Reproducible in vitro model for dystrophic calcification of cardiac valvular interstitial cells: insights into the mechanisms of calcific aortic valvular disease

Active Traction Force Response to Long-Term Cyclic Stretch Is Dependent on Cell Pre-stress

(2016) Heather Cirka et al.   BIOPHYSICAL JOURNAL

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation

(2016) Jesper Hjortnaes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates

(2015) Shijie He et al.   BIOPHYSICAL JOURNAL

Biophysical Analysis of Dystrophic and Osteogenic Models of Valvular Calcification

(2015) Joseph Chen et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation

(2014) Sarah T. Gould et al.   BIOMATERIALS

Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis

(2013) Amanda L. Clement et al.   Acta Biomaterialia

Side-Specific Endothelial-Dependent Regulation of Aortic Valve Calcification

(2013) Jennifer Richards et al.   AMERICAN JOURNAL OF PATHOLOGY

Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand

(2013) Antonella Galeone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism

(2013) Rihab Bouchareb et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

(2013) Sergio Bertazzo et al.   NATURE MATERIALS

Monolayer Stress Microscopy: Limitations, Artifacts, and Accuracy of Recovered Intercellular Stresses

(2013) Dhananjay T. Tambe et al.   PLoS One

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

(2013) A. F. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular stresses in patterned cell assemblies

(2013) Michel Moussus et al.   Soft Matter

The Role of TNF-αand TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease

(2013) Antonella Galeone et al.   TheScientificWorldJOURNAL

Mechanisms of Calcification in Aortic Valve Disease: Role of Mechanokinetics and Mechanodynamics

(2013) W. David Merryman et al.   Current Cardiology Reports

Small peptide functionalized thiol–ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition

(2012) Sarah T. Gould et al.   Acta Biomaterialia

Cadherin-11 Regulates Cell–Cell Tension Necessary for Calcific Nodule Formation by Valvular Myofibroblasts

(2012) Joshua D. Hutcheson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calcific nodule morphogenesis by heart valve interstitial cells is strain dependent

(2012) Charles I. Fisher et al.   Biomechanics and Modeling in Mechanobiology

Scaling of Traction Forces with the Size of Cohesive Cell Colonies

(2012) Aaron F. Mertz et al.   PHYSICAL REVIEW LETTERS

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

(2012) Huan Wang et al.   PLoS One

Characterization of Porcine Aortic Valvular Interstitial Cell ‘Calcified’ Nodules

(2012) Kristy L. Cloyd et al.   PLoS One

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Baseline Severity of Aortic Valve Stenosis on Effect of Intensive Lipid Lowering Therapy (from the SEAS Study)

(2010) Eva Gerdts et al.   AMERICAN JOURNAL OF CARDIOLOGY

Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces

(2010) Ramaswamy Krishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The regulation of traction force in relation to cell shape and focal adhesions

(2010) Andrew D. Rape et al.   BIOMATERIALS

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis

(2010) Kwan Leung Chan et al.   CIRCULATION

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statins Block Calcific Nodule Formation of Valvular Interstitial Cells by Inhibiting α-Smooth Muscle Actin Expression

(2009) Julie A. Benton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Evolving Concepts of Cardiac Valve Dynamics

(2008) Frederick J. Schoen   CIRCULATION

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

(2008) Karien J. Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis

(2008) Anne B. Rossebø et al.   NEW ENGLAND JOURNAL OF MEDICINE