Immune checkpoint inhibitors have transformed the treatment of various cancers, but the response rates are still unsatisfactory for many patients and there are no approved small molecule inhibitors of the PD-1/PD-L1 system. In this study, it was found that Flubendazole (FLU) can inhibit melanoma growth and suppress the expression of PD-1 protein. FLU's suppression of PD-1 was accompanied by increased infiltration of CD3(+) T cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yunlong Guo, Wenli Shi, Ruihua Fang
Summary: This study demonstrates that miR-18a-5p regulates proliferation, apoptosis, and autophagy in melanoma cells by targeting the EPHA7 gene. Inhibition of miR-18a-5p suppresses cell proliferation and induces apoptosis and autophagy, while overexpression of EPHA7 reverses these effects. This research provides insight into the role of miRNAs in the pathogenesis of melanoma.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, Research & Experimental
Jiali Shi, Shanshan Sun, Shuqiao Xing, Changgang Huang, Yuqian Huang, Qian Wang, Xiumin Xue, Zhichao Chen, Yongjie Wang, Zhihui Huang
Summary: Fraxinellone was found to inhibit the proliferation and growth of GBM cells in vitro, as well as suppress their migration and induce apoptosis. The mechanism of action involved the downregulation of SIRT3 signaling and the inhibition of GBM tumorigenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Shanshan Sun, Jiali Shi, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie, Yongjie Wang, Zhihui Huang
Summary: Atractylon can inhibit proliferation and migration, as well as induce apoptosis in GBM cells by up-regulating SIRT3, suggesting it as a potential strategy for the treatment of GBM.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kun Zhang, Chunfang Yu, Ruoxi Tian, Wancong Zhang, Shijie Tang, Guiying Wang
Summary: This study found that PAX3 is overexpressed in SKCM and is associated with poor prognosis. Knockdown of PAX3 inhibits proliferation, invasion, and migration of SKCM cells and reverses tumor cell EMT. PAX3 may serve as a potential therapeutic target and prognostic biomarker for SKCM.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alberto Martin, Carolina Epifano, Borja Vilaplana-Marti, Ivan Hernandez, Rocio I. R. Macias, Angel Martinez-Ramirez, Ana Cerezo, Pablo Cabezas-Sainz, Maria Garranzo-Asensio, Sandra Amarilla-Quintana, Deborah Gomez-Dominguez, Eduardo Caleiras, Jordi Camps, Gonzalo Gomez-Lopez, Marta Gomez de Cedron, Ana Ramirez de Molina, Rodrigo Barderas, Laura Sanchez, Susana Velasco-Miguel, Ignacio Perez de Castro
Summary: Despite being frequently observed in cancer cells, chromosomal instability (CIN) and aneuploidy have adverse effects on cellular homeostasis. Epitranscriptomic marks catalyzed by RNA-modifying enzymes change under stress, but their association with aneuploidy is still unknown. TRMT61B, a mitochondrial RNA methyltransferase enzyme, is found to be associated with high levels of aneuploidy in cancer cells. Depletion of TRMT61B induces senescence in cells with low aneuploidy, and apoptosis in cells with high aneuploidy. These findings suggest TRMT61B as a potential biomarker for targeting highly aneuploid tumors.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Respiratory System
Carla Colombo, Grant A. Ramm, Anders Lindblad, Fabiola Corti, Luigi Porcaro, Federico Alghisi, Irina Asherova, Helen Evans, Nataliya Kashirskaya, Elena Kondratyeva, Peter J. Lewindon, Isabelle de Monestrol, Mark Oliver, Chee Y. Ooi, Rita Padoan, Sahana Shankar, Gianfranco Alicandro
Summary: Cystic-fibrosis-related liver disease (CFLD) is a variable phenotype of CF. CFTR modulator therapies, elexacaftor, tezacaftor, and ivacaftor (ETI), and ivacaftor (IVA), are available for CF patients. Genetic eligibility evaluation showed that 13% of patients without CFLD and 11% of patients with severe CFLD are not eligible for ETI or IVA therapy. Ineligible patients cannot benefit from these new treatments.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Multidisciplinary Sciences
Nidia de Sousa, Diego Robledo, Laura Gonzalez-Llera, Andreia G. Pinho, Diogo J. Santos, Susana Monteiro, Jonas Campos, Jorge R. Cibrao, Nuno A. Silva, Laura Sanchez, Antonio J. Salgado, Anton Barreiro-Iglesias
Summary: Spinal cord injury (SCI) has no available pharmacological treatments for promoting neurological recovery. Baclofen treatment has been shown to promote functional recovery in mice with compression SCI. This study provides transcriptomic data from adult mouse spinal cords collected 7 days after compression SCI and baclofen administration. The data includes raw RNA-seq data and bioinformatic analyses.
