N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction
Authors
Keywords
-
Journal
Frontiers in Neurology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-09-04
DOI
10.3389/fneur.2020.00840
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Antiretroviral Drugs Promote Amyloidogenesis by De-Acidifying Endolysosomes
- (2019) Liang Hui et al. Journal of Neuroimmune Pharmacology
- Co-formulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial
- (2019) Hans-Jürgen Stellbrink et al. Lancet HIV
- Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction
- (2019) Ashutosh Tripathi et al. Cells
- Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes, and microglia
- (2019) Sulay H. Patel et al. NEUROSCIENCE LETTERS
- Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy
- (2018) Leah H. Rubin et al. AIDS
- Role of Autophagy in Parkinson’s Disease
- (2018) Silvia Cerri et al. CURRENT MEDICINAL CHEMISTRY
- Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
- (2018) Daniel J. Colacurcio et al. FREE RADICAL BIOLOGY AND MEDICINE
- The pathogenesis of lysosomal storage disorders: beyond the engorgement of lysosomes to abnormal development and neuroinflammation
- (2018) Maria Teresa Fiorenza et al. HUMAN MOLECULAR GENETICS
- Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
- (2018) Carmen Mecca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine
- (2018) Steven D. Weisbord et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
- (2018) Xian-Si Zeng et al. Frontiers in Aging Neuroscience
- Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults
- (2018) Michael S. Saag et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound
- (2018) Afam A. Okoye et al. NATURE MEDICINE
- Lysosomal membrane permeabilization and cell death
- (2018) Fengjuan Wang et al. TRAFFIC
- An Overview of in vitro Methods to Study Microglia
- (2018) Raissa Timmerman et al. Frontiers in Cellular Neuroscience
- Efficacy and safety of switching to dolutegravir plus emtricitabine/tenofovir disoproxil fumarate (TDF) or elvitegravir/cobicistat/emtricitabine/TDF in virologically suppressed HIV-infected patients in clinical practice: results from a multicentre, observ
- (2018) G Baldin et al. HIV MEDICINE
- Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials
- (2018) Pedro Cahn et al. LANCET
- Treatment with a fixed dose combination antiretroviral therapy drug containing tenofovir, emtricitabine and efavirenz is associated with cardioprotection in high calorie diet-induced obese rats
- (2018) Frans Everson et al. PLoS One
- A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration
- (2018) Meng-meng Jin et al. Frontiers in Aging Neuroscience
- Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration
- (2017) Doris Lam et al. Journal of Neuroinflammation
- HIV-Associated Neurocognitive Disorders: A Global Perspective
- (2017) Rowan Saloner et al. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
- (2017) Christopher J. Bohlen et al. NEURON
- Implication of Different HIV-1 Genes in the Modulation of Autophagy
- (2017) Zhenlong Liu et al. Viruses-Basel
- Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle
- (2017) Olivier Leymarie et al. Viruses-Basel
- HIV-associated synaptic degeneration
- (2017) Wenjuan Ru et al. Molecular Brain
- Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress
- (2017) Raquel Pascua-Maestro et al. PLoS Genetics
- Neurological Complications of HIV Infection
- (2017) Shelli Farhadian et al. Current Infectious Disease Reports
- Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques
- (2016) Gregory Q. Del Prete et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- p62 in Cancer: Signaling Adaptor Beyond Autophagy
- (2016) Jorge Moscat et al. CELL
- Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
- (2016) Zhenyu Zhong et al. CELL
- HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment
- (2016) Deanna Saylor et al. Nature Reviews Neurology
- Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
- (2016) Tarique Hussain et al. Oxidative Medicine and Cellular Longevity
- High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial
- (2016) Dennis Niewoehner et al. International Journal of Chronic Obstructive Pulmonary Disease
- Biological and physiological role of reactive oxygen species - the good, the bad and the ugly
- (2015) L. Zuo et al. Acta Physiologica
- Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay
- (2015) Sonja Aits et al. Autophagy
- The HIV-1 transgenic rat model of neuroHIV
- (2015) Michael Vigorito et al. BRAIN BEHAVIOR AND IMMUNITY
- Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy
- (2015) Wei Jing Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antiretrovirals inhibit arginase in human microglia
- (2015) Lucia Lisi et al. JOURNAL OF NEUROCHEMISTRY
- Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
- (2015) Deepmala et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Neuroinflammatory paradigms in lysosomal storage diseases
- (2015) Megan E. Bosch et al. Frontiers in Neuroscience
- To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate
- (2014) Douglas R. Green et al. CELL
- Pharmacokinetics and Pharmacodynamics of Antiretrovirals in the Central Nervous System
- (2014) Andrea Calcagno et al. CLINICAL PHARMACOKINETICS
- Oxidative Stress in HIV Patients Receiving Antiretroviral Therapy
- (2014) Bechan Sharma CURRENT HIV RESEARCH
- Brain Inflammation is a Common Feature of HIV-Infected Patients without HIV Encephalitis or Productive Brain Infection
- (2014) Eleonora Tavazzi et al. CURRENT HIV RESEARCH
- Eradication of human immunodeficiency virus from brain reservoirs
- (2014) Avindra Nath JOURNAL OF NEUROVIROLOGY
- Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
- (2014) Cagla Akay et al. JOURNAL OF NEUROVIROLOGY
- N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
- (2014) Reza Bavarsad Shahripour et al. Brain and Behavior
- Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART
- (2013) Lucy J. Garvey et al. AIDS
- Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy
- (2013) Jae Myung Park et al. CANCER BIOLOGY & THERAPY
- ER stress in human hepatic cells treated with Efavirenz: Mitochondria again
- (2013) Nadezda Apostolova et al. JOURNAL OF HEPATOLOGY
- Antiretroviral agents increase NO production in gp120/IFNγ-stimulated cultures of rat microglia via an arginase-dependent mechanism
- (2013) Lucia Lisi et al. JOURNAL OF NEUROIMMUNOLOGY
- HIV-associated neurocognitive disorder
- (2013) David B Clifford et al. LANCET INFECTIOUS DISEASES
- Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment
- (2013) F.M. Bollmann MEDICAL HYPOTHESES
- Lysosome Dysfunction Enhances Oxidative Stress-Induced Apoptosis through Ubiquitinated Protein Accumulation in Hela Cells
- (2012) Chunyan Yu et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Role of Endolysosomes in HIV-1 Tat-Induced Neurotoxicity
- (2012) Liang Hui et al. ASN Neuro
- Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
- (2012) Frances M. Platt et al. JOURNAL OF CELL BIOLOGY
- Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat
- (2012) Walter Royal et al. JOURNAL OF NEUROIMMUNOLOGY
- Cysteine cathepsins: From structure, function and regulation to new frontiers
- (2011) Vito Turk et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography
- (2011) CIRCULATION
- Regulation of Innate Immune Responses in the Central Nervous System
- (2011) Jeffrey J. Bajramovic CNS & Neurological Disorders-Drug Targets
- Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy
- (2011) Nadezda Apostolova et al. HEPATOLOGY
- Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis
- (2011) Dejiang Zhou et al. JOURNAL OF INFECTIOUS DISEASES
- Strategies for Reducing or Preventing the Generation of Oxidative Stress
- (2011) B. Poljsak Oxidative Medicine and Cellular Longevity
- HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: Potential role of the thiol antioxidant N-acetylcysteine amide
- (2010) Atrayee Banerjee et al. FREE RADICAL BIOLOGY AND MEDICINE
- Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells
- (2010) Kalyan Reddy Manda et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells
- (2010) Ana Blas-García et al. HEPATOLOGY
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy
- (2009) Antonella Mandas et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART
- (2009) Jinsong Peng et al. JOURNAL OF NEUROIMMUNOLOGY
- Why Have Antioxidants Failed in Clinical Trials?
- (2008) Steven R. Steinhubl AMERICAN JOURNAL OF CARDIOLOGY
- The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
- (2008) T. Pan et al. BRAIN
- Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration
- (2008) Mehrdad Alirezaei et al. PLoS One
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started