CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress

Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

(2021) Iryna Kamienieva et al.   Translational Neurodegeneration

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation

(2020) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway

(2020) Jialiang Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF ‐1α– BNIP3 Axis

(2020) Vedavathi Madhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Compression‐induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway

(2020) Donghua Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitophagy in degenerative joint diseases

(2020) Kai Sun et al.   Autophagy

Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy

(2020) Na Zhao et al.   Journal of Sport and Health Science

New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs

(2020) Tao Lan et al.   AGEING RESEARCH REVIEWS

Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells

(2020) Qian Xiang et al.   Oxidative Medicine and Cellular Longevity

6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy

(2020) Li-Ping Nan et al.   World Journal of Stem Cells

Multiplex Epigenome Editing of DRG Neuron Receptors Abolishes Redundant IL-6, TNF-α, and IL-1β Signaling by the Degenerative IVD

(2019) Joshua Stover et al.   HUMAN GENE THERAPY

lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells

(2019) Shengfeng Zhan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects

(2019) Chen Xia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses

(2019) Liang Kang et al.   LIFE SCIENCES

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy

(2018) Yiyang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevention and treatment of low back pain: evidence, challenges, and promising directions

(2018) Nadine E Foster et al.   LANCET

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes

(2018) M.Y. Ansari et al.   OSTEOARTHRITIS AND CARTILAGE

Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

(2018) Wei Guo et al.   Cell Death & Disease

LncRNA HOTAIR suppresses TNF-α induced apoptosis of nucleus pulposus cells by regulating miR-34a/Bcl-2 axis

(2018) Yang Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

(2017) Chencheng Feng et al.   Oxidative Medicine and Cellular Longevity

Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway

(2017) Sheng Chen et al.   Stem Cells International

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

(2014) Tiffany Kadow et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells

(2013) Eun-Young Park et al.   INTERNATIONAL ORTHOPAEDICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

MiR-27a Regulates Apoptosis in Nucleus Pulposus Cells by Targeting PI3K

(2013) Gang Liu et al.   PLoS One

Autophagy receptors in developmental clearance of mitochondria

(2011) Ivana Novak et al.   Autophagy

The Epidemiology of low back pain

(2011) D. Hoy et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY