Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine

(2011) Wen Li Kelly Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL–Induced Mineralization of Human Vascular Smooth Muscle Cells

(2011) Jianyun Yan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The aortic valve microenvironment and its role in calcific aortic valve disease

(2011) Cindy Ying Yin Yip et al.   CARDIOVASCULAR PATHOLOGY

Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2

(2011) Yaoyao Du et al.   CIRCULATION RESEARCH

Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region

(2010) Elizabeth H. Stephens et al.   Acta Biomaterialia

Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration

(2010) Ruogang Zhao et al.   Acta Biomaterialia

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

(2010) Habib Derbali et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation

(2010) Xiaoxiao Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Evidence for Active Regulation of Pro-Osteogenic Signaling in Advanced Aortic Valve Disease

(2010) Jordan D. Miller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitral Valve Endothelial Cells With Osteogenic Differentiation Potential

(2010) Jill Wylie-Sears et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

(2010) Jan-Hung Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statin treatment of hypercholesterolemic-induced aortic valve sclerosis

(2010) Amanda M. Hamilton et al.   CARDIOVASCULAR PATHOLOGY

Correlates and Causes of Death in Patients With Severe Symptomatic Aortic Stenosis Who Are Not Eligible to Participate in a Clinical Trial of Transcatheter Aortic Valve Implantation

(2010) I. Ben-Dor et al.   CIRCULATION

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

(2010) Nadja Jastrebova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional structure–function relationships in mouse aortic valve tissue

(2010) Varun K. Krishnamurthy et al.   JOURNAL OF BIOMECHANICS

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents

(2010) Daihiko Hakuno et al.   JOURNAL OF CLINICAL INVESTIGATION

Networked-based Characterization of Extracellular Matrix Proteins from Adult Mouse Pulmonary and Aortic Valves

(2010) Peggi M. Angel et al.   JOURNAL OF PROTEOME RESEARCH

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Opposite Effects of Transforming Growth Factor-β1 and Vascular Endothelial Growth Factor on the Degeneration of Aortic Valvular Interstitial Cell Are Modified by the Extracellular Matrix Protein Fibronectin: Implications for Heart Valve Engineering

(2010) Patricia Gwanmesia et al.   TISSUE ENGINEERING PART A

Discoidin Domain Receptor-1 Deficiency Attenuates Atherosclerotic Calcification and Smooth Muscle Cell-Mediated Mineralization

(2009) Pamela J. Ahmad et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential

(2009) Jan-Hung Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

(2009) Kartik Balachandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of the MAPK/ERK pathway in valvular interstitial cell calcification

(2009) Xiaoxiao Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypercholesterolemia Induces Side-Specific Phenotypic Changes and Peroxisome Proliferator–Activated Receptor-γ Pathway Activation in Swine Aortic Valve Endothelium

(2009) Marie A. Guerraty et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Compositional Analysis of Heparin/Heparan Sulfate Interacting with Fibroblast Growth Factor·Fibroblast Growth Factor Receptor Complexes

(2009) Fuming Zhang et al.   BIOCHEMISTRY

The regulation of tenascin expression by tissue microenvironments

(2009) Richard P. Tucker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells

(2009) Kathryn E. Smith et al.   Biomechanics and Modeling in Mechanobiology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow

(2009) Cornelia Hahn et al.   CIRCULATION RESEARCH

Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries

(2009) Mei Y. Speer et al.   CIRCULATION RESEARCH

Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA/MONICA survey

(2009) J. Stritzke et al.   EUROPEAN HEART JOURNAL

On the biomechanics of heart valve function

(2009) Michael S. Sacks et al.   JOURNAL OF BIOMECHANICS

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease

(2009) Tatiana V. Tkatchenko et al.   PHYSIOLOGICAL GENOMICS

Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

(2009) Khalid S. Mohammad et al.   PLoS One

Collagens in the progression and complications of atherosclerosis

(2009) Eser Adiguzel et al.   VASCULAR MEDICINE

Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve

(2008) Elizabeth H. Stephens et al.   Acta Biomaterialia

Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves

(2008) M. Pho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficacy of Simvastatin Treatment of Valvular Interstitial Cells Varies With the Extracellular Environment

(2008) Elyssa L. Monzack et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evolving Concepts of Cardiac Valve Dynamics

(2008) Frederick J. Schoen   CIRCULATION

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

(2008) Paige Snider et al.   CIRCULATION RESEARCH

Periostin regulates atrioventricular valve maturation

(2008) Russell A. Norris et al.   DEVELOPMENTAL BIOLOGY

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

(2008) Melinda C. Cushing et al.   FASEB JOURNAL

Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation

(2008) Virva Pohjolainen et al.   HUMAN PATHOLOGY

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

(2008) Karien J. Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

(2008) Jordan D. Miller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcific Aortic Stenosis — Time to Look More Closely at the Valve

(2008) Catherine M. Otto   NEW ENGLAND JOURNAL OF MEDICINE

Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification

(2007) Marcel Liberman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY