Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice

GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn

(2020) Norikazu Kiguchi et al.   NEUROPHARMACOLOGY

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation

(2020) Dezun Ma et al.   BIOMATERIALS

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

(2020) William Binning et al.   BRAIN BEHAVIOR AND IMMUNITY

Qualitative sex differences in pain processing: emerging evidence of a biased literature

(2020) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

(2020) Fumihiro Saika et al.   Frontiers in Pharmacology

Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain

(2020) Christopher R. Donnelly et al.   Neurotherapeutics

Astrocytes in chronic pain and itch

(2019) Ru-Rong Ji et al.   NATURE REVIEWS NEUROSCIENCE

Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation

(2018) Jee Youn Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice

(2018) Abdullah Al Mamun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

(2018) Peter M. Grace et al.   EXPERIMENTAL NEUROLOGY

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine

(2018) Ewelina Rojewska et al.   Frontiers in Immunology

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Transcriptional and Translational Differences of Microglia from Male and Female Brains

(2018) Dilansu Guneykaya et al.   Cell Reports

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence

(2016) T. Berta et al.   JOURNAL OF DENTAL RESEARCH

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Minocycline enhances inhibitory transmission to substantia gelatinosa neurons of the rat spinal dorsal horn

(2016) H.-Z. Peng et al.   NEUROSCIENCE

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

The Use of DREADDs to Deconstruct Behavior

(2016) Paul D. Whissell et al.   Frontiers in Genetics

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Ovarian hormones and chronic pain: A comprehensive review

(2014) Samah Hassan et al.   PAIN

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Animal models of neuropathic pain

(2010) Amteshwar Singh Jaggi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain

(2010) Norikazu Kiguchi et al.   NEUROSCIENCE LETTERS

Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease

(2009) Sharmila Patel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Ablation of estrogen receptor α or β eliminates sex differences in mechanical pain threshold in normal and inflamed mice

(2009) Lili Li et al.   PAIN

Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia

(2008) Radmila Filipovic et al.   EXPERIMENTAL NEUROLOGY

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat

(2008) Young Seob Gwak et al.   PAIN

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN