Direct neuronal reprogramming: learning from and for development

Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

(2016) Jay B. Bikoff et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Stressed out? Healing Tips for Newly Reprogrammed Neurons

(2016) Giorgia Quadrato et al.   Cell Stem Cell

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Pioneer transcription factors, chromatin dynamics, and cell fate control

(2016) Kenneth S Zaret et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cell fate control by pioneer transcription factors

(2016) Makiko Iwafuchi-Doi et al.   DEVELOPMENT

C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

(2016) Bruno Di Stefano et al.   NATURE CELL BIOLOGY

Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

(2016) L. Telley et al.   SCIENCE

Energy metabolism in the acquisition and maintenance of stemness

(2016) Clifford D.L. Folmes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Generating Neuronal Diversity in the Mammalian Cerebral Cortex

(2015) Simona Lodato et al.   Annual Review of Cell and Developmental Biology

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Redox-regulated fate of neural stem progenitor cells

(2015) Tim Prozorovski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells

(2015) VS Fishman et al.   CELL CYCLE

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming

(2015) Gaia Colasante et al.   Cell Stem Cell

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons

(2015) Lei Zhang et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Waddington’s Valleys and Captain Cook’s Islands

(2015) Michael H. Sieweke   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction--differential effects on neurogenesis

(2015) B. Diaz-Castro et al.   EMBO REPORTS

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis

(2015) Magdalena Götz et al.   GLIA

Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

(2015) Athéna R. Ypsilanti et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

The histone chaperone CAF-1 safeguards somatic cell identity

(2015) Sihem Cheloufi et al.   NATURE

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes

(2015) János Fuzik et al.   NATURE BIOTECHNOLOGY

In vivo reprogramming for tissue repair

(2015) Christophe Heinrich et al.   NATURE CELL BIOLOGY

Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain

(2015) J. S. Barbosa et al.   SCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

(2015) Kenichi Toma et al.   Frontiers in Neuroscience

Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development

(2015) Chiaki Ohtaka-Maruyama et al.   Frontiers in Neuroscience

Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis

(2015) Clara-Zoe Wende et al.   PLoS One

Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency

(2014) Julie Mathieu et al.   Cell Stem Cell

Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor

(2014) Yong Jun Kim et al.   Cell Stem Cell

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

(2014) Maria M. Mihaylova et al.   Cell Stem Cell

The role of homeobox genes in retinal development and disease

(2014) Jamie L. Zagozewski et al.   DEVELOPMENTAL BIOLOGY

Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations ofCRX, RAX,OTX2andNEUROD

(2014) Yuko Seko et al.   GENES TO CELLS

Remote control of induced dopaminergic neurons in parkinsonian rats

(2014) Maria Teresa Dell’Anno et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epigenetic Regulator I-BET151 Induces BIM-Dependent Apoptosis and Cell Cycle Arrest of Human Melanoma Cells

(2014) Stuart J. Gallagher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Selective conversion of fibroblasts into peripheral sensory neurons

(2014) Joel W Blanchard et al.   NATURE NEUROSCIENCE

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons

(2014) Simona Lodato et al.   NATURE NEUROSCIENCE

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

(2014) Brian J Wainger et al.   NATURE NEUROSCIENCE

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

Sequential histone-modifying activities determine the robustness of transdifferentiation

(2014) S. Zuryn et al.   SCIENCE

Mitosis Gives a Brief Window of Opportunity for a Change in Gene Transcription

(2014) Richard P. Halley-Stott et al.   PLOS BIOLOGY

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

(2014) Hyong-Ho Cho et al.   PLoS Genetics

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

(2014) Soham Chanda et al.   Stem Cell Reports

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate

(2013) Ronny Stahl et al.   CELL

The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network

(2013) Jovica Ninkovic et al.   Cell Stem Cell

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Mechanisms regulating GABAergic neuron development

(2013) Kaia Achim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development

(2013) Shane V. Hegarty et al.   DEVELOPMENTAL BIOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo

(2013) Caroline Rouaux et al.   NATURE CELL BIOLOGY

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells

(2012) Marisa Karow et al.   Cell Stem Cell

Specification of neural crest into sensory neuron and melanocyte lineages

(2012) William J. Pavan et al.   DEVELOPMENTAL BIOLOGY

Neuronal Classification and Marker Gene Identification via Single-Cell Expression Profiling of Brainstem Vestibular Neurons Subserving Cerebellar Learning

(2012) T. Kodama et al.   JOURNAL OF NEUROSCIENCE

SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

(2012) L. Mu et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors

(2012) F. Inoue et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

A Radial Glia-Specific Role of RhoA in Double Cortex Formation

(2012) Silvia Cappello et al.   NEURON

Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells

(2012) Leslie A. Kirby et al.   PLoS One

Regulation of Terminal Differentiation Programs in the Nervous System

(2011) Oliver Hobert   Annual Review of Cell and Developmental Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

(2011) Jongpil Kim et al.   Cell Stem Cell

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

An Evolved Adeno-associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem Cells

(2011) Jae-Hyung Jang et al.   MOLECULAR THERAPY

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Notch in the Vertebrate Nervous System: An Old Dog with New Tricks

(2011) Tarran Pierfelice et al.   NEURON

Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

(2011) Russell C. Addis et al.   PLoS One

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Metabolic oxidation regulates embryonic stem cell differentiation

(2010) Oscar Yanes et al.   Nature Chemical Biology

FUS mutations in sporadic amyotrophic lateral sclerosis

(2010) Shiao-Lin Lai et al.   NEUROBIOLOGY OF AGING

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Direct Conversion of C. elegans Germ Cells into Specific Neuron Types

(2010) B. Tursun et al.   SCIENCE

Modulation of Fate Determinants Olig2 and Pax6 in Resident Glia Evokes Spiking Neuroblasts in a Model of Mild Brain Ischemia

(2010) Golo Kronenberg et al.   STROKE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

(2010) Alfonso Lavado et al.   PLOS BIOLOGY

Reprogramming cell fates: reconciling rarity with robustness

(2009) Sui Huang   BIOESSAYS

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

Retinoid Signaling and Neurogenin2 Function Are Coupled for the Specification of Spinal Motor Neurons through a Chromatin Modifier CBP

(2009) Seunghee Lee et al.   NEURON

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

(2009) C. A. Lyssiotis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Characterization of the proneural gene regulatory network during mouse telencephalon development

(2008) Julia M Gohlke et al.   BMC BIOLOGY

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum

(2008) P. Arlotta et al.   JOURNAL OF NEUROSCIENCE

The genetics of early telencephalon patterning: some assembly required

(2008) Jean M. Hébert et al.   NATURE REVIEWS NEUROSCIENCE

Insulinoma-Associated 1 Has a Panneurogenic Role and Promotes the Generation and Expansion of Basal Progenitors in the Developing Mouse Neocortex

(2008) Lilla M. Farkas et al.   NEURON

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA