Article
Immunology
Xiaolin Wang, Zhou Guo, Jiamin Lin, Kai Sun, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Xiong Zhang, Fengjing Guo, Youxiu Wei
Summary: The aim of this study was to investigate the inhibitory effect of indirubin on arthritis and its cellular-level processes. The results showed that indirubin can reduce chondrocyte inflammation and improve cartilage degradation. It also inhibited the abnormal activation of NF-Kappa B and MAPK signaling pathways. These findings suggest the potential of indirubin as an anti-arthritis drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haokun Mo, Siying Yang, An -min Chen
Summary: GAB2 plays an important role in osteoarthritis, and inhibition of GAB2 expression can reduce the expression of inflammatory proteins and inhibit the activation of key signaling pathways. In animal experiments, reducing GAB2 expression can delay cartilage destruction. Therefore, GAB2 is a potential therapeutic target for osteoarthritis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Huan Yang, Zhengting Wang, Lihuan Wang, Yijie Li, Jiadong Guo, Xiao Yang, Jie Zhao, Kewei Rong, Pu Zhang, Bin Ye, Kai Zhang, Hui Ma
Summary: Osteoarthritis is a chronic degenerative disease that greatly affects the quality of life among the elderly. Scutellarin, derived from Erigeron breviscapus, has shown anti-inflammatory effects, making it a potential treatment for osteoarthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Junlai Wan, Ziqing Zhu, Zhiyi He, Hua Wu, Anmin Chen, Wentao Zhu, Peng Cheng
Summary: Stevioside (SVS) might alleviate cartilage degradation in mice with osteoarthritis (OA) by inhibiting the expression of inflammatory cytokines, reducing cell apoptosis and improving autophagy, as well as blocking the activation of signaling pathways. In vivo experiments demonstrated the potential therapeutic effect of SVS on OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Ximiao Chen, Zhengli Li, Haofeng Hong, Ning Wang, Junyi Chen, Sisi Lu, Hongyuan Zhang, Xiaolei Zhang, Chaoyong Bei
Summary: The research found that Xanthohumol (XN) can inhibit the expression of nitric oxide synthase (INOS), IL-1 beta-promoted inducible nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. Additionally, it down-regulates matrix metalloproteinase-13 and prothrombin, while up-regulating type II collagen and Aggrecan expression. XN also activates nuclear factor (Nrf2) and inhibits nuclear factor B (NF-kappaB) signal transduction to slow down the progression of osteoarthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Shida Lin, Jiajie Lua, Qiaoxue Chen, Hongyi Jiang, Chao Lou, Chihao Lin, Weidan Wang, Jian Lin, Xiaoyun Pan, Xinghe Xue
Summary: Plantamajoside has potential as an anti-OA therapeutic candidate by inhibiting inflammatory factors and slowing the progression of cartilage and joint degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Plant Sciences
Huan Yu, Sai Yao, Chengchong Zhou, Fangda Fu, Huan Luo, Weibin Du, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Hongfeng Ruan
Summary: The study demonstrated that morroniside can attenuate the progression of osteoarthritis in mice by promoting cartilage matrix synthesis, inhibiting chondrocyte pyroptosis, reducing osteophyte formation, and subchondral sclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Yiping Mu, Yang Zhang, Jie Wu, Qi Li
Summary: NLRC5 is a critical mediator of inflammatory response and its overexpression in chondrocytes suppressed IL-1β-induced inflammation. Knockdown of NLRC5 had the opposite effect. NLRC5 attenuated IL-1β-induced inflammatory injury through regulating the NF-κB signaling pathway in chondrocytes.
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yi Cheng, Feng Li, Wen-Sheng Zhang, Guo-You Zou, Yi-Xin Shen
Summary: The study reveals that silencing BLNK can delay the progression of OA and IL-1 beta-induced chondrocyte injury by regulating the NF Kappa B pathway.
Article
Biotechnology & Applied Microbiology
Yeli Zhou, Jing Li, Chenglong Wang, Zheer Pan
Summary: The study discovered that fumitremorgin C alleviates inflammation and extracellular matrix degradation induced by AGE through the activation of the SIRT1/NF-kappa B/MAPK pathway, thus preventing the progression of osteoarthritis.
Review
Immunology
Zicong Lin, Zhiqin Deng, Jianquan liu, Zhongshi Lin, Siyu Chen, Zhenhan Deng, Wencui Li
Summary: Articular cartilage plays a crucial role in absorbing stress during exercise. Chondrocytes are the metabolic center of articular cartilage, maintaining a dynamic balance of extracellular matrix. Research on chloride channels in chondrocytes has revealed their significance in physiological and pathological processes, impacting cartilage metabolism and inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Orthopedics
Qiang Shi, Tao Zhang, Yang Chen, Yan Xu, Zhenhan Deng, Daqi Xu
Summary: The study found that metformin can induce osteogenesis of canine BMSCs in vitro and local administration of metformin can improve bone microarchitecture and increase the tensile properties of the repaired ATC interfaces in canines.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Oncology
Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu, Wencui Li
Summary: In this study, potential biomarkers for predicting the prognosis of breast cancer were identified through the analysis of gene expression data. ANLN and UBE2T were found to be upregulated in breast cancer and their upregulation was associated with a poor prognosis. Furthermore, their upregulation was associated with the prevalence of specific immune cells.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yi-Zi Zheng, Yan Liu, Zhen-Han Deng, Guo-Wen Liu, Ni Xie
Summary: Prognostic factors and optimal surgical intervention for early-onset triple-negative breast cancer (eTNBC) have been understudied. This study identified marital status, insurance status, histological type, T stage, and N stage as important prognostic factors for eTNBC patients. A prognostic nomogram based on these factors was developed. Subgroup analysis showed that breast-conserving therapy may be a better option for patients with T1N0M0 and T2-4N+M0 tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Zirong Huang, Jiaming Cui, Mingjin Zhong, Zhenhan Deng, Kang Chen, Weimin Zhu
Summary: Anterior cruciate ligament injury is the most common sports injury, affecting knee joint function and exercise. Surgical reconstruction is the preferred treatment, but can lead to articular cartilage injury and osteoarthritis. This review explores the factors influencing cartilage lesions after anterior cruciate ligament reconstruction, providing insights for delaying and preventing osteoarthritis progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
Ya Song, Ping Li, Yan Xu, Zhangyuan Lin, Zhenhan Deng, Can Chen
Summary: Human MenSCs encapsulated in autologous platelet-rich gel (APG) promote the healing of chronic rotator cuff tears by enhancing the formation of new bone tissue and regenerating mature fibrocartilage. This treatment also improves the mechanical properties of the repaired cuff.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yizi Zheng, Zhenhan Deng, Feijuan Huang, Yu Zhang, Yuanzhe Cai, Jingyue Su, Zhengzhi Wu, Shiwei Yang
Summary: This study analyzed the transmission patterns and clinical course of the first wave of COVID-19 infection in Shenzhen, China. The results showed that the clustered group had more young and old patients compared to the non-clustered group, and the clustered group had more severe cases. Patients with severe disease required longer hospitalization compared to patients with moderate and mild disease.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Wenhao Lu, Zhenhan Deng, Anko Elijah Essien, Djandan Tadum Arthur Vithran, Michael Opoku, Yusheng Li, Wenfeng Xiao
Summary: Knee ligament injuries, particularly the anterior cruciate ligament, are commonly treated with ligament repair or reconstruction. The internal brace technique, using braided ultra-high-molecular-weight polyethylene suture tapes, aims to enhance the strength of tendon grafts and improve postoperative rehabilitation outcomes. This review examines the research progress, biomechanical and histological findings, and clinical studies related to the internal brace ligament augmentation technique.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Xinyu Li, Leyao Shen, Zhenghan Deng, Zeyu Huang
Summary: Osteoarthritis is a degenerative disease that affects the entire joint tissue. Non-surgical treatments for osteoarthritis focus on relieving pain, but surgery is often necessary for end-stage cases. Gene therapy offers a promising alternative to delay progression and promote cartilage repair in osteoarthritis by delivering therapeutic genes. This review discusses the history, expression vectors, gene delivery methods, and potential of CRISPR/Cas9 gene editing in osteoarthritis, as well as the current challenges and possible solutions for clinical translation of gene therapy.
PRECISION CLINICAL MEDICINE
(2023)
Article
Pathology
Chao Cheng, Ye Tian, Ruiqi Yang, Wei Guo, Kai Xiao, Fangjie Zhang, Jian Tian, Zhenhan Deng, Wenjian Yang, Hua Yang, Zhihong Zhou
Summary: This study found that miR-5581 was significantly up-regulated in OA samples and IL-113-stimulated chondrocytes, and miR-5581-associated genes were enriched in Kras signaling. Up-regulation of miR-5581 inhibited cell proliferation, extracellular matrix (ECM) synthesis, and promoted ECM degradation by targeting NRF1, where Kras signaling might be involved. NRF1 was down-regulated in knee joint cartilage of OA mice.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Shengyuan Zheng, Senbo An, Yan Luo, Djandan Tadum Arthur Vithran, Shaoqu Yang, Bangbao Lu, Zhenhan Deng, Yusheng Li
Summary: HYBID is a new enzyme that degrades hyaluronan and is present in various cells of the human body. Recent research has found that HYBID is over-expressed in chondrocytes and synoviocytes associated with osteoarthritis. High levels of HYBID are significantly correlated with cartilage degeneration and hyaluronic acid degradation in the joints. Additionally, HYBID can contribute to inflammatory responses and tissue fibrosis in the joints, exacerbating osteoarthritis. Understanding the role of HYBID in osteoarthritis could provide new insights for treatment strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Emergency Medicine
Zhenhan Deng, Wei Lu, Cailong Liu, Shuguang Gao, Lichuang Wu, Yiheng Ye, Jingyue Su, Jian Xu
Summary: Treatment algorithms for anterior shoulder instability should consider various factors, including glenoid and humeral bone loss and scores such as the ISIS score. However, there is currently no evidence-based consensus due to limited evaluation of these factors. This study aims to summarize the surgical options for treating glenoid bone loss in anterior shoulder instability.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Review
Cell Biology
Jianfeng Sun, Yibo Tan, Jingyue Su, Herasimenka Mikhail, Volotovski Pavel, Zhenhan Deng, Yusheng Li
Summary: Ghrelin is a brain-gut peptide that can promote the release of growth hormone, potentially playing a role in bone growth and development. Recent studies have reported a correlation between ghrelin and degenerative diseases of the musculoskeletal system, suggesting that ghrelin may be a factor influencing degenerative pathologies. With the aging population, the risk of health problems caused by degenerative diseases of the musculoskeletal system increases. This article summarizes the roles of ghrelin in musculoskeletal disorders, highlighting the potential effects of ghrelin as a key target in the treatment of related bone and muscle diseases and the need for further research.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Orthopedics
Hao Li, Wei Lu, Zhenhan Deng
Summary: Arthroscopic techniques for anterior talofibular ligament (ATFL) reconstruction have been developed, and the socket-anchor technique for talar tunnel creation provides advantages of being minimally invasive, ensuring a sufficient tendon-bone interface healing area, and having no special restrictions on the direction of the anchor.
ARTHROSCOPY TECHNIQUES
(2023)
Article
Medicine, General & Internal
Hongfu Jin, Miao He, Wenqing Xie, Zixuan Xiong, Zhenhan Deng, Yusheng Li
Summary: This study conducts a bibliometric analysis to identify valuable publications, influential journals, leading researchers, and core countries in the field of patient-reported outcome measures (PROMs) in orthopedic research. The results show that the United States has made significant contributions to orthopedic-related PROMs and that PROMs are increasingly popular in both clinical practice and academic research. The analysis also indicates the potential for using network-based or short message service (SMS)-based electronic PROMs in orthopedic medical practices, as well as their role in psychological and mental health research and telemedicine.
MEDICINA-LITHUANIA
(2023)