Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma

Role of the COP1 protein in cancer development and therapy

(2020) Yizuo Song et al.   SEMINARS IN CANCER BIOLOGY

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

(2020) Lisa J. Crawford et al.   ONCOGENE

RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma

(2020) Chunyan Gu et al.   LEUKEMIA

p27 transcriptionally coregulates cJun to drive programs of tumor progression

(2019) Hyunho Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer

(2019) Eun-Ji Ko et al.   Genes & Genomics

Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma

(2019) Yan Song et al.   LEUKEMIA

Kinome expression profiling to target new therapeutic avenues in multiple myeloma

(2019) Hugues de Boussac et al.   HAEMATOLOGICA

Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer

(2019) Lihui Li et al.   EBioMedicine

IKZF1/3 and CRL4-CRBN E3 ubiquitin ligase mutations and IMiD resistance in multiple myeloma

(2019) Santiago Barrio et al.   HAEMATOLOGICA

The NEDD4‐1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma

(2019) Xi Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors

(2019) Omid Fotouhi et al.   ONCOGENE

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

(2019) Sonia Rodriguez et al.   LEUKEMIA

Triterpenic Acids from Potentilla parvifolia and Their Protective Effects against Okadaic Acid Induced Neurotoxicity in Differentiated SH-SY5Y Cells

(2018) Zhen-zhen Yuan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein

(2018) Maryam Abbastabar et al.   DNA REPAIR

Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma

(2018) Reinaldo Franqui-Machin et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling

(2018) Ying Chen et al.   YONSEI MEDICAL JOURNAL

The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines

(2018) Won Hye Ka et al.   Breast Cancer

Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats

(2018) Zhiping Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

p27 inhibits CDK6/CCND1 complex formation resulting in cell cycle arrest and inhibition of cell proliferation

(2018) Niannian Li et al.   CELL CYCLE

Ixazomib for the treatment of multiple myeloma

(2018) Paul G. Richardson et al.   EXPERT OPINION ON PHARMACOTHERAPY

Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas

(2017) Yoh Dobashi et al.   HUMAN PATHOLOGY

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

(2016) Z. Zhang et al.   BLOOD

The non-canonical functions of p27Kip1in normal and tumor biology

(2016) Savitha S. Sharma et al.   CELL CYCLE

E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers

(2016) Kazuma Masumoto et al.   CURRENT CANCER DRUG TARGETS

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

(2016) Ahmad Iskandarani et al.   Journal of Translational Medicine

The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53

(2016) Shenshan Zou et al.   MOLECULAR NEUROBIOLOGY

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

(2016) Monique P C Mulder et al.   Nature Chemical Biology

Regulating the stability and localization of CDK inhibitor p27Kip1via CSN6-COP1 axis

(2015) Hyun Ho Choi et al.   CELL CYCLE

FOXM1 is a therapeutic target for high-risk multiple myeloma

(2015) C Gu et al.   LEUKEMIA

COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth

(2015) Hyun Ho Choi et al.   Oncotarget

COP1 targets C/EBP  for degradation and induces acute myeloid leukemia via Trib1

(2013) A. Yoshida et al.   BLOOD

Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors

(2013) Hongling Zhao et al.   CANCER CELL

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers

(2013) Wen Zhou et al.   CANCER CELL

Loss of COP1 expression determines poor prognosis in patients with gastric cancer

(2013) GENTA SAWADA et al.   ONCOLOGY REPORTS

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

(2011) Domenico Migliorini et al.   JOURNAL OF CLINICAL INVESTIGATION

COP1 is a tumour suppressor that causes degradation of ETS transcription factors

(2011) Alberto C. Vitari et al.   NATURE

Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma

(2010) Y.-H. Lee et al.   CANCER RESEARCH

Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53

(2010) Lan Wang et al.   MOLECULAR BIOLOGY REPORTS

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

(2009) Mai Shimada et al.   CANCER SCIENCE

An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma

(2008) W. Xiong et al.   BLOOD

COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression

(2008) Satomi Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY