Emerging Role of C5 Complement Pathway in Peripheral Neuropathies: Current Treatments and Future Perspectives

The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria

(2020) Alexander Röth et al.   BLOOD

Therapeutic Targeting of Vasculature in the Premetastatic and Metastatic Niches Reduces Lung Metastasis

(2020) Shanawaz M. Ghouse et al.   JOURNAL OF IMMUNOLOGY

The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment.

(2020) Eric Rondeau et al.   KIDNEY INTERNATIONAL

Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis

(2020) James F. Howard et al.   JAMA Neurology

Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice

(2020) Vinod Kumar et al.   ACS Omega

Chemotherapy-induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin-induced neurotoxicity

(2020) Kinga Sałat   Pharmacological Reports

Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

(2020) Kinga Sałat   Pharmacological Reports

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5

(2020) Adrianna Latuszek et al.   PLoS One

Components of the Lectin Pathway of Complement in Haematologic Malignancies

(2020) Maciej Cedzyński et al.   Cancers

Eculizumab impairs Neisseria meningitidis serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients

(2020) Jeroen D. Langereis et al.   Blood Advances

Non-Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review

(2020) Andreas Liampas et al.   ADVANCES IN THERAPY

Complement in neurological disorders and emerging complement-targeted therapeutics

(2020) Marinos C. Dalakas et al.   Nature Reviews Neurology

C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration

(2020) Glenn J. Jaffe et al.   OPHTHALMOLOGY

Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

(2020) Andra C. Dumitru et al.   Communications Biology

Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases

(2019) Dani AC Heesterbeek et al.   EMBO JOURNAL

Use of Eculizumab for Active Antibody-Mediated Rejection that Occurs Early Post-Kidney Transplantation

(2019) Ek Khoon Tan et al.   TRANSPLANTATION

The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury

(2019) Laura Brandolini et al.   NEUROTOXICITY RESEARCH

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

(2019) Sean J. Pittock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quality of Life in Painful Peripheral Neuropathies: A Systematic Review

(2019) Ayesha Girach et al.   Pain Research & Management

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

(2019) Jamileh A. Nabizadeh et al.   FASEB JOURNAL

Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain

(2019) Laura Brandolini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity

(2019) Xaria X. Li et al.   JOURNAL OF IMMUNOLOGY

Successful treatment of a PNH patient non‐responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)

(2019) Saskia Schols et al.   BRITISH JOURNAL OF HAEMATOLOGY

Eculizumab: A Review in Generalized Myasthenia Gravis

(2018) Sohita Dhillon   DRUGS

Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy

(2018) Jijun Xu et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial

(2018) Sonoko Misawa et al.   LANCET NEUROLOGY

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Models of the complement C1 complex

(2018) Simon A. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival

(2018) Ines Llaudo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Developments in anti-complement therapy; from disease to clinical trial

(2018) Claire L. Harris et al.   MOLECULAR IMMUNOLOGY

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

(2018) Seline A. Zwarthoff et al.   Frontiers in Immunology

Analysis of the TTR gene in the investigation of amyloidosis: A 25-year single UK center experience

(2018) Dorota Rowczenio et al.   HUMAN MUTATION

Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy

(2017) Justin G. Lees et al.   EUROPEAN JOURNAL OF CANCER

The complement system in cancer: Ambivalence between tumour destruction and promotion

(2017) Srinivas Mamidi et al.   IMMUNOBIOLOGY

The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells

(2017) Anna V. Wiese et al.   PLoS One

Expanding horizons in complement drug discovery: challenges and emerging strategies

(2017) Claire L. Harris   Seminars in Immunopathology

The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

(2017) Ting Zhang et al.   Journal of Immunology Research

High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine

(2017) Lucy A. McNamara et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

An Update on the Use of Immunomodulators in Primary Immunodeficiencies

(2016) Pandiarajan Vignesh et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment

(2016) Anil K. Jasti et al.   Expert Review of Clinical Immunology

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

(2016) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway

(2016) Janus Asbjørn Schatz-Jakobsen et al.   JOURNAL OF IMMUNOLOGY

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

(2016) Leonid P. Shutov et al.   JOURNAL OF NEUROSCIENCE

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

(2016) Zhuo A. Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

C5a and pain development: An old molecule, a new target

(2016) Andreza U. Quadros et al.   PHARMACOLOGICAL RESEARCH

Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation

(2016) T. R. Kjaer et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

(2016) Vernon Seow et al.   Scientific Reports

The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of Falling

(2016) Noah A. Kolb et al.   JAMA Neurology

Terminal complement activation is increased and associated with disease severity in CIDP

(2016) Isaak Quast et al.   Annals of Clinical and Translational Neurology

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

(2016) Rhona McGonigal et al.   Acta Neuropathologica Communications

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype

(2015) Emily K Mathey et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway

(2014) Minoru Takahashi et al.   JOURNAL OF IMMUNOLOGY

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

(2014) Alessio Moriconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria

(2013) C. Fokke et al.   BRAIN

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Axonal Guillain-Barré syndrome: concepts and controversies

(2013) Satoshi Kuwabara et al.   LANCET NEUROLOGY

Guideline of transthyretin-related hereditary amyloidosis for clinicians

(2013) Yukio Ando et al.   Orphanet Journal of Rare Diseases

Complement Component C1q Regulates Macrophage Expression of Mer Tyrosine Kinase To Promote Clearance of Apoptotic Cells

(2012) M. D. Galvan et al.   JOURNAL OF IMMUNOLOGY

Liver transplantation and transthyretin amyloidosis

(2012) Merrill D. Benson   MUSCLE & NERVE

Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence

(2011) David Balayssac et al.   Expert Opinion On Drug Safety

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

(2011) Maria I Fonseca et al.   Journal of Neuroinflammation

Increased local concentration of complement C5a contributes to incisional pain in mice

(2011) Jun H Jang et al.   Journal of Neuroinflammation

Familial amyloid polyneuropathy

(2011) Violaine Planté-Bordeneuve et al.   LANCET NEUROLOGY

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

Advances in the diagnosis, pathogenesis and treatment of CIDP

(2011) Marinos C. Dalakas   Nature Reviews Neurology

The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model

(2011) De-Yong Liang et al.   PAIN

Pain and death: Neurodegenerative disease mechanisms in the nociceptor

(2010) David B. Reichling et al.   ANNALS OF NEUROLOGY

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Complement component 5a (C5a)

(2009) Helga D. Manthey et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nociceptive sensitization by complement C5a and C3a in mouse

(2009) Jun Ho Jang et al.   PAIN

Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model

(2008) Susan K. Halstead et al.   BRAIN

Epidemiology of familial amyloid polyneuropathy in Japan: Identification of a novel endemic focus

(2008) Yuko Kato-Motozaki et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The complement system in the peripheral nerve: Friend or foe?

(2008) V. Ramaglia et al.   MOLECULAR IMMUNOLOGY

Structure of and influence of a tick complement inhibitor on human complement component 5

(2008) Folmer Fredslund et al.   NATURE IMMUNOLOGY

The Epidemiology of Guillain-Barré Syndrome Worldwide

(2008) Anita McGrogan et al.   NEUROEPIDEMIOLOGY

FDA Report: Eculizumab (Soliris(R)) for the Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria

(2008) A. Dmytrijuk et al.   ONCOLOGIST

Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

(2007) E Ting et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells

(2007) Hai Wei Jin et al.   EXPERIMENTAL NEUROLOGY