Reproducible In Vitro Tissue Culture Model to Study Basic Mechanisms of Calcific Aortic Valve Disease: Comparative Analysis to Valvular Interstitials Cells

Molecular mechanisms involved in high glucose‐induced valve calcification in a 3D valve model with human valvular cells

(2020) Mihaela Vadana et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve

(2020) Letitia Ciortan et al.   Polymers

Native aortic valve derived extracellular matrix hydrogel for three dimensional culture analyses with improved biomimetic properties

(2019) Laura Nehrenheim et al.   Biomedical Materials

Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves

(2019) M Victoria Gomez-Stallons et al.   HEART

Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance

(2019) Julia C. Fontoura et al.   Materials Science & Engineering C-Materials for Biological Applications

Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

(2018) Florian Schlotter et al.   CIRCULATION

Enzymes of the purinergic signaling system exhibit diverse effects on the degeneration of valvular interstitial cells in a 3-D microenvironment

(2018) Andreas Weber et al.   FASEB JOURNAL

Timing of intervention in aortic stenosis: a review of current and future strategies

(2018) Russell James Everett et al.   HEART

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

A Contemporary Review of Severe Aortic Stenosis

(2018) Heath SL Adams et al.   INTERNAL MEDICINE JOURNAL

Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells

(2018) Maria Bogdanova et al.   Frontiers in Physiology

Endothelial to mesenchymal transformation is induced by altered extracellular matrix in aortic valve endothelial cells

(2017) Sudip Dahal et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Reproducible in vitro model for dystrophic calcification of cardiac valvular interstitial cells: insights into the mechanisms of calcific aortic valvular disease

(2017) Heather A. Cirka et al.   LAB ON A CHIP

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

(2017) Arkady Rutkovskiy et al.   Journal of the American Heart Association

Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures

(2017) Ana M. Porras et al.   Journal of the American Heart Association

Design of biomimetic cellular scaffolds for co-culture system and their application

(2017) Yun-Min Kook et al.   Journal of Tissue Engineering

Medical Treatment of Aortic Stenosis

(2016) Guillaume Marquis-Gravel et al.   CIRCULATION

Calcific aortic stenosis

(2016) Brian R. Lindman et al.   Nature Reviews Disease Primers

Calcific Aortic Valve Disease Is Associated with Layer-Specific Alterations in Collagen Architecture

(2016) Heather N. Hutson et al.   PLoS One

Valvular interstitial cells suppress calcification of valvular endothelial cells

(2015) Jesper Hjortnaes et al.   ATHEROSCLEROSIS

In vitro models of aortic valve calcification: solidifying a system

(2015) Meghan A. Bowler et al.   CARDIOVASCULAR PATHOLOGY

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic ValveCLINICAL PERSPECTIVE

(2015) Rihab Bouchareb et al.   CIRCULATION

Calcific Aortic Valve Disease

(2014) Katherine E. Yutzey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluation of a porcine model of early aortic valve sclerosis

(2014) Krista L. Sider et al.   CARDIOVASCULAR PATHOLOGY

The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

(2014) Wenjing Yu et al.   Current Stem Cell Research & Therapy

Heterogeneous Susceptibility of Valve Endothelial Cells to Mesenchymal Transformation in Response to TNFα

(2013) Emily J. Farrar et al.   ANNALS OF BIOMEDICAL ENGINEERING

Studying cell-cell communication in co-culture

(2013) Danielle R. Bogdanowicz et al.   Biotechnology Journal

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease

(2013) Kevin Bosse et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

Calcific Aortic Stenosis

(2012) Marc R. Dweck et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

(2011) Jordan D. Miller et al.   CIRCULATION RESEARCH

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments

(2010) Karien J. Rodriguez et al.   MATRIX BIOLOGY

Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential

(2009) Jan-Hung Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

(2008) M. Schoppet et al.   KIDNEY INTERNATIONAL