Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Activity-triggered tetrapartite neuron–glial interactions following peripheral injury

(2016) Ke Ren et al.   CURRENT OPINION IN PHARMACOLOGY

How sex and age affect immune responses, susceptibility to infections, and response to vaccination

(2015) Carmen Giefing-Kröll et al.   AGING CELL

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

(2015) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Prevalence of pain in the orofacial regions in patients visiting general dentists in the Northwest Practice-based REsearch Collaborative in Evidence-based DENTistry research network

(2015) Orapin V. Horst et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Sex differences and stress across the lifespan

(2015) Tracy L Bale et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Dysregulated TNFα promotes cytokine proteome profile increases and bilateral orofacial hypersensitivity

(2015) F. Ma et al.   NEUROSCIENCE

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Predicting Severe Pain after Root Canal Therapy in the National Dental PBRN

(2014) A.S. Law et al.   JOURNAL OF DENTAL RESEARCH

The human side of microglia

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

Caspase-6 as a novel early target in the treatment of Alzheimer's disease

(2013) Andrea C. LeBlanc   EUROPEAN JOURNAL OF NEUROSCIENCE

P2X7 Receptor and Cytokines Contribute to Extra-territorial Facial Pain

(2013) K. Murasaki et al.   JOURNAL OF DENTAL RESEARCH

Fractalkine Signaling in Microglia Contributes to Ectopic Orofacial Pain following Trapezius Muscle Inflammation

(2013) M. Kiyomoto et al.   JOURNAL OF NEUROSCIENCE

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Summary of Findings From the OPPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorder: Implications and Future Directions

(2013) Gary D. Slade et al.   JOURNAL OF PAIN

General Health Status and Incidence of First-Onset Temporomandibular Disorder: The OPPERA Prospective Cohort Study

(2013) Anne E. Sanders et al.   JOURNAL OF PAIN

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Role of Astrocytes in Pain

(2012) C.-Y. Chiang et al.   NEUROCHEMICAL RESEARCH

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages

(2011) Russell P. Landry et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Cryotherapy and Topical Minocycline as Adjunctive Measures to Control Pain After Third Molar Surgery: An Exploratory Study

(2011) Savannah Gelesko et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Role of Glia in Orofacial Pain

(2011) Chen-Yu Chiang et al.   NEUROSCIENTIST

Caspase-6 and neurodegeneration

(2011) Rona K. Graham et al.   TRENDS IN NEUROSCIENCES

Involvement of microglial activation in the brainstem in experimental dental injury and inflammation

(2010) Wenguo Fan et al.   ARCHIVES OF ORAL BIOLOGY

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study

(2009) Jarred Younger et al.   PAIN MEDICINE

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury

(2008) K. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of Mechanical and Thermal Nociceptive Sensitivity in the Laboratory Mouse by Behavioral State

(2007) Brandy L. Callahan et al.   JOURNAL OF PAIN