Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
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Title
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
Authors
Keywords
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Journal
Communications Biology
Volume 3, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-12-18
DOI
10.1038/s42003-020-01518-8
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- (2008) Abhiram Dukkipati et al. PROTEIN EXPRESSION AND PURIFICATION
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