Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

(2020) Zheng Wu et al.   Nature Communications

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells

(2020) Brent Asrican et al.   NEURON

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

(2020) Sara Bottes et al.   NATURE NEUROSCIENCE

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain

(2019) Risa Sueda et al.   GENES & DEVELOPMENT

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

(2019) Hirofumi Noguchi et al.   eLife

Modes of division and differentiation of neural stem cells

(2019) Alexander Lazutkin et al.   BEHAVIOURAL BRAIN RESEARCH

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus

(2019) Runrui Zhang et al.   Cell Reports

Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

(2019) Isabelle Maria Blomfield et al.   eLife

Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus

(2019) Luis E. Gonzalez-Reyes et al.   Scientific Reports

Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest

(2019) Noelia Urbán et al.   NEURON

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

(2018) Yi Zhou et al.   Cell Stem Cell

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

(2018) Anat Shemer et al.   Nature Communications

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

Diazepam Binding Inhibitor Promotes Stem Cell Expansion Controlling Environment-Dependent Neurogenesis

(2017) Ionut Dumitru et al.   NEURON

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Direct neuronal reprogramming: learning from and for development

(2016) Giacomo Masserdotti et al.   DEVELOPMENT

β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells

(2016) Sarah M. Brooker et al.   GLIA

Sall1 is a transcriptional regulator defining microglia identity and function

(2016) Anne Buttgereit et al.   NATURE IMMUNOLOGY

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

(2016) Hedong Li et al.   NEURON

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

Adult Neurogenesis and Psychiatric Disorders

(2016) Eunchai Kang et al.   Cold Spring Harbor Perspectives in Biology

The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

(2016) Rouven Ding et al.   Nature Communications

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

(2016) Amin Khalifeh-Soltani et al.   eLife

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

NG2-glia and their functions in the central nervous system

(2015) L. Dimou et al.   GLIA

A mechanism for the segregation of age in mammalian neural stem cells

(2015) D. L. Moore et al.   SCIENCE

Ontogeny of Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   Frontiers in Immunology

Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus

(2014) Alfonso Lavado et al.   DEVELOPMENTAL BIOLOGY

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

Dissecting Integrin-Dependent Regulation of Neural Stem Cell Proliferation in the Adult Brain

(2014) C. Porcheri et al.   JOURNAL OF NEUROSCIENCE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

(2014) Jimena Andersen et al.   NEURON

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

(2013) D. A. Berg et al.   DEVELOPMENT

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

(2013) Hyeonju Yeo et al.   EMBO JOURNAL

Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia

(2013) Lucio Annunziato et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Wnt7a Regulates Multiple Steps of Neurogenesis

(2013) Q. Qu et al.   MOLECULAR AND CELLULAR BIOLOGY

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/ -catenin-responsive neural stem cells

(2013) A. N. Bowman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

(2013) Ashley E. Webb et al.   Cell Reports

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

The Pessimist's and Optimist's Views of Adult Neurogenesis

(2011) Gerd Kempermann   CELL

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus

(2010) Helena Mira et al.   Cell Stem Cell

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Brain micro-ecologies: neural stem cell niches in the adult mammalian brain

(2007) P. A Riquelme et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES