The NEDD4‐1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma

Plk1 overexpression induces chromosomal instability and suppresses tumor development

(2018) Guillermo de Cárcer et al.   Nature Communications

NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma

(2017) Zhi-Jun Huang et al.   Oncology Letters

Multiple myeloma

(2017) Shaji K. Kumar et al.   Nature Reviews Disease Primers

NEDD4-1 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis via the PI3K/Akt pathway

(2016) Wei Hu et al.   APOPTOSIS

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis

(2016) Nandini Verma et al.   CANCER RESEARCH

Intestinal knockout of Nedd4 enhances growth of Apcmin tumors

(2016) C Lu et al.   ONCOGENE

Genetics of multiple myeloma: another heterogeneity level?

(2015) J. Corre et al.   BLOOD

NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling

(2015) Yuping Zhang et al.   GYNECOLOGIC ONCOLOGY

Molecular mechanisms in multiple myeloma drug resistance

(2015) Nicholas Nikesitch et al.   JOURNAL OF CLINICAL PATHOLOGY

SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization

(2015) Weihua Zhou et al.   Oncotarget

AKT as a therapeutic target in multiple myeloma

(2014) Niamh A Keane et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis

(2014) Aiqin Sun et al.   Molecular Cancer

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

(2014) Di-Feng Fang et al.   Nature Communications

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

(2014) Taoling Zeng et al.   Cell Reports

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN

(2013) S-W Hong et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

Oncogenic function of p34SEI-1 via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway

(2013) SAMIL JUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Strategy for Modulation of Enzymes in the Ubiquitin System

(2013) A. Ernst et al.   SCIENCE

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

(2012) P Y Liu et al.   CELL DEATH AND DIFFERENTIATION

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

(2012) Peter W. Eide et al.   CELLULAR SIGNALLING

TRAF6 Activation in Multiple Myeloma: A Potential Therapeutic Target

(2012) Hong Liu et al.   Clinical Lymphoma Myeloma & Leukemia

Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response

(2012) Chuan-Dong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line

(2011) Gobind Singh et al.   BMC CANCER

mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif

(2011) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study

(2011) S K Kumar et al.   LEUKEMIA

Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas

(2010) Nicola Amodio et al.   AMERICAN JOURNAL OF PATHOLOGY

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

(2009) Avinash Persaud et al.   Molecular Systems Biology

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Expression of NEDD-1, a PTEN regulator, in gastric and colorectal carcinomas 

(2008) SUNG SOO KIM et al.   APMIS

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation

(2008) Xinjiang Wang et al.   BIOCHEMICAL JOURNAL

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2008) N. Rhodes et al.   CANCER RESEARCH

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

(2008) F. Fouladkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA