Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole–Indole Hybrids

Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates

(2020) Mohamed H. Abo-Ghalia et al.   MOLECULES

Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability

(2019) Burri Nagaraju et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents

(2019) Sraa Abu-Melha et al.   MOLECULES

Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids

(2019) Hong Dai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

V2O5/SiO2 as an efficient catalyst in the synthesis of 5-amino- pyrazole derivatives under solvent free condition

(2019) T. K. Khatab et al.   BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA

Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase

(2019) Hany S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers

(2019) Ahmed M. Sh. El-Sharief et al.   BIOORGANIC CHEMISTRY

Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents

(2019) Mogedda E. Haiba et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

(2019) Ahmed A Elhenawy et al.   Drug Design Development and Therapy

Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives

(2019) Asmaa F. Kassem et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Design, Synthesis of Novel Cyclic Pentapeptide Derivatives Based on 1,2-Benzenedicarbonyl Chloride with Expected Anticancer Activity

(2019) Gaber O Moustafa et al.   Journal of Computational and Theoretical Nanoscience

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles

(2019) Ashraf Hassan et al.   MOLECULES

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides

(2019) Alminderej et al.   MOLECULES

Targeting CDK2 in cancer: challenges and opportunities for therapy

(2019) Solomon Tadesse et al.   DRUG DISCOVERY TODAY

Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines

(2018) Mohamed El-Naggar et al.   MOLECULES

Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation

(2018) Shivani Jaiswal et al.   BIOMEDICINE & PHARMACOTHERAPY

Analysis of DNA protection, interaction and antimicrobial activity of isatin derivatives

(2018) Mohamed Abdulhamid Ganim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor

(2018) Asmaa A. Magd-El-Din et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Fluoroquinolone-isatin hybrids and their biological activities

(2018) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Characterization, and In Vitro Evaluation of Isatin‐Pomalidomide Hybrids for Cytotoxicity against Multiple Myeloma Cell Lines

(2018) Shyam Panga et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and antibacterial evaluation of fused pyrazoles and Schiff bases

(2018) Ashraf S. Hassan et al.   SYNTHETIC COMMUNICATIONS

Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies

(2018) Faryal Chaudhry et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents

(2017) Ashraf S. Hassan et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity

(2017) B. Madhavilatha et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and in vitro anticancer activity of pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-d][1,2,3]triazines

(2017) Ashraf S. Hassan et al.   SYNTHETIC COMMUNICATIONS

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

(2017) Katarina Bačević et al.   Scientific Reports

Design, Synthesis andIn VitroAntiproliferative Activity of Novel Isatin-Quinazoline Hybrids

(2015) Mohamed Fares et al.   ARCHIV DER PHARMAZIE

Discovery of novel isatin–dehydroepiandrosterone conjugates as potential anticancer agents

(2015) Shaoyong Ke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: Design, synthesis, QSAR analysis and anticancer activity

(2015) Ahmed M. Alafeefy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents

(2015) Mohamed F. Mady et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-$a$]pyrimidines and related Schiff bases

(2015) Ashraf Sayed HASSAN et al.   TURKISH JOURNAL OF CHEMISTRY

Ultrasound-assisted synthesis of novel 1,2,3-triazoles coupled diaryl sulfone moieties by the CuAAC reaction, and biological evaluation of them as antioxidant and antimicrobial agents

(2014) Mohamed F. Mady et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3

(2013) Weijie Gao et al.   APOPTOSIS

Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes

(2013) Souad Osman et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Design of New Drug Molecules to be Used in Reversing Multidrug Resistance in Cancer Cells

(2009) Y. Mayur et al.   CURRENT CANCER DRUG TARGETS

Design and Synthesis of the First Thiophene Thioglycosides

(2009) Galal H. Elgemeie et al.   SYNTHETIC COMMUNICATIONS

Simple and Efficient Microwave Assisted N-Alkylation of Isatin

(2008) María Shmidt et al.   MOLECULES

Direct Route to a New Class of Acrylamide Thioglycosides and Their Conversions to Pyrazole Derivatives

(2008) Galal H. Elgemeie et al.   SYNTHETIC COMMUNICATIONS