Article
Toxicology
Eric March-Vila, Giacomo Ferretti, Emma Terricabras, Ines Ardao, Jose Manuel Brea, Maria Jose Varela, Alvaro Arana, Juan Andres Rubiolo, Ferran Sanz, Maria Isabel Loza, Laura Sanchez, Hector Alonso, Manuel Pastor
Summary: In order to reduce the impact of human activity on the environment, many industries in the leather and textile sector are adopting measures to characterize the chemical safety of substances commonly used in their processes. This study compiles and annotates the substances used in this sector, using a combination of data collection, experimental methods, and in silico predictions. The results show that in silico methods can provide reasonably good hazard estimations and fill knowledge gaps in the chemical space of the leather and textile industry.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lorena Carmona-Rodriguez, Aaron S. Gajadhar, Irene Blazquez-Garcia, Laura Guerrero, Manuel A. Fernandez-Rojo, Iker Uriarte, Maricruz Mamani-Huanca, Angeles Lopez-Gonzalvez, Sergio Ciordia, Antonio Ramos, Jose Ignacio Herrero, Maite G. Fernandez-Barrena, Maria Arechederra, Carmen Berasain, Jorge Quiroga, Bruno Sangro, Josepmaria Argemi, Fernando Pardo, Fernando Rotellar, Daniel Lopez, Coral Barbas, Matias A. Avila, Fernando J. Corrales
Summary: The liver is capable of regenerating itself after injury or partial hepatectomy, representing a therapeutic opportunity for liver disease patients. However, the causes of failed liver regeneration are still poorly understood. In this study, the regulation of liver proteome and phosphoproteome after partial hepatectomy was investigated in mice, providing detailed mechanisms of the early phase of liver regeneration. Additionally, the dynamic changes of serum proteome and metabolome in healthy liver transplant donors were analyzed. The results provide insights into the cellular processes orchestrating liver regeneration and may be useful for monitoring the regenerative process and preventing complications associated with liver resection.
Editorial Material
Gastroenterology & Hepatology
Darrell H. G. Crawford, Grant A. Ramm, Kim R. Bridle, Amanda J. Nicoll, Martin B. Delatycki, John K. Olynyk
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Shruti Sakhuja, Heather M. Staples, Charles G. Minard, Louise E. Ramm, Peter J. Lewindon, Grant A. Ramm, Daniel H. Leung
Summary: This study aimed to evaluate the clinical utility of lung function and liver biomarkers assessed years prior to liver biopsy-proven CFLD in predicting the risk of severe fibrosis development. The findings suggest that mild-moderate pulmonary dysfunction and higher liver biomarker indices at baseline may be associated with faster progression of CFLD.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Daniel Dashevsky, Kate Baumann, Eivind A. B. Undheim, Amanda Nouwens, Maria P. Ikonomopoulou, Justin O. Schmidt, Lilin Ge, Hang Fai Kwok, Juanita Rodriguez, Bryan G. Fry
Summary: Aculeate hymenopterans use venom for different purposes based on social behavior, with solitary species using it to paralyze prey and social species using it for colony defense. This study found that venom compositions and activities vary among species, with social species having higher presence of peptides causing damage and pain.
Article
Neurosciences
Ana Quelle-Regaldie, Nerea Gandoy-Fieiras, Paula Rodriguez-Villamayor, Sandra Maceiras, Ana Paula Losada, Monica Folgueira, Pablo Cabezas-Sainz, Anton Barreiro-Iglesias, Maria Villar-Lopez, Maria Isabel Quiroga-Berdeal, Laura Sanchez, Maria Jesus Sobrido
Summary: Niemann Pick disease type C (NPC) is a neurodegenerative disorder characterized by lipid accumulation, and a zebrafish model has been generated to study the disease. The NPC1 mutant larvae showed high lethality, impaired motor function, and lipid accumulation in different organs. RNAseq analysis revealed differentially expressed genes related to neurodevelopment, lipid metabolism, muscle contraction, and other processes. This new zebrafish model provides a valuable tool for studying the cellular and molecular mechanisms of NPC and for exploring new treatments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Oncology
N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Kohn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker
Summary: The TWEAK/Fn14 signalling pathway plays a crucial role in tissue injury and regeneration, and its involvement in pancreatic injury and cancer is not well understood. This study demonstrates that TWEAK/Fn14 signalling is important in the establishment and progression of chronic pancreatitis, increasing the risk of pancreatic cancer. The findings suggest the TWEAK/Fn14 pathway as a potential therapeutic target.
Article
Pharmacology & Pharmacy
Axel Kattar, Ana Quelle-Regaldie, Laura Sanchez, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The aim of this study was to develop cationic niosomes for the ocular delivery of epalrestat, a drug used in the treatment of diabetic eye damage. The niosomes were characterized and found to have a size of 80 nm, a charge ranging from -23 to +40 mV, and a spherical shape. The encapsulation efficiency of the niosomes was 99.76% and they showed a sustained release of the drug over 20 days. The niosomes were non-irritating, non-toxic, and showed higher permeation in the sclera compared to the unencapsulated drug.
Article
Biochemical Research Methods
Andrew A. Walker, Lynda E. Perkins, Andrea Battisti, Myron P. Zalucki, Glenn F. King
Summary: Ochrogaster lunifer is an Australian caterpillar that has detachable urticating setae with defensive function. These setae can cause inflammation on human skin and equine foetal loss syndrome in gravid horses if accidentally ingested. Transcriptomics and proteomics analysis identified 37 putative toxins, including multiple homologues of honeybee venom peptide secapin and proteins with similarity to odorant binding proteins, arylphorins, and the insect immune modulator Diedel. This study reveals candidate molecules that may contribute to the adverse effects of processionary caterpillar setae on human and animal health.
Article
Food Science & Technology
Bianca Op den Brouw, Manuel A. Fernandez-Rojo, Tom Charlton, Bryan G. Fry, Maria P. Ikonomopoulou
Summary: Snake venoms vary in composition depending on geographical location, age, and prey. Understanding the evolution of animal venoms has contributed to the discovery of potential drug candidates. The venom of king cobras differs between populations and age groups. Malaysian king cobra venoms are more cytotoxic than Chinese king cobra venoms.