Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation
Published 2021 View Full Article
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Title
Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation
Authors
Keywords
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Journal
CRISPR Journal
Volume 4, Issue 2, Pages 169-177
Publisher
Mary Ann Liebert Inc
Online
2021-04-20
DOI
10.1089/crispr.2020.0144
References
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Related references
Note: Only part of the references are listed.- Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
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- (2020) Shannon M. Miller et al. NATURE BIOTECHNOLOGY
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- (2020) Gaetan Burgio GENE THERAPY
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- (2020) Michelle F. Richter et al. NATURE BIOTECHNOLOGY
- Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
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- Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing
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- (2020) Yajing Liu et al. Nature Communications
- Engineering of high-precision base editors for site-specific single nucleotide replacement
- (2019) Junjie Tan et al. Nature Communications
- Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
- (2019) Erwei Zuo et al. SCIENCE
- Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice
- (2019) Shuai Jin et al. SCIENCE
- Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
- (2019) Julian Grünewald et al. NATURE
- Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
- (2019) Tony P. Huang et al. NATURE BIOTECHNOLOGY
- Analysis and minimization of cellular RNA editing by DNA adenine base editors
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- An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
- (2018) Jason M Gehrke et al. NATURE BIOTECHNOLOGY
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- (2017) Nicole M. Gaudelli et al. NATURE
- Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
- (2017) Y Bill Kim et al. NATURE BIOTECHNOLOGY
- Sickle Cell Disease
- (2017) Frédéric B. Piel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
- (2016) F. Jiang et al. SCIENCE
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- Steric and hydrophobic determinants of the solubilities of recombinant sickle cell hemoglobins
- (2010) M.T. Bihoreau et al. PROTEIN SCIENCE
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