Antiretroviral Drugs Impact Autophagy with Toxic Outcomes

Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function

(2021) Camille Fraichard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reverse transcriptase inhibitors promote the remodeling of nuclear architecture and induce autophagy in prostate cancer cells

(2020) Cristina Bellisai et al.   CANCER LETTERS

Pregnancy and neonatal outcomes in women with HIV-1 exposed to integrase inhibitors, protease inhibitors and non-nucleoside reverse transcriptase inhibitors: an observational study

(2020) Marco Floridia et al.   INFECTION

Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort

(2020) Phillip Chan et al.   AIDS Research and Therapy

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

(2020) Changfeng Li et al.   Autophagy

Placental growth disorders and perinatal adverse outcomes in Brazilian HIV-infected pregnant women

(2020) Helena Lucia Barroso dos Reis et al.   PLoS One

Pregnancy Outcomes of Women Conceiving on Antiretroviral Therapy (ART) Compared to Those Commenced on ART During Pregnancy

(2020) Gerhard Theron et al.   CLINICAL INFECTIOUS DISEASES

HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

(2020) Laura Cheney et al.   Cells

N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction

(2020) Ashutosh Tripathi et al.   Frontiers in Neurology

Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology

(2020) Michael Yampolsky et al.   PLACENTA

Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes

(2019) Myosotys Rodriguez et al.   JOURNAL OF NEUROVIROLOGY

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack

(2019) Olga Martinez-Arroyo et al.   ANTIVIRAL RESEARCH

Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction

(2019) Ashutosh Tripathi et al.   Cells

Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy

(2019) Francesca La Rosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients

(2018) Amandine Serrano et al.   AIDS

Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

(2018) Ana Santos-Llamas et al.   ARCHIVES OF TOXICOLOGY

Use of antiretroviral therapy during pregnancy and adverse birth outcomes among women living with HIV-1 in low and middle-income countries

(2018) Jessica Londeree Saleska et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Preconception use of cART by HIV-positive pregnant women increases the risk of infants being born small for gestational age

(2018) Ingrid J. M. Snijdewind et al.   PLoS One

HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

(2018) Hakimeh Mohammadi et al.   Scientific Reports

Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma

(2018) Weiwen Liu et al.   Journal of Cancer

Modulating cellular autophagy for controlled antiretroviral drug release

(2018) Midhun B Thomas et al.   Nanomedicine

Long-Acting HIV Drugs for Treatment and Prevention

(2018) Roy M. Gulick et al.   Annual Review of Medicine

Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells

(2018) H. Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

(2018) Davide De Francesco et al.   AIDS

Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology

(2017) Elif Guzel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Psychiatric Symptoms in Patients Receiving Dolutegravir

(2017) Anna Fettiplace et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

(2017) Divya Prakash Gnanadhas et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleoside reverse transcriptase inhibitor-induced rat oocyte dysfunction and low fertility mediated by autophagy

(2017) Li Tang et al.   Oncotarget

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Exposure to zidovudine adversely affects mitochondrial turnover in primary T cells

(2016) Zoë R. Wallace et al.   ANTIVIRAL RESEARCH

Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs

(2016) Ina Patties et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Effects of Combined Alcohol and Anti-HIV Drugs on Cellular Stress Responses in Primary Hepatocytes and Hepatic Stellate and Kupffer Cells

(2015) Jay Hu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage

(2015) Ana B. Sanchez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells

(2015) Marlene Weiß et al.   Cardiovascular Toxicology

Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations

(2015) Eric H. Decloedt et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetics and Pharmacodynamics of Antiretrovirals in the Central Nervous System

(2014) Andrea Calcagno et al.   CLINICAL PHARMACOKINETICS

Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz

(2014) A. Blas-Garcia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The HIV Protease Inhibitor Nelfinavir Down-Regulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells

(2014) Yevgeniya Kushchayeva et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine

(2014) Charlotte E. Johnson et al.   Molecular Oncology

Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes

(2014) Monika Bociąga-Jasik et al.   Pharmacological Reports

Analysis of endoplasmic reticulum stress in placentas of HIV-infected women treated with protease inhibitors

(2014) Ansgar Brüning et al.   REPRODUCTIVE TOXICOLOGY

Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes

(2013) QINGHUA DONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

(2013) Beth S. Zha et al.   PLoS One

Nucleoside Reverse Transcriptase Inhibitors Induce a Mitophagy-Associated Endothelial Cytotoxicity That Is Reversed by Coenzyme Q10 Cotreatment

(2013) Stephen Y. Xue et al.   TOXICOLOGICAL SCIENCES

Where does HIV hide? A focus on the central nervous system

(2013) Melissa Churchill et al.   Current Opinion in HIV and AIDS

The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes

(2012) Lara Gibellini et al.   AIDS

Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation

(2012) Metodi V. Stankov et al.   AIDS

Thymidine Analogues Suppress Autophagy and Adipogenesis in Cultured Adipocytes

(2012) Metodi V. Stankov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Low Cerebrospinal Fluid Concentrations of the Nucleotide HIV Reverse Transcriptase Inhibitor, Tenofovir

(2012) Brookie M. Best et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV and Aging

(2012) Kevin P. High et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population

(2011) G. Guaraldi et al.   CLINICAL INFECTIOUS DISEASES

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy

(2011) Nadezda Apostolova et al.   HEPATOLOGY

Safety and exposure of once-daily ritonavir-boosted atazanavir in HIV-infected pregnant women

(2011) F Conradie et al.   HIV MEDICINE

Antiretroviral drug treatment of CNS HIV-1 infection

(2011) A. Yilmaz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nucleoside Analog Stavudine Depletes Mitochondrial DNA with No Organelle Loss in Mouse Oocytes

(2010) Alionka Bostan et al.   CURRENT HIV RESEARCH

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

(2010) D. F. Carr et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

(2010) B. M. Best et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Atazanavir

(2009) Katherine F. Croom et al.   DRUGS