Article
Materials Science, Multidisciplinary
Byung-Chul Lee, Jin Young Lee, Juhee Kim, Nari Shin, Je Min Yoo, Insung Kang, Jae-Jun Kim, Seung-Eun Lee, Donghoon Kim, Soon Won Choi, Byung Hee Hong, Kyung-Sun Kang
Summary: Graphene-based nanomaterials, particularly graphene quantum dots (GQDs), have shown promising potential as alternative drugs for rare diseases due to their high biocompatibility and low toxicity. Oral administration of GQDs was demonstrated to effectively ameliorate colitis symptoms without harmful effects, highlighting its potential as a microbiome-friendly treatment option for colitis.
Article
Biochemistry & Molecular Biology
Shu-Ting Miao, Qian-Shan Lu, Ying-Jun Zhou, Ya-Ning Chang, Tao Xu, Meng-Yu Zhu
Summary: Research has shown that octacosanol can alleviate ulcerative colitis by modulating the gut microbiota and promoting gut barrier integrity. This study provides a theoretical basis for the development of functional foods to alleviate ulcerative colitis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Peiyao Wu, Siyu Yao, Xing Wang, Long Yang, Siling Wang, Wenbing Dai, Hua Zhang, Bing He, Xueqing Wang, Shujun Wang, Qiang Zhang
Summary: This study developed orally administrated IND nanoparticles (IND-NPs) for the treatment of ulcerative colitis (UC) and investigated their functions and mechanisms in cellular and animal inflammatory models. The IND-NPs were found to improve UC-associated symptoms, inhibit inflammatory response, and preserve intestinal barrier integrity through regulating intercellular junctions and restoring mitochondrial dysfunction, showing a promising potential in UC treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Akihito Nakajima, Tomoyoshi Shibuya, Takashi Sasaki, Yu Jie Lu, Dai Ishikawa, Keiichi Haga, Masahito Takahashi, Naoko Kaga, Taro Osada, Nobuhiro Sato, Akihito Nagahara
Summary: This study found that oral administration of nicotine increased the levels of indole in the distal colon and rectum, while leading to an attenuation of DSS-induced colitis. The SCFA values in different parts of the intestines did not show significant changes with nicotine administration. Microbiome analysis revealed an increase in certain bacterial groups in the feces of mice administered with nicotine.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Meng Li, Hao Wu, Shuang Wang, Shengshun Wu, Jing Han, Yang Han
Summary: In this study, a pH-dependent drug delivery method using polymer cellulose acetate was developed to deliver active components to the inflamed colon for the treatment of ulcerative colitis, avoiding degradation in the stomach.
Article
Pharmacology & Pharmacy
Dingpei Long, Zahra Alghoul, Junsik Sung, Chunhua Yang, Didier Merlin
Summary: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease, increases the risk of colitis-associated cancer (CAC). The M13-nano-liposome (NL) formulation has been found to effectively prevent chronic UC. This study demonstrates that oral administration of M13-NL prevents tumor development in AOM-exposed IL10-/- mice, suggesting its potential for preventing CAC.
Article
Pharmacology & Pharmacy
Xiao Wang, Li Fu, Weijian Cheng, Jiamei Chen, Huan Zhang, Huanjun Zhu, Chen Zhang, Chaomei Fu, Yichen Hu, Jinming Zhang
Summary: This study focuses on the development and characterization of a nanoemulsion called HLHPEN, which can co-deliver multiple phytochemicals to enhance the anti-ulcerative colitis effects. The optimized HLHPEN showed good physical stability and gradual release of phytochemicals, making it resistant to the destruction of the stomach and small intestine environment. In a DSS-induced UC mice model, oral administration of HLHPEN significantly improved colon tissue length, reduced body weight, ameliorated disease activity index and colon histological pathology, indicating its therapeutic potential as an alternative UC agent.
Article
Biotechnology & Applied Microbiology
Cui Liu, Xiangji Yan, Yujie Zhang, Mei Yang, Yana Ma, Yuanyuan Zhang, Qiuran Xu, Kangsheng Tu, Mingzhen Zhang
Summary: The study suggests that TDNPs 2 derived from turmeric are a novel and natural colon-targeting therapeutics that may prevent colitis and promote wound repair in colitis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nermin M. Sheta, Sylvia A. Boshra
Summary: The study investigated the effects of Celecoxib solubility, concentration, and dispersability on its release, absorption, and biological performance in oleogel formulations. Among the formulations, F3 showed the highest release and stability, leading to a significant increase in drug permeation across the rat intestine. Furthermore, the oleogel formulation demonstrated anti-inflammatory effects and promoted intestinal healing in rats with ulcerative colitis.
Article
Engineering, Biomedical
Hao Liu, Yujie Zhang, Mingzhen Zhang, Zhaoxiang Yu, Mingxin Zhang
Summary: Platinum nanoparticles (Pt NPs) with enzyme-like activities can eliminate excessive reactive oxygen species (ROS) and alleviate ulcerative colitis (UC) symptoms in a colitis model. The oral administration of Pt NPs shows promising therapeutic potential for long-term inflammatory remission.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chao Deng, Yiwei Hu, Mariana Conceicao, Matthew J. A. Wood, Hongyao Zhong, Yan Wang, Ping Shao, Jinghua Chen, Lipeng Qiu
Summary: A LbL-Exos self-assembly system was constructed for the oral delivery of exosomes targeted to the colon. The system protected the exosomes from degradation and effectively alleviated ulcerative colitis through anti-inflammatory and tissue repair effects. Additionally, it improved UC via MAPK/NF-kappa B signaling pathway inhibition.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Stefania De Santis, Aurelia Scarano, Marina Liso, Francesco Maria Calabrese, Giulio Verna, Elisabetta Cavalcanti, Annamaria Sila, Antonio Lippolis, Maria De Angelis, Angelo Santino, Marcello Chieppa
Summary: The health status of mother microbiota has a significant impact on the neonatal gut microbiota. Using a murine model of UC predisposition, this study evaluated the effects of maternal diet during pregnancy and lactation on offspring microbiota, indicating that a diet enriched with bioactive polyphenols from tomato can reduce dysbiosis in genetically predisposed offspring.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Polymer Science
Lin Xia, Jiafeng Meng, Yuan Ma, Ping Zhao
Summary: Shape memory Eucommia rubber composites were processed with both carbon-carbon and ionic cross-linking networks, demonstrating excellent mechanical and shape memory properties under analytical techniques. DCP and ZDMA played crucial roles in enhancing the performance of the composites.
Article
Cell & Tissue Engineering
Li Zhang, Longfei Yu, Yueguang Wei
Summary: It was found that oral administration of NPCTS could accumulate in the colon of colitis mice, significantly improve inflammation symptoms, reduce levels of inflammatory cytokines in the colon, decrease the proportion of total macrophages, and increase the proportion of M2-like macrophages.
CELLULAR AND MOLECULAR BIOENGINEERING
(2022)
Article
Biophysics
Ya Tao, Xin Zhao, XiaoPan Liu, PeiJia Wang, YinMo Huang, RuoNan Bo, MingJiang Liu, JinGui Li
Summary: This study developed a stable nanoemulsion loaded with ARS using a double emulsification solvent volatilisation method. The results demonstrated that CPA nanoemulsion had suitable characteristics for drug release and effectively relieved symptoms of UC in a mouse model. The study also found that CPA could specifically target colonic tissue and alleviate UC.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yi Lu, Die Jia, Xianbin Ma, Mengyun Liang, Shengxin Hou, Wei Qiu, Yuan Gao, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: A stimuli-responsive prodrug nanogel was developed using a two-in-one cross-linking strategy to deliver a combination of chemotherapeutic drugs for improving the deficiencies of chemotherapy and enhancing cancer therapeutic efficiency. The high drug loading capacity and suitable nanoscale size of the obtained nanogel facilitate cell uptake and tumor penetration, leading to enhanced tumor growth inhibition by the synergistic DNA damage in response to the reductive tumor microenvironment. This unique prodrug nanogel shows promise as a candidate for effective tumor treatment-based chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yong-E Gao, Shengxin Hou, Jiaqi Cheng, Xinyi Li, Yongqiong Wu, Yuran Tang, Yanke Li, Peng Xue, Yuejun Kang, Zhigang Xu, Mingming Guo
Summary: Nanotheranostic systems are expected to enhance the efficacy of photodynamic therapy (PDT) by overcoming the limitations of conventional PDT. In this study, silk sericin-based nanoparticles (SSC NPs) were designed and shown to have improved intracellular uptake efficiency and anticancer effects compared to free Ce6.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Mengyun Liang, Yuan Gao, Wei Qiu, Mengjie Ye, Junfeng Hu, Jiming Xu, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: This study introduces an acid-sensitive supramolecular nanoassembly, which enhances therapeutic efficacy by conquering physiological blockages and achieves deep intratumor infiltration in the tumor microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Shiyan Fu, Ruihao Yang, Junjie Ren, Jiahui Liu, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities are synthesized as bioreactors responsive to TME cues for augmented sonodynamic therapy (SDT) and chemodynamic therapy (CDT), eliciting a strong immune response.
Article
Chemistry, Multidisciplinary
Yinmin Zhao, Jiahui Liu, Mengting He, Qi Dong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The construction of a smart therapeutic nanoplatform consisting of TiO2@Pt/GOx (TPG) allows for efficient sonodynamic therapy (SDT) and starvation therapy (ST), which lead to systemic tumor suppression and hypoxia alleviation in the tumor microenvironment. The optimized energy structure of TPG enables rapid generation of singlet oxygen and hydroxyl radicals. The accumulation of reactive oxygen species and glucose depletion facilitated by TPG result in oxidative damage and energy exhaustion of cancer cells, amplified by Pt-catalyzed oxygen self-supply. The combinatorial therapy also triggers immunogenetic cell death and subsequent suppression of distant tumors and metastasis through antitumor immunity.
Review
Chemistry, Multidisciplinary
Xianbin Ma, Shu-Jin Li, Yuantong Liu, Tian Zhang, Peng Xue, Yuejun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Materials Science, Biomaterials
Lei Zhang, Ruihao Yang, Honglian Yu, Zhigang Xu, Yuejun Kang, Hongjuan Cui, Peng Xue
Summary: This study successfully developed a multifunctional SF-derived nanoplatform combining photodynamic therapy and photothermal therapy, which can effectively inhibit tumor growth and provide useful insights for more medical applications in the future.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Ya Gao, Wei Zhang, Yan Fang Cheng, Yang Cao, Zhigang Xu, Li Qun Xu, Yuejun Kang, Peng Xue
Summary: A PEGDA microneedle patch with surface coating of nanosilver encapsulated gelatin/sucrose film was developed for antibacterial applications, enhancing skin permeation and efficient drug delivery. The rapid release of nanosilver from the microneedles under physiological conditions demonstrated good potential for a broad-spectrum antibacterial effect. Furthermore, the film-coated microneedles exhibited good mechanical strength for skin penetration and showed antibacterial activity against both Gram-positive and Gram-negative bacteria in vitro.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Analytical
Xue Zhao, Yusheng Fu, Chunhui Ren, Jinhong Guo, Yuejun Kang
Summary: An up-conversion luminescent system for the quantitative detection of morphine was developed in this study, utilizing infrared light as an excitation source and up-conversion luminescent material as a label. The system achieved high sensitivity by processing image data with an algorithm and calculating the T/C value, with a detection limit of 0.1 ng mg(-1) and a detection time within 0.5 min.
Article
Nanoscience & Nanotechnology
Yajun Wang, Menghang Zu, Xianbin Ma, Die Jia, Yi Lu, Tian Zhang, Peng Xue, Yuejun Kang, Zhigang Xu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Materials Science, Biomaterials
Zhihao Zhou, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Ruihao Yang, Ruidong Li, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Qian Li, Junjie Ren, Qiubing Chen, Weiwei Liu, Zhigang Xu, Yang Cao, Yuejun Kang, Peng Xue
Article
Materials Science, Biomaterials
Tian Zhang, Xianbin Ma, Shuang Bai, Yajun Wang, Xiaoli Zhang, Yi Lu, Feiqiu Wen, Peng Xue, Yuejun Kang, Zhigang Xu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Xiaodan Jiao, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
