The non-canonical functions of p27Kip1in normal and tumor biology

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

(2015) S. Dietrich et al.   BLOOD

p27Kip1 inhibits the cell cycle through non-canonical G1/S phase-specific gatekeeper mechanism

(2015) Savitha S Sharma et al.   CELL CYCLE

Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation

(2015) D Zhao et al.   ONCOGENE

p27kip1controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability

(2015) Linda Fabris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner

(2015) Joshua Armenia et al.   Oncotarget

Genetic characterization of p27kip1and stathmin in controlling cell proliferation in vivo

(2014) Stefania Berton et al.   CELL CYCLE

Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression

(2013) Chia-Hsin Chan et al.   CELL

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

(2013) Gianluca Occhi et al.   PLoS Genetics

p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation

(2012) Han Li et al.   Cell Stem Cell

p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration

(2012) Juliette D. Godin et al.   DEVELOPMENTAL CELL

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1

(2012) M. Perez-Luna et al.   NUCLEIC ACIDS RESEARCH

High cytoplasmic expression of p27Kip1 is associated with a worse cancer-specific survival in clear cell renal cell carcinoma

(2011) Stephan Kruck et al.   BJU INTERNATIONAL

Prognostic Significance of Cytoplasmic p27 Expression in Human Melanoma

(2011) G. Chen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Inhibition of p27Kip1gene transcription by mitogens

(2011) Tapan K. Bagui et al.   CELL CYCLE

The cell cycle inhibitor p27Kip1controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle,BrachyuryandTwist

(2011) Cristina Menchón et al.   CELL CYCLE

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

(2011) R Pippa et al.   ONCOGENE

Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro

(2011) M P Serres et al.   ONCOGENE

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

(2011) Y Cheli et al.   ONCOGENE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

(2010) S. A. Wander et al.   CLINICAL CANCER RESEARCH

A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization

(2010) Sara Molatore et al.   HUMAN MUTATION

p27kip1 Controls Cell Morphology and Motility by Regulating Microtubule-Dependent Lipid Raft Recycling

(2010) B. Belletti et al.   MOLECULAR AND CELLULAR BIOLOGY

SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation

(2010) Vincenzo D’Angiolella et al.   NATURE

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

(2009) A. Kazi et al.   MOLECULAR AND CELLULAR BIOLOGY

The Tumor Suppressor Functions of p27kip1 Include Control of the Mesenchymal/Amoeboid Transition

(2009) S. Berton et al.   MOLECULAR AND CELLULAR BIOLOGY

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

(2009) M. D. Larrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

(2008) Q. Chen et al.   BLOOD

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis

(2008) M. Schiappacassi et al.   MOLECULAR CANCER THERAPEUTICS