Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis

Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice

(2021) Enchen Zhou et al.   PHARMACOLOGICAL RESEARCH

High Brown Fat Activity Correlates With Cardiovascular Risk Factor Levels Cross-Sectionally and Subclinical Atherosclerosis at 5-Year Follow-Up

(2020) Juho Raiko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Exercise and browning of white adipose tissue – a translational perspective

(2020) Mai Charlotte Krogh Severinsen et al.   CURRENT OPINION IN PHARMACOLOGY

Fibroblast Growth Factor 21 and Browning of White Adipose Tissue

(2019) Daniel Cuevas-Ramos et al.   Frontiers in Physiology

Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression

(2019) Anna Worthmann et al.   Nutrients

Adipokines: Linking metabolic syndrome, the immune system, and arthritic diseases

(2019) Vera Francisco et al.   BIOCHEMICAL PHARMACOLOGY

Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis

(2019) Wenhai Sui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice

(2019) Greg L. McKie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Contribution of brown adipose tissue to human energy metabolism

(2019) Rodrigo Fernández-Verdejo et al.   MOLECULAR ASPECTS OF MEDICINE

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

(2019) Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leptin, cardiovascular diseases and type 2 diabetes mellitus

(2018) Niki Katsiki et al.   ACTA PHARMACOLOGICA SINICA

Effects of exercise on brown and beige adipocytes

(2018) Revati S. Dewal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Comparative studies on the effects of high-fat diet, endurance training and obesity on Ucp1 expression in male C57BL/6 mice

(2018) Samaneh Shirkhani et al.   GENE

Brown and beige adipose tissues: phenotype and metabolic potential in mice and men

(2018) Kanta Chechi et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Common and Distinct Features of Brown and Beige Adipocytes

(2018) Kenji Ikeda et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice

(2018) Sebastien M Labbe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy

(2018) Winifred W. Yau et al.   Autophagy

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation

(2018) Patricia Vázquez et al.   JOURNAL OF LIPID RESEARCH

Targeting white, brown and perivascular adipose tissue in atherosclerosis development

(2017) Andrea D. van Dam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

(2017) Yuta Hiraike et al.   NATURE CELL BIOLOGY

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

(2017) Anna Worthmann et al.   NATURE MEDICINE

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

(2016) Vanessa Pellegrinelli et al.   DIABETOLOGIA

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

(2016) Dimitris Tousoulis et al.   EUROPEAN HEART JOURNAL

Supraclavicular Brown Adipose Tissue 18F-FDG Uptake and Cardiovascular Disease

(2016) R. A. P. Takx et al.   JOURNAL OF NUCLEAR MEDICINE

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

(2016) Juliane Weiner et al.   Scientific Reports

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis

(2015) Kristin I. Stanford et al.   DIABETES

Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes

(2015) Denis P. Blondin et al.   DIABETES

Adipokines at the crossroad between obesity and cardiovascular disease

(2015) Sandrine Morel et al.   THROMBOSIS AND HAEMOSTASIS

The brown fat secretome: metabolic functions beyond thermogenesis

(2015) Guo-Xiao Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Serum FGF21 levels are associated with brown adipose tissue activity in humans

(2015) Mark J.W. Hanssen et al.   Scientific Reports

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6

(2015) Chong Yew Tan et al.   Cell Reports

The Therapeutic Potential of Brown Adipocytes in Humans

(2015) Craig Porter et al.   Frontiers in Endocrinology

Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells

(2015) Jun Hong Park et al.   Frontiers in Endocrinology

Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human

(2015) Qidi Wang et al.   PLoS One

Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis

(2014) Nikolaos Alexopoulos et al.   ATHEROSCLEROSIS

Inflammation and Atherosclerosis

(2014) Joshua Hartman et al.   Cardiology in Review

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Inflammation and macrophage modulation in adipose tissues

(2014) Victoria J. Vieira-Potter   CELLULAR MICROBIOLOGY

Negative Regulators of Brown Adipose Tissue (BAT)-Mediated Thermogenesis

(2014) Bal Krishan Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men

(2014) Denis P. Blondin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of IL-6 in Exercise Training- and Cold-Induced UCP1 Expression in Subcutaneous White Adipose Tissue

(2014) Jakob G. Knudsen et al.   PLoS One

Should visceral fat be reduced to increase longevity?

(2013) Carmine Finelli et al.   AGEING RESEARCH REVIEWS

State of the art paper Biochemistry of adipose tissue: an endocrine organ

(2013) Marisa Coelho et al.   Archives of Medical Science

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo

(2013) Peter F. Davies et al.   CARDIOVASCULAR RESEARCH

Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

(2013) Mei Dong et al.   Cell Metabolism

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Stabilization of atherosclerotic plaques: an update

(2013) S. Yla-Herttuala et al.   EUROPEAN HEART JOURNAL

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity

(2012) Julien Auffret et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease

(2012) Kanta Chechi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of adipokines in cardiovascular disease

(2012) Harman S Mattu et al.   JOURNAL OF ENDOCRINOLOGY

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension

(2011) V.A. Braga et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

(2011) Lei Cao et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis

(2011) Hosam Hasan-Ali et al.   CORONARY ARTERY DISEASE

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

The evolution of the adipose tissue: A neglected enigma

(2011) Enzo Ottaviani et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Adipokines and blood pressure control

(2010) Frederique Yiannikouris et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

Propagation of adipogenic signals through an epigenomic transition state

(2010) D. J. Steger et al.   GENES & DEVELOPMENT

The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease

(2010) D. Margriet Ouwens et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway

(2010) Wei-Yen Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

(2010) Takeshi Yoneshiro et al.   Obesity

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Plasma apelin concentration is depressed following acute myocardial infarction in man

(2009) Robin A.P. Weir et al.   EUROPEAN JOURNAL OF HEART FAILURE

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE