MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology

Characterization of the three zebrafish orthologs of the mitochondrial GTPase Miro/Rhot

(2016) Brittany M. Hollister et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool

(2016) Kaoru Yasuda et al.   Aging-US

Boymaw, Overexpressed in Brains With Major Psychiatric Disorders, May Encode a Small Protein to Inhibit Mitochondrial Function and Protein Translation

(2015) Baohu Ji et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Mitochondrial quality control pathways as determinants of metabolic health

(2015) Ntsiki M. Held et al.   BIOESSAYS

The impact of mitochondrial endosymbiosis on the evolution of calcium signaling

(2015) Neil W. Blackstone   CELL CALCIUM

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

ER–mitochondria contact sites in yeast: beyond the myths of ERMES

(2015) Alexander Lang et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of mitochondrial transport in neurons

(2015) Mei-Yao Lin et al.   EXPERIMENTAL CELL RESEARCH

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

(2015) Rosalind Norkett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dynamics: Orchestrating the journey to advanced age

(2015) Agnieszka K. Biala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Miro's N-Terminal GTPase Domain Is Required for Transport of Mitochondria into Axons and Dendrites

(2015) M. Babic et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

(2015) Gil Kanfer et al.   Nature Communications

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Miro1 deficiency in amyotrophic lateral sclerosis

(2015) Fan Zhang et al.   Frontiers in Aging Neuroscience

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

(2015) Nicol Birsa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial Transfer of Induced Pluripotent Stem Cell–Derived Mesenchymal Stem Cells to Airway Epithelial Cells Attenuates Cigarette Smoke–Induced Damage

(2014) Xiang Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Mitocentric View of Parkinson's Disease

(2014) Nele A. Haelterman et al.   Annual Review of Neuroscience

Vibrio cholerae T3SS Effector VopE Modulates Mitochondrial Dynamics and Innate Immune Signaling by Targeting Miro GTPases

(2014) Masato Suzuki et al.   Cell Host & Microbe

Molecular mechanism of mitochondrial calcium uptake

(2014) Lele Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Miro1: New wheels for transferring mitochondria

(2014) G. Las et al.   EMBO JOURNAL

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

(2014) Nicol Birsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

(2014) Diego Sepulveda-Falla et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Miro-1 Links Mitochondria and Microtubule Dynein Motors To Control Lymphocyte Migration and Polarity

(2014) G. Morlino et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Toxic Effects of Aβ Through Mitofusins in the Early Pathogenesis of Alzheimer’s Disease

(2014) Zhaofei Wu et al.   MOLECULAR NEUROBIOLOGY

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease

(2014) T. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles

(2014) Celine Akyurekli et al.   Stem Cell Reviews and Reports

Brief Reports: Lysosomal Cross-Correction by Hematopoietic Stem Cell-Derived Macrophages Via Tunneling Nanotubes

(2014) Swati Naphade et al.   STEM CELLS

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond

(2014) Kyu-Sun Lee et al.   Frontiers in Cellular Neuroscience

Eukaryotic Origins: How and When Was the Mitochondrion Acquired?

(2014) A. M. Poole et al.   Cold Spring Harbor Perspectives in Biology

The Armc10/SVH gene: genome context, regulation of mitochondrial dynamics and protection against Aβ-induced mitochondrial fragmentation

(2014) R Serrat et al.   Cell Death & Disease

PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons in Drosophila

(2014) Pei-I Tsai et al.   Scientific Reports

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

(2014) A. Kazlauskaite et al.   Open Biology

Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

(2014) Hector Sandoval et al.   eLife

The mitochondrial Ras-related GTPase Miro: views from inside and outside the metazoan kingdom

(2014) Shohei Yamaoka et al.   Frontiers in Plant Science

In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

(2013) Hiromi Sesaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

(2013) Fumiaki Ogawa et al.   HUMAN MOLECULAR GENETICS

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

Location and membrane sources for autophagosome formation – from ER-mitochondria contact sites to Golgi-endosome-derived carriers

(2013) Shu Ning Chan et al.   MOLECULAR MEMBRANE BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Nanotubular Crosstalk with Distressed Cardiomyocytes Stimulates the Paracrine Repair Function of Mesenchymal Stem Cells

(2013) Florence Figeac et al.   STEM CELLS

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

(2013) Andrew Murley et al.   eLife

Intercellular organelle trafficking by membranous nanotube connections: a possible new role in cellular rejuvenation?

(2012) Yi Shan Lim et al.   CELL COMMUNICATION AND ADHESION

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

(2012) G. M. Morotz et al.   HUMAN MOLECULAR GENETICS

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

(2012) Jennifer E. Eykelenboom et al.   HUMAN MOLECULAR GENETICS

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

Tunneling nanotubes, an emerging intercellular communication route in development

(2012) Hans-Hermann Gerdes et al.   MECHANISMS OF DEVELOPMENT

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance

(2012) Tammy T. Nguyen et al.   TRAFFIC

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2

(2012) Guillermo López-Doménech et al.   Nature Communications

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1

(2012) Kanae Iijima-Ando et al.   PLoS Genetics

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

During hypoxia, HUMMR joins the mitochondrial dance

(2011) Yan Li et al.   CELL CYCLE

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

Arabidopsis thaliana MIRO1 and MIRO2 GTPases Are Unequally Redundant in Pollen Tube Growth and Fusion of Polar Nuclei during Female Gametogenesis

(2011) Christopher G. Sørmo et al.   PLoS One

The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections

(2011) B. Kornmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum

(2010) Georgia Vlahou et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structure-Function Analysis of the Yeast Mitochondrial Rho GTPase, Gem1p

(2010) Takumi Koshiba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons

(2010) T A Atkin et al.   MOLECULAR PSYCHIATRY

MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis

(2010) Shohei Yamaoka et al.   PLANT CELL REPORTS

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport

(2009) Yan Li et al.   JOURNAL OF CELL BIOLOGY

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Multiple Pathways Influence Mitochondrial Inheritance in Budding Yeast

(2008) R. L. Frederick et al.   GENETICS

GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

(2008) Andrew F. MacAskill et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

EMB2473/MIRO1, an Arabidopsis Miro GTPase, Is Required for Embryogenesis and Influences Mitochondrial Morphology in Pollen

(2008) S. Yamaoka et al.   PLANT CELL

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EF-hand domain: A globally cooperative structural unit

(2002) Melanie R. Nelson et al.   PROTEIN SCIENCE