The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

(2016) Esther E. Fröhlich et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid

(2016) Cheng-Fu Li et al.   BRAIN RESEARCH

Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk geneneuregulin 1

(2016) S. Holm-Hansen et al.   GENES BRAIN AND BEHAVIOR

Controversies Revisited

(2016) Antonina Mikocka-Walus et al.   INFLAMMATORY BOWEL DISEASES

Brief Report

(2016) P. Elliott Miller et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Altered interleukin-18 levels are associated with cognitive impairment in chronic schizophrenia

(2016) Jing Qin Wu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Administration of Non-Absorbable Antibiotics to Pregnant Mice to Perturb the Maternal Gut Microbiota Is Associated with Alterations in Offspring Behavior

(2016) Shiro Tochitani et al.   PLoS One

Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis

(2016) Pamela Farshim et al.   Scientific Reports

Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats

(2016) Heather A. Paul et al.   Scientific Reports

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

(2016) Maria Carmen Collado et al.   Scientific Reports

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

(2015) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Exopolysaccharides Produced by Lactic Acid Bacteria and Bifidobacteria as Fermentable Substrates by the Intestinal Microbiota

(2015) Nuria Salazar et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

AAV1/2-mediated BDNF gene therapy in a transgenic rat model of Huntington’s disease

(2015) B Connor et al.   GENE THERAPY

The use of ketamine as an antidepressant: a systematic review and meta-analysis

(2015) Caoimhe M. Coyle et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Childhood Maltreatment Is Associated with Ulcerative Colitis but Not Crohnʼs Disease

(2015) Esme Fuller-Thomson et al.   INFLAMMATORY BOWEL DISEASES

Lactation and Intestinal Microbiota: How Early Diet Shapes the Infant Gut

(2015) Felicia Goldsmith et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Behavioral and cognitive effects of the N-methyl-d-aspartate receptor co-agonist d-serine in healthy humans: Initial findings

(2015) Raz Levin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Collective unconscious: How gut microbes shape human behavior

(2015) Timothy G. Dinan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Lactobacillus pentosusvar.plantarumC29 ameliorates age-dependent memory impairment in Fischer 344 rats

(2015) J.-J. Jeong et al.   LETTERS IN APPLIED MICROBIOLOGY

Stimulation of synthesis and release of brain-derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase-activating peptide

(2015) M. Al-Qudah et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

(2015) S. Liang et al.   NEUROSCIENCE

Investigating the long-term effect of subchronic phencyclidine-treatment on novel object recognition and the association between the gut microbiota and behavior in the animal model of schizophrenia

(2015) B. Pyndt Jørgensen et al.   PHYSIOLOGY & BEHAVIOR

Schizophrenia and the gut–brain axis

(2015) Katlyn Nemani et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Increased interleukin-2 serum levels were associated with psychopathological symptoms and cognitive deficits in treatment-resistant schizophrenia

(2015) Yunlong Tan et al.   SCHIZOPHRENIA RESEARCH

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia

(2015) Samuel M. Cohen et al.   SCHIZOPHRENIA RESEARCH

BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A

(2015) David Lau et al.   Cell Reports

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

(2015) Bruno K Rodiño-Janeiro et al.   Journal of Neurogastroenterology and Motility

Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway

(2014) Mazura Pisar et al.   BRAIN RESEARCH

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Sodium Butyrate Functions as an Antidepressant and Improves Cognition with Enhanced Neurotrophic Expression in Models of Maternal Deprivation and Chronic Mild Stress

(2014) Samira Valvassori et al.   CURRENT NEUROVASCULAR RESEARCH

Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein

(2014) C L Frankenfeld et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Rapid-onset antidepressant action of ketamine: potential revolution in understanding and future pharmacologic treatment of depression

(2014) E. Drewniany et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Lactoferrin up-regulates intestinal gene expression of brain-derived neurotrophic factors BDNF, UCHL1 and alkaline phosphatase activity to alleviate early weaning diarrhea in postnatal piglets

(2014) Changwei Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Is a foetus developing in a sterile environment?

(2014) T.M. Wassenaar et al.   LETTERS IN APPLIED MICROBIOLOGY

Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation

(2014) Janis Kuka et al.   LIFE SCIENCES

The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling

(2014) Yingcong Yu et al.   METABOLIC BRAIN DISEASE

Genomics of schizophrenia: time to consider the gut microbiome?

(2014) T G Dinan et al.   MOLECULAR PSYCHIATRY

NMDA receptor dysregulation in chronic state: A possible mechanism underlying depression with BDNF downregulation

(2014) Carol E. Vásquez et al.   NEUROCHEMISTRY INTERNATIONAL

Maternal influences on fetal microbial colonization and immune development

(2014) Joann Romano-Keeler et al.   PEDIATRIC RESEARCH

Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia

(2014) Elson Asevedo et al.   PHYSIOLOGY & BEHAVIOR

A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice

(2014) Bettina Pyndt Jørgensen et al.   PLoS One

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

(2014) Eleonora Distrutti et al.   PLoS One

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

(2014) Michèle Crumeyrolle-Arias et al.   PSYCHONEUROENDOCRINOLOGY

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

(2014) Ryoko Kibe et al.   Scientific Reports

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

(2013) Caroline M. Forrest et al.   BRAIN RESEARCH

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic insight of schizophrenia: past and future perspectives

(2013) Shweta singh et al.   GENE

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

Time Course Production of Urolithins from Ellagic Acid by Human Gut Microbiota

(2013) Rocío García-Villalba et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2Areceptor is involved

(2013) Alberto Martire et al.   JOURNAL OF NEUROCHEMISTRY

Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder

(2013) Daimei Sasayama et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

(2013) Helene M. Savignac et al.   NEUROCHEMISTRY INTERNATIONAL

NMDA receptor-dependent function and plasticity in inhibitory circuits

(2013) Alexandre W. Moreau et al.   NEUROPHARMACOLOGY

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway

(2013) C.M. Forrest et al.   NEUROSCIENCE

Dietary omega-3 deficiency reduces BDNF content and activation NMDA receptor and Fyn in dorsal hippocampus: Implications on persistence of long-term memory in rats

(2013) Simone Azevedo Bach et al.   NUTRITIONAL NEUROSCIENCE

Microbial Products Induce Claudin-2 to Compromise Gut Epithelial Barrier Function

(2013) Xiaoyu Liu et al.   PLoS One

Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight

(2013) Xueqin Song et al.   SCHIZOPHRENIA RESEARCH

Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder

(2013) Sigrun Hope et al.   SCHIZOPHRENIA RESEARCH

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

(2013) Melissa A. Snyder et al.   Frontiers in Cellular Neuroscience

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

(2013) Laura C. Wieland Brown et al.   PLOS BIOLOGY

Microbial Endocrinology in the Microbiome-Gut-Brain Axis: How Bacterial Production and Utilization of Neurochemicals Influence Behavior

(2013) Mark Lyte   PLoS Pathogens

BDNF and Schizophrenia: From Neurodevelopment to Neuronal Plasticity, Learning, and Memory

(2013) R. Nieto et al.   Frontiers in Psychiatry

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dietary habits of patients with schizophrenia: A self-reported questionnaire survey

(2012) Agustin J. Simonelli-Muñoz et al.   International Journal of Mental Health Nursing

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity

(2012) Mariana Pedrini et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The dietary pattern of patients with schizophrenia: A systematic review

(2012) Salvatore Dipasquale et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice

(2012) Maren Klug et al.   NEUROBIOLOGY OF DISEASE

Microbes and the gut-brain axis

(2012) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mouse Background Strain Profoundly Influences Paneth Cell Function and Intestinal Microbial Composition

(2012) Ajay S. Gulati et al.   PLoS One

Lack of Modulation of Nicotinic Acetylcholine Alpha-7 Receptor Currents by Kynurenic Acid in Adult Hippocampal Interneurons

(2012) Peter Dobelis et al.   PLoS One

Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters

(2012) Kieran J. Davey et al.   PSYCHOPHARMACOLOGY

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

Effects of omega-3 dietary supplement in prevention of positive, negative and cognitive symptoms: A study in adolescent rats with ketamine-induced model of schizophrenia

(2012) Clarissa S. Gama et al.   SCHIZOPHRENIA RESEARCH

Antioxidative Activity of Microbial Metabolites of (−)-Epigallocatechin Gallate Produced in Rat Intestines

(2011) Akiko TAKAGAKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

(2011) James B Adams et al.   BMC GASTROENTEROLOGY

Disordered eating attitudes in Egyptian antipsychotic naive patients with schizophrenia

(2011) Mounir H. Fawzi et al.   COMPREHENSIVE PSYCHIATRY

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

(2011) Caroline G.M. de Theije et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

(2011) Mia Thompson Ray   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus

(2011) Yosuke Yamawaki et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?

(2011) E. O'Sullivan et al.   Beneficial Microbes

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Pyrosequencing study of fecal microflora of autistic and control children

(2010) Sydney M. Finegold et al.   ANAEROBE

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Mode of delivery affects the bacterial community in the newborn gut

(2010) Giacomo Biasucci et al.   EARLY HUMAN DEVELOPMENT

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways

(2010) Amanda Sainsbury et al.   NEUROPEPTIDES

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

(2010) A. K. Benson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia

(2010) Xiaoduo Fan et al.   SCHIZOPHRENIA RESEARCH

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

(2009) Yukiori Goto et al.   BIOLOGICAL PSYCHIATRY

The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis

(2009) Michael C Abt et al.   CURRENT OPINION IN GASTROENTEROLOGY

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

(2009) Stephen M. Collins et al.   GASTROENTEROLOGY

Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications

(2009) Pablo A. Gaspar et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels

(2009) M.H. Selina Mok et al.   NEUROPHARMACOLOGY

Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety

(2009) Brigitta B. Gundersen et al.   NEUROPHARMACOLOGY

Ketamine and the next generation of antidepressants with a rapid onset of action

(2009) Rodrigo Machado-Vieira et al.   PHARMACOLOGY & THERAPEUTICS

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology-driven neurodevelopmental animal models of schizophrenia

(2009) Urs Meyer et al.   PROGRESS IN NEUROBIOLOGY

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

(2008) J. McGrath et al.   EPIDEMIOLOGIC REVIEWS

Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission

(2008) J. J. Arnaiz-Cot et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

BifidobacteriumandLactobacillusDNA in the human placenta

(2008) R. Satokari et al.   LETTERS IN APPLIED MICROBIOLOGY

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Brain foods: the effects of nutrients on brain function

(2008) Fernando Gómez-Pinilla   NATURE REVIEWS NEUROSCIENCE

Context-dependent modulation of αβγ and αβδ GABAA receptors by penicillin: Implications for phasic and tonic inhibition

(2008) Hua-Jun Feng et al.   NEUROPHARMACOLOGY

NMDA receptors inhibit synapse unsilencing during brain development

(2008) H. Adesnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

(2008) Lísia Rejane Guimarães et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY