The Functions, Methods, and Mobility of Mitochondrial Transfer Between Cells

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

(2020) Angela C Court et al.   EMBO REPORTS

Miro1 Regulates Neuronal Mitochondrial Transport and Distribution to Alleviate Neuronal Damage in Secondary Brain Injury After Intracerebral Hemorrhage in Rats

(2020) Bing Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1

(2020) Nancy Tseng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

(2020) Sameh Lotfi et al.   Retrovirology

Inter and Intracellular mitochondrial trafficking in health and disease

(2020) Santhanam Shanmughapriya et al.   AGEING RESEARCH REVIEWS

Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke

(2020) Meng Lu et al.   Translational Stroke Research

Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells

(2020) Alexander Tishchenko et al.   Cancers

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

Exosomes in Allergic Airway Diseases

(2019) K. P. Hough et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword

(2019) Cheng Li et al.   BIOSCIENCE REPORTS

Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma

(2019) Lawrence H. Boise et al.   CANCER RESEARCH

Ultrastructure and dynamics of the actin−myosin II cytoskeleton during mitochondrial fission

(2019) Changsong Yang et al.   NATURE CELL BIOLOGY

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer

(2019) Luigi Ippolito et al.   ONCOGENE

Mitochondrial Transfer of Wharton’s Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts

(2019) Tsu-Kung Lin et al.   Oxidative Medicine and Cellular Longevity

Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation

(2019) Francisco Cabrera et al.   BMC BIOTECHNOLOGY

Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer

(2019) Longfei Gao et al.   Frontiers in Cellular Neuroscience

Current progress of mitochondrial transplantation that promotes neuronal regeneration

(2019) Chu-Yuan Chang et al.   Translational Neurodegeneration

Tunneling nanotubes mediate intercellular communication between endothelial progenitor cells and osteoclast precursors

(2019) Rui-Fang Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

(2019) Su Chul Jang et al.   Journal of Extracellular Vesicles

Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content

(2019) Xiaofeng Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic use of extracellular mitochondria in CNS injury and disease

(2019) Yoshihiko Nakamura et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury

(2018) Anne-Marie Rodriguez et al.   CELL CYCLE

Tunneling Nanotubes: A Versatile Target for Cancer Therapy

(2018) Pragyaparamita Sahu et al.   CURRENT CANCER DRUG TARGETS

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution

(2018) Guillermo López‐Doménech et al.   EMBO JOURNAL

RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells

(2018) A. D’Aloia et al.   EXPERIMENTAL CELL RESEARCH

Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses

(2018) Mirosława Panasiuk et al.   JOURNAL OF VIROLOGY

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery

(2018) Valentina Babenko et al.   MOLECULES

Tunneling Nanotubes: Intimate Communication between Myeloid Cells

(2018) Maeva Dupont et al.   Frontiers in Immunology

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells

(2018) Kenneth P. Hough et al.   Redox Biology

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

(2018) Yalda Hekmatshoar et al.   BIOCHEMICAL JOURNAL

Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX

(2018) Stefanie J. Oeding et al.   JOURNAL OF CELL SCIENCE

Rab11a-Rab8a cascade regulate the formation of tunneling nanotubes through vesicle recycling

(2018) Seng Zhu et al.   JOURNAL OF CELL SCIENCE

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation

(2018) Yin Yao et al.   Stem Cell Reports

Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche

(2017) B de Rooij et al.   LEUKEMIA

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Enhancement of Mitochondrial Transfer by Antioxidants in Human Mesenchymal Stem Cells

(2017) Chia-Jung Li et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial function in hypoxic ischemic injury and influence of aging

(2017) P. Benson Ham et al.   PROGRESS IN NEUROBIOLOGY

Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome

(2017) Bhupendra Singh et al.   SEMINARS IN CANCER BIOLOGY

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

(2017) Jinjin Lu et al.   Oncotarget

Intra- and Intercellular Quality Control Mechanisms of Mitochondria

(2017) et al.   Cells

ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain

(2017) Boris I. Shneyer et al.   Scientific Reports

Kinetic adaptation of human Myo19 for active mitochondrial transport to growing filopodia tips

(2017) Marko Ušaj et al.   Scientific Reports

Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread

(2017) George Okafo et al.   Scientific Reports

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

(2016) Dan Jiang et al.   Cell Death & Disease

Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

(2016) Kenneth Andrew Sinclair et al.   Stem Cell Research & Therapy

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy

(2016) Yuelin Zhang et al.   Stem Cell Reports

Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

(2016) Shunsuke Kimura et al.   Scientific Reports

Intercellular transfer of mitochondria

(2015) E. Y. Plotnikov et al.   BIOCHEMISTRY-MOSCOW

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

(2015) J. Paggetti et al.   BLOOD

Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia

(2015) Benedito A Carneiro et al.   CANCER BIOLOGY & THERAPY

Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia

(2015) Boris I. Shneyer et al.   JOURNAL OF CELL SCIENCE

Mitochondrial transfer from Wharton's jelly-derived mesenchymal stem cells to mitochondria-defective cells recaptures impaired mitochondrial function

(2015) Hung-Yu Lin et al.   MITOCHONDRION

Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model

(2015) HUI HAN et al.   Molecular Medicine Reports

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology

(2015) Bor Tang   Cells

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

(2015) Nicol Birsa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial Transfer of Induced Pluripotent Stem Cell–Derived Mesenchymal Stem Cells to Airway Epithelial Cells Attenuates Cigarette Smoke–Induced Damage

(2014) Xiang Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Discovery and implications of transcellular mitophagy

(2014) Chung-ha O. Davis et al.   Autophagy

Myo19 Ensures Symmetric Partitioning of Mitochondria and Coupling of Mitochondrial Segregation to Cell Division

(2014) Jennifer L. Rohn et al.   CURRENT BIOLOGY

Miro1: New wheels for transferring mitochondria

(2014) G. Las et al.   EMBO JOURNAL

Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy

(2014) Tanveer Ahmad et al.   EMBO JOURNAL

Mouse Myosin-19 Is a Plus-end-directed, High-duty Ratio Molecular Motor

(2014) Zekuan Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internalization of isolated functional mitochondria: involvement of macropinocytosis

(2014) Tomoya Kitani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Isolation and Characterization of CD34+ Blast-Derived Exosomes in Acute Myeloid Leukemia

(2014) Chang Sook Hong et al.   PLoS One

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

(2014) Catheleyne D'hondt et al.   Frontiers in Physiology

Tunneling nanotube (TNT) formation is independent of p53 expression

(2013) V Andresen et al.   CELL DEATH AND DIFFERENTIATION

Myo10 is a key regulator of TNT formation in neuronal cells

(2013) K. Gousset et al.   JOURNAL OF CELL SCIENCE

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

(2013) Juan A. Orellana et al.   NEUROPHARMACOLOGY

Genetic basis of cell–cell fusion mechanisms

(2013) Pablo S. Aguilar et al.   TRENDS IN GENETICS

Myosin-Driven Intercellular Transportation of Wheat Germ Agglutinin Mediated by Membrane Nanotubes between Human Lung Cancer Cells

(2012) Zhi-Gang Wang et al.   ACS Nano

The ERMES complex and ER–mitochondria connections

(2012) Agnès H. Michel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation

(2012) C. Schiller et al.   JOURNAL OF CELL SCIENCE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

(2012) E. Taniguchi Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Smooth Muscle Cells Initiate Proliferation of Mesenchymal Stem Cells by Mitochondrial Transfer via Tunneling Nanotubes

(2012) Krishna C. Vallabhaneni et al.   STEM CELLS AND DEVELOPMENT

Exorcising the Exocyst Complex

(2012) Margaret R. Heider et al.   TRAFFIC

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Trafficking Kinesin Protein (TRAK)-mediated Transport of Mitochondria in Axons of Hippocampal Neurons

(2011) Kieran Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer

(2011) Adrien Acquistapace et al.   STEM CELLS

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture

(2010) Egor Y. Plotnikov et al.   EXPERIMENTAL CELL RESEARCH

Evidence That Myosin Activity Opposes Microtubule-Based Axonal Transport of Mitochondria

(2010) D. Pathak et al.   JOURNAL OF NEUROSCIENCE

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

(2009) Elke De Vuyst et al.   CELL CALCIUM

Human Myo19 Is a Novel Myosin that Associates with Mitochondria

(2009) Omar A. Quintero et al.   CURRENT BIOLOGY

The exocyst complex in polarized exocytosis

(2009) Bing He et al.   CURRENT OPINION IN CELL BIOLOGY

Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

(2009) Nickolay V. Bukoreshtliev et al.   FEBS LETTERS

HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport

(2009) Yan Li et al.   JOURNAL OF CELL BIOLOGY

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells☆

(2008) Steffen Gurke et al.   EXPERIMENTAL CELL RESEARCH

Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery

(2008) Anna M. Gumpert et al.   FEBS LETTERS

Mitochondrial Extrusion through the Cytoplasmic Vacuoles during Cell Death

(2008) Akihito Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture

(2008) E. Y. Plotnikov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

(2008) Andrew F. MacAskill et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

(2008) Jens M. Nygren et al.   NATURE CELL BIOLOGY

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY