Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity

(2018) Wilson Castro et al.   NATURE IMMUNOLOGY

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

(2018) Róisín M. Loftus et al.   Nature Communications

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

(2018) Giorgia Rota et al.   Cell Reports

mTORC1 and mTORC2 differentially promote natural killer cell development

(2018) Chao Yang et al.   eLife

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

(2017) Charlotte Viant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

(2016) Rebecca B. Delconte et al.   IMMUNITY

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway

(2016) M Y Cherepkova et al.   Cell Death & Disease

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

(2016) Meixiang Yang et al.   Nature Communications

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Recognition and Regulation of T Cells by NK Cells

(2016) Katharina Pallmer et al.   Frontiers in Immunology

SHP2 sails from physiology to pathology

(2015) Mylène Tajan et al.   European Journal of Medical Genetics

Functions of Shp2 in cancer

(2015) Jie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

(2015) Meixiang Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SHIP1 Intrinsically Regulates NK Cell Signaling and Education, Resulting in Tolerance of an MHC Class I–Mismatched Bone Marrow Graft in Mice

(2015) Matthew Gumbleton et al.   JOURNAL OF IMMUNOLOGY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

(2014) Charlotte Viant et al.   Nature Communications

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

(2013) P. E. Lapinski et al.   Disease Models & Mechanisms

Unraveling the molecular events leading to the genesis of large granular lymphocytic leukemia reveals a new treatment strategy

(2013) T. A. Fehniger   HAEMATOLOGICA

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Regulation of Mouse NK Cell Development and Function by Cytokines

(2013) Antoine Marçais et al.   Frontiers in Immunology

Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice

(2012) S. Belanger et al.   BLOOD

Mouse natural killer cell development and maturation are differentially regulated by SHIP-1

(2012) C. Banh et al.   BLOOD

Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

(2012) Anjali Mishra et al.   CANCER CELL

Tuning the threshold of natural killer cell responses

(2012) Emilie Narni-Mancinelli et al.   CURRENT OPINION IN IMMUNOLOGY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

(2012) N. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation and function of the RSK family of protein kinases

(2011) Yves Romeo et al.   BIOCHEMICAL JOURNAL

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

(2011) G. Chan et al.   BLOOD

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia

(2011) W. Warsch et al.   BLOOD

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

(2011) E. Narni-Mancinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development

(2010) E. Eckelhart et al.   BLOOD

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

(2009) William E Tidyman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education

(2009) Anick Chalifour et al.   IMMUNITY

NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model

(2009) N. T. Joncker et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development

(2009) K. S. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell education: not an on-off switch but a tunable rheostat

(2009) Petter Brodin et al.   TRENDS IN IMMUNOLOGY

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA