Directed evolution of adenine base editors with increased activity and therapeutic application
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Title
Directed evolution of adenine base editors with increased activity and therapeutic application
Authors
Keywords
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Journal
NATURE BIOTECHNOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-04-14
DOI
10.1038/s41587-020-0491-6
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- Analysis and minimization of cellular RNA editing by DNA adenine base editors
- (2019) Holly A. Rees et al. Science Advances
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- (2019) Julian Grünewald et al. NATURE BIOTECHNOLOGY
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- (2019) Erica McGrath et al. Nature Communications
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- (2019) Beau R. Webber et al. Nature Communications
- Highly Efficient A·T to G·C Base Editing by Cas9n-Guided tRNA Adenosine Deaminase in Rice
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- (2018) Yanting Zeng et al. MOLECULAR THERAPY
- Expanding the base editing scope in rice by using Cas9 variants
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- (2016) Jiangtao Ren et al. CLINICAL CANCER RESEARCH
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- Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
- (2015) Laurent Poirot et al. CANCER RESEARCH
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- (2015) F. Ann Ran et al. NATURE
- Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
- (2015) Ayal Hendel et al. NATURE BIOTECHNOLOGY
- ClinVar: public archive of interpretations of clinically relevant variants
- (2015) Melissa J. Landrum et al. NUCLEIC ACIDS RESEARCH
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- ClinVar: public archive of relationships among sequence variation and human phenotype
- (2013) Melissa J. Landrum et al. NUCLEIC ACIDS RESEARCH
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- (2012) M. Jinek et al. SCIENCE
- Miscoding Properties of 2′-Deoxyinosine, a Nitric Oxide-Derived DNA Adduct, during Translesion Synthesis Catalyzed by Human DNA Polymerases
- (2008) Manabu Yasui et al. JOURNAL OF MOLECULAR BIOLOGY
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