Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?

CREB: A Multifaceted Target for Alzheimer’s Disease

(2021) Vivek K. Sharma et al.   Current Alzheimer Research

Stressed mitochondria: A target to intrude alzheimer’s disease

(2021) Vivek Kumar Sharma et al.   MITOCHONDRION

Born to Protect: Leveraging BDNF Against Cognitive Deficit in Alzheimer’s Disease

(2020) Lucia Caffino et al.   CNS DRUGS

Alzheimer’s Disorder: Epigenetic connection and associated risk factors

(2020) Vivek Kumar Sharma et al.   Current Neuropharmacology

Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

(2020) Shareen Singh et al.   Current Neuropharmacology

Effect of N‐palmitoylethanolamine‐oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel disease

(2020) Marika Cordaro et al.   FASEB JOURNAL

Microglia, Lifestyle Stress, and Neurodegeneration

(2020) Charlotte Madore et al.   IMMUNITY

Ketogenic Diet for the Treatment and Prevention of Dementia: A Review

(2020) Joshua J. Davis et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Adolescence and Aging: Impact of Adolescence Inflammatory Stress and Microbiota Alterations on Brain Development, Aging, and Neurodegeneration

(2020) Nour Yahfoufi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Toward Understanding Microbiome-Neuronal Signaling

(2020) K.G. Jameson et al.   MOLECULAR CELL

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

(2020) Sholpan Askarova et al.   Frontiers in Cellular and Infection Microbiology

Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease

(2020) Veerta Sharma et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

(2020) Shan Liu et al.   MOLECULAR NEUROBIOLOGY

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease

(2020) Feiqi Zhu et al.   Frontiers in Aging Neuroscience

The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats

(2020) Hanaa R. Aboelwafa et al.   Brain Sciences

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

(2020) Nicole Jacqueline Jensen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease

(2020) Vivek Kumar Sharma et al.   LIFE SCIENCES

The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?

(2020) Ashwinipriyadarshini Megur et al.   Nutrients

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

(2019) Marie Lindefeldt et al.   npj Biofilms and Microbiomes

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

(2019) Michela Bistoletti et al.   PLoS One

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

Gut Microbiota in Alzheimer’s Disease, Depression, and Type 2 Diabetes Mellitus: The Role of Oxidative Stress

(2019) Maria Luca et al.   Oxidative Medicine and Cellular Longevity

A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster

(2019) Susan Westfall et al.   PLoS One

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms

(2019) Huajun Yang et al.   Frontiers in Neurology

Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice

(2019) Xueqin Yang et al.   Acta Pharmaceutica Sinica B

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

(2019) Min-Soo Kim et al.   GUT

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

(2019) Jing Sun et al.   Translational Psychiatry

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

(2019) Ravinder Nagpal et al.   EBioMedicine

Navigating Alzheimer’s Disease via Chronic Stress: the Role of Glucucocorticoids

(2019) Vivek Kumar Sharma et al.   CURRENT DRUG TARGETS

Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease

(2019) Dong-oh Seo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Gut microbiome diversity is associated with sleep physiology in humans

(2019) Robert P. Smith et al.   PLoS One

Keto microbiota: A powerful contributor to host disease recovery

(2019) Amanda Cabrera-Mulero et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Neuroinflammation and the Gut Microbiota: Possible Alternative Therapeutic Targets to Counteract Alzheimer’s Disease?

(2019) Milica Cerovic et al.   Frontiers in Aging Neuroscience

Interactions Between Gut Microbiota and Acute Restraint Stress in Peripheral Structures of the Hypothalamic–Pituitary–Adrenal Axis and the Intestine of Male Mice

(2019) Karla Vagnerová et al.   Frontiers in Immunology

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

(2019) Antonella Amato et al.   Antioxidants

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

(2019) Harrisham Kaur et al.   Frontiers in Neuroscience

The microbiome-gut-brain axis in acute and chronic brain diseases

(2019) Corinne Benakis et al.   CURRENT OPINION IN NEUROBIOLOGY

Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats

(2018) Somayeh Athari Nik Azm et al.   Applied Physiology Nutrition and Metabolism

Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor-β1

(2018) Yanan Li et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Impact of gut microbiota on neurological diseases: Diet composition and novel treatments

(2018) Ana Larroya-García et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats

(2018) Tao Wu et al.   LIFE SCIENCES

Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems

(2018) R. J. Mulders et al.   Obesity Reviews

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

(2018) Ye Ding et al.   Immunity & Ageing

Helicobacter pylori Filtrate Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Glycogen Synthase Kinase-3β

(2018) Xiu-Lian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

(2018) Vanessa de J.R. De-Paula et al.   PHARMACOLOGICAL RESEARCH

The gut microbiome as a driver of individual variation in cognition and functional behaviour

(2018) Gabrielle L. Davidson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immobilization stress-induced Escherichia coli causes anxiety by inducing NF-κB activation through gut microbiota disturbance

(2018) Hyo-Min Jang et al.   Scientific Reports

Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota

(2018) J. Philip Karl et al.   Frontiers in Microbiology

Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease

(2018) Vo Giau et al.   Nutrients

The Role of the Intestinal Microbiome in Chronic Psychosocial Stress-Induced Pathologies in Male Mice

(2018) Dominik Langgartner et al.   Frontiers in Behavioral Neuroscience

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

(2017) Joseph M. Pickard et al.   IMMUNOLOGICAL REVIEWS

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease

(2017) Abigail Mariga et al.   NEUROBIOLOGY OF DISEASE

The role of microbial amyloid in neurodegeneration

(2017) Robert P. Friedland et al.   PLoS Pathogens

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease

(2016) Cristiano Köhler et al.   CURRENT PHARMACEUTICAL DESIGN

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

(2016) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Probiotics, gut microbiota, and their influence on host health and disease

(2016) Borja Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

(2016) G B Rogers et al.   MOLECULAR PSYCHIATRY

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

(2016) Raeesah Maqsood et al.   NEUROCHEMICAL RESEARCH

Alzheimer’s disease and gut microbiota

(2016) Xu Hu et al.   Science China-Life Sciences

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

(2016) Elmira Akbari et al.   Frontiers in Aging Neuroscience

l-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder

(2015) Tao Wu et al.   GENE

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

The Microbiota and Microbiome in Aging: Potential Implications in Health and Age-Related Diseases

(2015) Heidi J. Zapata et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

(2015) S. Liang et al.   NEUROSCIENCE

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Inflammatory Bowel Disease as a Model for Translating the Microbiome

(2014) Curtis Huttenhower et al.   IMMUNITY

Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics

(2014) Theresa E. Cowan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2014) Elena Biagi et al.   PLoS One

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

(2014) Eleonora Distrutti et al.   PLoS One

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

The Gastrointestinal Tract Microbiome and Potential Link to Alzheimer’s Disease

(2014) James M. Hill et al.   Frontiers in Neurology

Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments

(2013) Gregory Oxenkrug   CURRENT DRUG TARGETS

Alzheimer´s Disease and Oxidative Stress: A Review

(2013) Miroslav Pohanka   CURRENT MEDICINAL CHEMISTRY

Microbial amyloids – functions and interactions within the host

(2013) Kelly Schwartz et al.   CURRENT OPINION IN MICROBIOLOGY

The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness

(2013) Mady Hornig   CURRENT OPINION IN RHEUMATOLOGY

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice

(2013) A. Ait-Belgnaoui et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gut Microbiota Composition in Male Rat Models under Different Nutritional Status and Physical Activity and Its Association with Serum Leptin and Ghrelin Levels

(2013) María Isabel Queipo-Ortuño et al.   PLoS One

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Alzheimer's disease and the microbiome

(2013) Surjyadipta Bhattacharjee et al.   Frontiers in Cellular Neuroscience

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I – autointoxication revisited

(2013) Alison C Bested et al.   Gut Pathogens

Disease to Dirt: The Biology of Microbial Amyloids

(2013) David A. Hufnagel et al.   PLoS Pathogens

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease

(2012) Ji-Jing Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

On communication between gut microbes and the brain

(2012) Paul Forsythe et al.   CURRENT OPINION IN GASTROENTEROLOGY

Metabolomics View on Gut Microbiome Modulation by Polyphenol-rich Foods

(2012) Sofia Moco et al.   JOURNAL OF PROTEOME RESEARCH

Genomic variation landscape of the human gut microbiome

(2012) Siegfried Schloissnig et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Gut microbiota and gastrointestinal health: current concepts and future directions

(2012) Q. Aziz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

(2012) Carissa M. Thomas et al.   PLoS One

MyD88 Deficiency Ameliorates β-Amyloidosis in an Animal Model of Alzheimer's Disease

(2011) Jeong-Eun Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

Stress- and Allostasis-Induced Brain Plasticity

(2010) Bruce S. McEwen et al.   Annual Review of Medicine

Mucosal T cells in gut homeostasis and inflammation

(2010) Femke van Wijk et al.   Expert Review of Clinical Immunology

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

(2009) D Mariat et al.   BMC MICROBIOLOGY

Nitric Oxide Production by the Human Intestinal Microbiota by Dissimilatory Nitrate Reduction to Ammonium

(2009) Joan Vermeiren et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine (H1) receptor activation-linked mechanism

(2009) Ashish K. Rehni et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease

(2009) Sarah M. Rothman et al.   NEUROMOLECULAR MEDICINE

Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease

(2009) R. Sims et al.   NEUROSCIENCE LETTERS

The Role of Microbiota and Probiotics in Stress-Induced Gastrointestinal Damage

(2008) Femke Lutgendorff et al.   CURRENT MOLECULAR MEDICINE

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genome-scale analyses of health-promoting bacteria: probiogenomics

(2008) Marco Ventura et al.   NATURE REVIEWS MICROBIOLOGY