Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

(2021) Anteneh Marelign Beyene et al.   Nanomaterials

Inflammatory bowel disease: between genetics and microbiota

(2020) Nour Younis et al.   MOLECULAR BIOLOGY REPORTS

Nanocurcumin: A Promising Candidate for Therapeutic Applications

(2020) Adhimoolam Karthikeyan et al.   Frontiers in Pharmacology

Colon targeted bioadhesive pellets of curcumin and cyclosporine for improved management of inflammatory bowel disease

(2020) Neha Desai et al.   Drug Delivery and Translational Research

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

(2020) Mohammad Moniruzzaman et al.   Pharmaceutics

Curcumin nanocrystal/pH-responsive polyelectrolyte multilayer core-shell nanoparticles for inflammation-targeted alleviation of ulcerative colitis

(2020) Murtada A. Oshi et al.   BIOMACROMOLECULES

Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease

(2020) Tripti Khare et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly Bioavailable Curcumin Derivative Ameliorates Crohn’s Disease Symptoms: A Randomized, Double-Blind, Multicenter Study

(2020) Ken Sugimoto et al.   Journal of Crohns & Colitis

Novel Bioenhanced Curcumin With Mesalamine for Induction of Clinical and Endoscopic Remission in Mild-to-Moderate Ulcerative Colitis

(2020) Rupa Banerjee et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

(2020) Dominik Rotrekl et al.   CARBOHYDRATE POLYMERS

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

(2019) Sita Sharan Patel et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Curcumin ameliorates dextran sulfate sodium-induced colitis in mice via regulation of autophagy and intestinal immunity

(2019) Wenjie Yue et al.   Turkish Journal of Gastroenterology

Improved uptake and therapeutic intervention of curcumin via designing binary lipid nanoparticulate formulation for oral delivery in inflammatory bowel disorder

(2019) Manu Sharma et al.   Artificial Cells Nanomedicine and Biotechnology

Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice

(2019) Lize Zhang et al.   Molecular Medicine Reports

Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease

(2019) Mirabella Zhao et al.   DIGESTIVE DISEASES AND SCIENCES

The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis

(2019) Gábor J. Szebeni et al.   MOLECULES

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

(2019) Shameemah Abrahams et al.   NEUROSCIENCE

Curcumin: a modulator of inflammatory signaling pathways in the immune system

(2019) Kolsoum Rezaie Kahkhaie et al.   INFLAMMOPHARMACOLOGY

Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet

(2019) Macha Samba-Mondonga et al.   PLoS One

Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn's Disease After Surgery in a Randomized Controlled Trial

(2019) Gilles Bommelaer et al.   Clinical Gastroenterology and Hepatology

The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis

(2019) Narges Sadeghi et al.   PHYTOTHERAPY RESEARCH

Facile fabrication of bowl-shaped microparticles for oral curcumin delivery to ulcerative colitis tissue

(2018) Qiubing Chen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression

(2018) Min Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases?

(2018) Rafaela Mazieiro et al.   JOURNAL OF MEDICINAL FOOD

Impact of curcumin nanoformulation on its antimicrobial activity

(2018) Anderson Clayton da Silva et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

(2018) Yukihide Momozawa et al.   Nature Communications

Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis

(2018) Yiqing Wang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Site-directed polymer-drug complexes for inflammatory bowel diseases (IBD): Formulation development, characterization, and pharmacological evaluation

(2018) Siddharth S. Kesharwani et al.   JOURNAL OF CONTROLLED RELEASE

Curcumin as an anti-inflammatory agent: Implications to radiotherapy and chemotherapy

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oral administration of colitis tissue-accumulating porous nanoparticles for ulcerative colitis therapy

(2018) Qiubing Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Encapsulation in egg white protein nanoparticles protects anti-oxidant activity of curcumin

(2018) Cuihua Chang et al.   FOOD CHEMISTRY

Development and characterization of anti-inflammatory activity of curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders

(2017) E. Blanco-García et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structure–Activity Relationship of Curcumin: Role of the Methoxy Group in Anti-inflammatory and Anticolitis Effects of Curcumin

(2017) Haixia Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis

(2017) Mei Yang et al.   Molecular Pain

Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage

(2017) Claudia Loganes et al.   Nutrients

New Frontiers in Genetics, Gut Microbiota, and Immunity: A Rosetta Stone for the Pathogenesis of Inflammatory Bowel Disease

(2017) Mingxia Zhou et al.   Biomed Research International

Of mice and men: a novel dietary supplement for the treatment of ulcerative colitis

(2017) Shiran Shapira et al.   Therapeutic Advances in Gastroenterology

Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

(2017) Duk Hwan Kim et al.   Immune Network

Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells

(2017) Masashi Ohno et al.   PLoS One

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis

(2017) Shusuke Toden et al.   Scientific Reports

Genetics and Pathogenesis of Inflammatory Bowel Disease

(2016) Ta-Chiang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease

(2016) Ana Beloqui et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Wound Healing Effects of Curcumin: A Short Review

(2016) Silvia Tejada et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease

(2016) Remya Sreedhar et al.   DRUG DISCOVERY TODAY

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

(2016) Floris Imhann et al.   GUT

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

(2016) Srinivas Mutalik et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A combined omics approach to evaluate the effects of dietary curcumin on colon inflammation in the Mdr1a−/− mouse model of inflammatory bowel disease

(2016) Janine M. Cooney et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis

(2016) Hai-Mei Zhao et al.   Frontiers in Pharmacology

Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial

(2015) Alon Lang et al.   Clinical Gastroenterology and Hepatology

Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy

(2015) Bo Xiao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients With Very Early Onset Inflammatory Bowel Disease

(2015) Judith R. Kelsen et al.   GASTROENTEROLOGY

Genetics of Inflammatory Bowel Diseases

(2015) Dermot P.B. McGovern et al.   GASTROENTEROLOGY

Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis

(2015) C.-P. Li et al.   GENETICS AND MOLECULAR RESEARCH

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants

(2015) Sung Noh Hong et al.   GUT

The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

(2015) Rita-Marie T. McFadden et al.   INFLAMMATORY BOWEL DISEASES

Curcumin–piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapy

(2015) Qiuping Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cape Gooseberry [Physalis peruvianaL.] Calyces Ameliorate TNBS Acid-induced Colitis in Rats

(2015) Jenny Castro et al.   Journal of Crohns & Colitis

Clinical Features of Interleukin 10 Receptor Gene Mutations in Children With Very Early–Onset Inflammatory Bowel Disease

(2015) Omer F. Beser et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

(2015) Fabiana Andréa Moura et al.   Redox Biology

Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts

(2014) Kyriaki Zikaki et al.   APOPTOSIS

Curcumin: A Double Hit on Malignant Mesothelioma

(2014) J. M. Miller et al.   Cancer Prevention Research

pH triggered delivery of curcumin from Eudragit-coated chitosan microspheres for inflammatory bowel disease: characterization and pharmacodynamic evaluation

(2014) Rashmi Sareen et al.   DRUG DELIVERY

Early-onset Crohn’s disease and autoimmunity associated with a variant in CTLA-4

(2014) Sebastian Zeissig et al.   GUT

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

(2014) N Waugh et al.   HEALTH TECHNOLOGY ASSESSMENT

pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease

(2014) Ana Beloqui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target

(2014) FENG ZHAO et al.   Molecular Medicine Reports

Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments

(2014) Liza Vecchi Brumatti et al.   MOLECULES

Advances in IBD genetics

(2014) Johan Van Limbergen et al.   Nature Reviews Gastroenterology & Hepatology

The Effect of Turmeric (Curcuma longa) Extract on the Functionality of the Solute Carrier Protein 22 A4 (SLC22A4) and Interleukin-10 (IL-10) Variants Associated with Inflammatory Bowel Disease

(2014) Mark McCann et al.   Nutrients

Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease: Fabrication, Optimization, andIn Vitroand Pharmacodynamic Evaluation

(2014) Rashmi Sareen et al.   Biomed Research International

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

(2013) A. P. Hutchins et al.   Briefings in Functional Genomics

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Genetic Susceptibility in IBD

(2013) James D. Doecke et al.   INFLAMMATORY BOWEL DISEASES

Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis — A randomized, placebo-controlled, pilot study

(2013) Vikas Singla et al.   Journal of Crohns & Colitis

Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid–Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase

(2013) Yeter Topcu-Tarladacalisir et al.   JOURNAL OF MEDICINAL FOOD

pH-Sensitive Nanoparticles of Curcumin–Celecoxib Combination: Evaluating Drug Synergy in Ulcerative Colitis Model

(2013) Dalapathi Gugulothu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease

(2012) Tarek Kamal Motawi et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Curcumin inhibits interferon-γ signaling in colonic epithelial cells

(2011) Monica T. Midura-Kiela et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant inNCF2that results in reduced binding to RAC2

(2011) Aleixo M Muise et al.   GUT

Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice

(2011) Souad Mouzaoui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy

(2011) Vivian Soetikno et al.   Nutrition & Metabolism

Adverse effects of biologics used for treating IBD

(2010) Andreas Stallmach et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

T1234 Active Therapeutic Immunization Against TNF With a TNF-Kinoid in Crohn's Disease Patients: A Phase 1-2 Study

(2010) Gerhard Rogler et al.   GASTROENTEROLOGY

Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease

(2010) Vivek Ramshankar Yadav et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model

(2009) Vivek R. Yadav et al.   AAPS PHARMSCITECH

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

(2009) Teayoun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1β and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease

(2009) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

(2009) Vineeta Tanwar et al.   CELL BIOCHEMISTRY AND FUNCTION

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent

(2008) Claire Billerey-Larmonier et al.   INFLAMMATORY BOWEL DISEASES

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis

(2008) A. Lubbad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

(2008) Amanda M Gonzales et al.   Nutrition & Metabolism

Role of mucosal dendritic cells in inflammatory bowel disease

(2008) Jan Hendrik Niess   WORLD JOURNAL OF GASTROENTEROLOGY

Role of cytokines in inflammatory bowel disease

(2008) Fausto Sanchez-Muñoz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY

Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain

(2007) M BISHNOI et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR