Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells

RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity

(2020) Hee-Jun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bridging the gap: virus long distance spread via tunneling nanotubes

(2020) Robert J.J. Jansens et al.   JOURNAL OF VIROLOGY

Tunneling Nanotubes and Tumor Microtubes in Cancer

(2020) Cora Roehlecke et al.   Cancers

MCF7 Spheroid Development: New Insight about Spatio/Temporal Arrangements of TNTs, Amyloid Fibrils, Cell Connections, and Cellular Bridges

(2020) Laura Pulze et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling

(2019) Sabreen Fostok et al.   Cancers

Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation

(2019) Qurratulain Aftab et al.   Frontiers in Neuroscience

Connexins in cancer: bridging the gap to the clinic

(2019) Trond Aasen et al.   ONCOGENE

Biological Functions of Connexin43 Beyond Intercellular Communication

(2019) Tania Martins-Marques et al.   TRENDS IN CELL BIOLOGY

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

Astrocytes‐derived exosomes induce neuronal recovery after traumatic brain injury via delivering gap junction alpha 1‐20 k

(2019) Wei Chen et al.   Journal of Tissue Engineering and Regenerative Medicine

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

(2019) Nicole Matejka et al.   Radiation Oncology

The connexin 43 C-terminus: A tail of many tales

(2018) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

An update on minding the gap in cancer

(2018) Marc Mesnil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tunneling Nanotubes: A Versatile Target for Cancer Therapy

(2018) Pragyaparamita Sahu et al.   CURRENT CANCER DRUG TARGETS

The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis

(2018) Silvana Valdebenito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

(2018) Trond Aasen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer

(2018) Mélanie Busby et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphorylation of connexin 43 induced by traumatic brain injury promotes exosome release

(2018) Wei Chen et al.   JOURNAL OF NEUROPHYSIOLOGY

Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

(2018) Snider Desir et al.   Scientific Reports

Rab11a-Rab8a cascade regulate the formation of tunneling nanotubes through vesicle recycling

(2018) Seng Zhu et al.   JOURNAL OF CELL SCIENCE

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo

(2018) Maria Kotini et al.   Nature Communications

A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control

(2018) Fatéméh Dubois et al.   Cell Communication and Signaling

Therapeutic strategies targeting connexins

(2018) Dale W. Laird et al.   NATURE REVIEWS DRUG DISCOVERY

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation

(2018) Yin Yao et al.   Stem Cell Reports

Macrophage conditioned medium induced cellular network formation in MCF-7 cells through enhanced tunneling nanotube formation and tunneling nanotube mediated release of viable cytoplasmic fragments

(2017) Pooja Patheja et al.   EXPERIMENTAL CELL RESEARCH

Connexin 43 in the development and progression of breast cancer: What's the connection? (Review)

(2017) Stephanie L. Phillips et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes

(2017) Teresa M. Ribeiro-Rodrigues et al.   JOURNAL OF CELL SCIENCE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Connexins and Disease

(2017) Mario Delmar et al.   Cold Spring Harbor Perspectives in Biology

Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes

(2017) Inés Sáenz-de-Santa-María et al.   Oncotarget

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

(2017) Jennifer Ariazi et al.   Frontiers in Molecular Neuroscience

Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport

(2017) Ying Fu et al.   Frontiers in Physiology

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts

(2017) Kazuo Katoh   PeerJ

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK

(2017) Myriam Jaraíz-Rodríguez et al.   Stem Cell Reports

Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread

(2017) George Okafo et al.   Scientific Reports

Connexin 43, breast cancer tumor suppressor: Missed connections?

(2016) Christina L. Grek et al.   CANCER LETTERS

Communication of Ca2+ signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions

(2016) Jeffrey T. Lock et al.   CELL CALCIUM

Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding

(2016) Tone A. Fykerud et al.   CELL CYCLE

The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes

(2016) Anikó Osteikoetxea-Molnár et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics

(2016) Katrin Martin et al.   Scientific Reports

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration

(2015) Cheng-Hung Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1

(2015) Petra Kameritsch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Senescent cells communicate via intercellular protein transfer

(2015) Anat Biran et al.   GENES & DEVELOPMENT

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

(2015) Seng Zhu et al.   Prion

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Internal translation of the connexin 43 transcript

(2014) Clàudia Salat-Canela et al.   Cell Communication and Signaling

RhoA/rho kinase signaling reduces connexin43 expression in high glucose-treated glomerular mesangial cells with zonula occludens-1 involvement

(2014) Xi Xie et al.   EXPERIMENTAL CELL RESEARCH

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

(2014) Venugopal Thayanithy et al.   EXPERIMENTAL CELL RESEARCH

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain

(2014) Emiko Tatsumi et al.   GLIA

Internal Ribosomal Entry Site (IRES) Activity Generates Endogenous Carboxyl-terminal Domains of Cx43 and Is Responsive to Hypoxic Conditions

(2014) Mahboob Ul-Hussain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes

(2014) Venugopal Thayanithy et al.   Translational Research

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway

(2013) A. Aburima et al.   BLOOD

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion

(2013) Patricia Costa et al.   PLoS One

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

(2013) James W. Smyth et al.   Cell Reports

Gap junction proteins on the move: Connexins, the cytoskeleton and migration

(2012) Linda Matsuuchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells

(2012) Jennifer Pasquier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Targeting Cx43 and N-Cadherin, Which Are Abnormally Upregulated in Venous Leg Ulcers, Influences Migration, Adhesion and Activation of Rho GTPases

(2012) Ariadna Mendoza-Naranjo et al.   PLoS One

RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System

(2012) Raf Ponsaerts et al.   PLoS One

Developing Neurons Form Transient Nanotubes Facilitating Electrical Coupling and Calcium Signaling with Distant Astrocytes

(2012) Xiang Wang et al.   PLoS One

The large GTPase dynamin2: A new player in connexin 43 gap junction endocytosis, recycling and degradation

(2011) Jérôme Gilleron et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Connexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics

(2011) Richard Francis et al.   PLoS One

Laminin-111 Stimulates Proliferation of Mouse Embryonic Stem Cells Through a Reduction of Gap Junctional Intercellular Communication via RhoA-Mediated Cx43 Phosphorylation and Dissociation of Cx43/ZO-1/Drebrin Complex

(2011) Han Na Suh et al.   STEM CELLS AND DEVELOPMENT

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells

(2010) Trond Aasen et al.   Nature Protocols

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

RhoA GTPase and F-actin Dynamically Regulate the Permeability of Cx43-made Channels in Rat Cardiac Myocytes

(2008) Mickaël Derangeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms

(2008) S. J. Coniglio et al.   MOLECULAR AND CELLULAR BIOLOGY