The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight

(2019) Giacomo Mancini et al.   Cell Reports

Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge

(2018) Yuan Lu et al.   Scientific Reports

Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

(2018) Tanila Wood dos Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms

(2017) Edward T. Chouchani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats

(2016) Haiyan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

UCPs, at the interface between bioenergetics and metabolism

(2016) Frédéric Bouillaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle

(2016) Giorgos K. Sakellariou et al.   FASEB JOURNAL

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

(2016) Antigoni Lalia et al.   Nutrients

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

(2016) Euy‐Myoung Jeong et al.   Journal of the American Heart Association

Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes

(2015) Britta Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

(2015) Sini Heinonen et al.   DIABETES

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics

(2015) Maria Fernanda Forni et al.   STEM CELLS

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

(2014) Jakob D Wikstrom et al.   EMBO JOURNAL

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

(2014) João Marcus Oliveira Andrade et al.   EUROPEAN JOURNAL OF NUTRITION

Mitochondrial function/dysfunction in white adipose tissue

(2014) Sihem Boudina et al.   EXPERIMENTAL PHYSIOLOGY

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol

(2014) Christine Feillet-Coudray et al.   FREE RADICAL RESEARCH

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

(2014) Anna Park   World Journal of Stem Cells

Transcriptional fingerprinting of “browning” white fat identifies NRG4 as a novel adipokine

(2014) Mark Christian   Adipocyte

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Mitochondrial dysfunction and complications associated with diabetes

(2013) Rachel Blake et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

(2013) Michaela Keuper et al.   FASEB JOURNAL

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Brown Adipose Tissue: Research Milestones of a Potential Player in Human Energy Balance and Obesity

(2013) B. Zafrir   HORMONE AND METABOLIC RESEARCH

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells

(2013) Yanmin Zhang et al.   PLoS One

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

(2013) Min Jeong Ryu et al.   PLoS Genetics

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Dysfunction and Lipid Homeostasis

(2012) Joseph Vamecq et al.   CURRENT DRUG METABOLISM

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

(2012) Chih-Hao Wang et al.   FEBS Journal

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Exercise as a new physiological stimulus for brown adipose tissue activity

(2012) R. De Matteis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

Calorie restriction and prevention of age-associated chronic disease

(2011) Daniela Omodei et al.   FEBS LETTERS

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus

(2011) Mrittika Chattopadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

(2011) Rosario Pardo et al.   PLoS One

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Mitochondrial dysfunction in obesity

(2011) Juan C Bournat et al.   Current Opinion in Endocrinology Diabetes and Obesity

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes

(2011) James X. Rong et al.   PPAR Research

Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes

(2010) Chih-Hao Wang et al.   Annals of the New York Academy of Sciences

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis

(2010) E. Yehuda-Shnaidman et al.   DIABETES

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity

(2010) Regitze Kraunsøe et al.   JOURNAL OF PHYSIOLOGY-LONDON

TNF-α induces mitochondrial dysfunction in 3T3-L1 adipocytes

(2010) Xiao-Hui Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes

(2010) Chun-Lin Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

(2009) Aurélia De Pauw et al.   AMERICAN JOURNAL OF PATHOLOGY

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions

(2009) Francesca Forner et al.   Cell Metabolism

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components

(2009) Jaap Keijer et al.   CURRENT OPINION IN LIPIDOLOGY

The role of mitochondria in health and disease

(2009) Darcy L Johannsen et al.   CURRENT OPINION IN PHARMACOLOGY

Possible Role of Mitochondrial Remodelling on Cellular Triacylglycerol Accumulation

(2009) T. Kita et al.   JOURNAL OF BIOCHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates adipose mass and differentiation in mice

(2009) Rajat Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

The Origins of Brown Adipose Tissue

(2009) Sven Enerbäck   NEW ENGLAND JOURNAL OF MEDICINE

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance

(2008) Lindsey N. Sutherland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE