Functions of Shp2 in cancer

The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration

(2015) Michelle A. Edwards et al.   JOURNAL OF APPLIED PHYSIOLOGY

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

(2015) Namit Sharma et al.   Oncotarget

Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis

(2014) Hsueh-Chun Wang et al.   BMC CANCER

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice

(2014) Valentina E. Schneeberger et al.   CARCINOGENESIS

SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1

(2014) Shuomin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells

(2014) C. M. Furcht et al.   JOURNAL OF CELL SCIENCE

Alterations of cell cycle control proteins SHP-1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells

(2014) GANG PENG et al.   Molecular Medicine Reports

Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases

(2014) N Sausgruber et al.   ONCOGENE

Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma

(2014) ZHONGQIAN HU et al.   ONCOLOGY REPORTS

Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling

(2014) Liza D. Morales et al.   PLoS One

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity

(2014) Mylène Tajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach

(2014) Yu-Qing Duan et al.   PROTEIN AND PEPTIDE LETTERS

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

(2013) Jie Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma

(2013) Li Zhang et al.   HEPATOLOGY

SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer

(2013) JIA GU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

(2013) Zamal Ahmed et al.   JOURNAL OF CELL BIOLOGY

Expression and Clinical Significance of SHP2 in Gastric Cancer

(2013) S Dong et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11)

(2013) Wei Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility

(2013) X. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Tyrosine Phosphatase SHP2 Regulates Focal Adhesion Kinase to Promote EGF-Induced Lamellipodia Persistence and Cell Migration

(2013) Zachary R. Hartman et al.   MOLECULAR CANCER RESEARCH

Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies

(2013) B. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase

(2013) K Miura et al.   ONCOGENE

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains

(2013) F. Sha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro

(2013) Hongjun Xie et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Expression of SHP2 and Related Markers in Non–Small Cell Lung Cancer

(2013) Chunlan Tang et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia

(2012) D. Buet et al.   BLOOD

Shp2 function in hematopoietic stem cell biology and leukemogenesis

(2012) Sarah C. Nabinger et al.   CURRENT OPINION IN HEMATOLOGY

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

(2012) Xue Zhang et al.   FASEB JOURNAL

Regulation of SHP2 by PTEN/AKT/GSK-3β signaling facilitates IFN-γ resistance in hyperproliferating gastric cancer

(2012) Po-Chun Tseng et al.   IMMUNOBIOLOGY

Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts

(2012) Y.-R. Pan et al.   JOURNAL OF CELL SCIENCE

Expression and significance of SHP-2 in human papillomavirus infected cervical cancer

(2012) Fei Meng et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production

(2012) Fei Meng et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints

(2012) Yiu Huen Tsang et al.   PLoS One

A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells

(2011) L. Li et al.   BLOOD

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

(2011) G. Chan et al.   BLOOD

Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma

(2011) L-M Sturla et al.   BRITISH JOURNAL OF CANCER

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver

(2011) Ma. Eugenia Díaz et al.   CELLULAR SIGNALLING

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

(2010) D. Xu et al.   BLOOD

Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations

(2010) Matthew J. Lazzara et al.   CANCER RESEARCH

Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis

(2010) Johan Lennartsson et al.   CELLULAR SIGNALLING

Helicobacter pyloriCagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells

(2010) In Ohk Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHP2 Mediates the Localized Activation of Fyn Downstream of the  6 4 Integrin To Promote Carcinoma Invasion

(2010) X. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation

(2010) Hsiao-Ling Cheng et al.   Molecular Cancer

Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation

(2009) Ju Li et al.   EXPERIMENTAL CELL RESEARCH

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1

(2009) Luyang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism for SHP2 in Promoting HER2-induced Signaling and Transformation

(2009) Xiangdong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of Stat3 by ActivatingPTPN11Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia

(2009) Wenjun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells

(2008) X-D Zhou et al.   CELL DEATH AND DIFFERENTIATION

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

(2008) Zhenyun Yang et al.   EXPERIMENTAL HEMATOLOGY

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

(2008) X Zhou et al.   HISTOPATHOLOGY

Aqueous Extract of Arbutus unedo Inhibits STAT1 Activation in Human Breast Cancer Cell Line MDA-MB-231 and Human Fibroblasts Through SHP2 Activation

(2008) S. Mariotto et al.   Medicinal Chemistry

S100A7-Downregulation Inhibits Epidermal Growth Factor-Induced Signaling in Breast Cancer Cells and Blocks Osteoclast Formation

(2008) Vikram Paruchuri et al.   PLoS One

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA