Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors

Testicular Stem Cell Dysfunction Due to Environmental Insults Could Be Responsible for Deteriorating Reproductive Health of Men

(2021) Deepa Bhartiya et al.   Reproductive Sciences

Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest

(2021) João Lobo et al.   Pharmaceutics

Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors

(2021) João Lobo et al.   Molecular Oncology

Testicular Germ Cell Tumors Acquire Cisplatin Resistance by Rebalancing the Usage of DNA Repair Pathways

(2021) Cinzia Caggiano et al.   Cancers

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

(2020) Zuzana Cierna et al.   BMC CANCER

Epigenetic alterations of testicular germ cell tumours

(2020) Dafina Ilijazi et al.   CURRENT OPINION IN UROLOGY

DNA damage response and resistance of cancer stem cells

(2020) Etna Abad et al.   CANCER LETTERS

Resolving DNA Damage: Epigenetic Regulation of DNA Repair

(2020) Panagiotis Karakaidos et al.   MOLECULES

Genomic landscape of platinum resistant and sensitive testicular cancers

(2020) Chey Loveday et al.   Nature Communications

Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer

(2020) Manuel Regouc et al.   Cancers

Estimates of over-time trends in incidence and mortality of testicular cancer from 1990 to 2030

(2020) Qiliang Cai et al.   Translational Andrology and Urology

Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours : current and future application of ‘epidrugs’

(2020) Ana Rita Cardoso et al.   Epigenetics

Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives

(2020) João Lobo et al.   Cancers

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

(2020) Yasutaka Sakurai et al.   CANCER LETTERS

Hypermethylation and global remodeling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumors

(2020) Zeeshan Fazal et al.   Epigenetics

Effects of testicular dysgenesis syndrome components on testicular germ cell tumor prognosis and oncological outcomes

(2020) Ismail Selvi et al.   International Braz J Urol

Differential expression of DNA methyltransferases and demethylases among the various testicular germ cell tumor subtypes

(2020) João Lobo et al.   Epigenomics

Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors

(2020) João Lobo et al.   Cancers

Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors

(2020) Lucia Nappi et al.   EUROPEAN UROLOGY

Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

(2019) João Lobo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic treatment combinations to effectively target cisplatin‐resistant germ cell tumors‐past, present, and future considerations

(2019) C. Oing et al.   Andrology

New insights into germ cell tumor genomics

(2019) J.T. Lafin et al.   Andrology

Clonal analyses of refractory testicular germ cell tumors

(2019) Michael T. Barrett et al.   PLoS One

Epigenetic drugs and their molecular targets in testicular germ cell tumours

(2019) Sina Jostes et al.   Nature Reviews Urology

Factors that impact the outcomes in testicular germ cell tumors in low–middle-income countries

(2019) S. V. Saju et al.   MEDICAL ONCOLOGY

Current pharmacotherapy for testicular germ cell cancer

(2019) Winfried Alsdorf et al.   EXPERT OPINION ON PHARMACOTHERAPY

Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo

(2019) Dongyuan Wang et al.   CANCER RESEARCH

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

(2019) Lambert C. J. Dorssers et al.   BRITISH JOURNAL OF CANCER

Genetics of testicular germ cell tumors

(2019) Nirmish Singla et al.   CURRENT OPINION IN UROLOGY

MicroRNAs as Biomarkers for Germ Cell Tumors

(2019) Lucia Nappi et al.   UROLOGIC CLINICS OF NORTH AMERICA

Postchemotherapy Resection of Residual Mass in Nonseminomatous Germ Cell Tumor

(2019) Saum Ghodoussipour et al.   UROLOGIC CLINICS OF NORTH AMERICA

Germline genome protection: implications for gamete quality and germ cell tumorigenesis

(2019) J. C. Bloom et al.   Andrology

miRNA-302s may act as oncogenes in human testicular germ cell tumours

(2019) Mrinal K. Das et al.   Scientific Reports

On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer

(2019) Tiziano Baroni et al.   Frontiers in Endocrinology

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

(2019) Ratnakar Singh et al.   Cancers

Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

(2019) Jin-Hong Kim   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality

(2019) Lobo et al.   Cancers

Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology

(2019) Leendert H. J. Looijenga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammalian germ cells are determined after PGC colonization of the nascent gonad

(2019) Peter K. Nicholls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

(2018) Ildar V. Gainetdinov et al.   BMC CANCER

Molecular mechanisms of resistance in testicular germ cell tumors – Clinical implications

(2018) Katarina Kalavska et al.   CURRENT CANCER DRUG TARGETS

Epigenome regulation during germ cell specification and development from pluripotent stem cells

(2018) Kazuki Kurimoto et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Update on epidemiologic considerations and treatment trends in testicular cancer

(2018) Solomon L. Woldu et al.   CURRENT OPINION IN UROLOGY

Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene

(2018) Kevin Litchfield et al.   EUROPEAN UROLOGY

Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology

(2018) Chey Loveday et al.   EUROPEAN UROLOGY

Epigenetics and testicular germ cell tumors

(2018) Robert Buljubašić et al.   GENE

Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder?

(2018) Jian-Sheng Xing et al.   LIFE SCIENCES

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

Bivalent Histone Modifications and Development

(2018) Feifei Li et al.   Current Stem Cell Research & Therapy

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular Mechanisms of Cisplatin Chemoresistance and Its Circumventing in Testicular Germ Cell Tumors

(2018) Silvia Schmidtova et al.   Current Oncology Reports

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

(2018) Christoph Oing et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors

(2018) Daniel Nettersheim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Emerging Role of Epitranscriptomics in Cancer: Focus on Urological Tumors

(2018) João Lobo et al.   Genes

The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors

(2018) João Lobo et al.   Cancers

Can germ cell neoplasia in situ be diagnosed by measuring serum levels of microRNA371a-3p?

(2017) A. Radtke et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy

(2017) Chunkit Fung et al.   JOURNAL OF CLINICAL ONCOLOGY

Animacroxam, a Novel Dual-Mode Compound Targeting Histone Deacetylases and Cytoskeletal Integrity of Testicular Germ Cell Cancer Cells

(2017) Gustav Steinemann et al.   MOLECULAR CANCER THERAPEUTICS

Histone methylation and the DNA damage response

(2017) Fade Gong et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

(2017) Zhaoming Wang et al.   NATURE GENETICS

Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity

(2017) Samuel G. Awuah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testicular cancer from diagnosis to epigenetic factors

(2017) Mariarosaria Boccellino et al.   Oncotarget

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer

(2017) Timothy M. Pierpont et al.   Cell Reports

The biology of germ cell tumors in disorders of sex development

(2016) Remko Hersmus et al.   CLINICAL GENETICS

Subfertility increases risk of testicular cancer: evidence from population-based semen samples

(2016) Heidi A. Hanson et al.   FERTILITY AND STERILITY

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors

(2016) J. Keith Killian et al.   GENOME RESEARCH

Germ cell neoplasiain situ(GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

(2016) Daniel M Berney et al.   HISTOPATHOLOGY

The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel

(2016) Sean R Williamson et al.   HISTOPATHOLOGY

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

(2016) Sina Jostes et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

(2016) Aditya Bagrodia et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic evolution and chemoresistance in germ-cell tumours

(2016) Amaro Taylor-Weiner et al.   NATURE

An essential role for UTX in resolution and activation of bivalent promoters

(2016) Shilpa S. Dhar et al.   NUCLEIC ACIDS RESEARCH

Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility

(2016) Niels E. Skakkebaek et al.   PHYSIOLOGICAL REVIEWS

Intratumoral heterogeneity and chemoresistance in nonseminomatous germ cell tumor of the testis

(2016) Mehmet Asim Bilen et al.   Oncotarget

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

(2016) Daniel Nettersheim et al.   Oncotarget

MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients

(2016) Camila Maria da Silva Martinelli et al.   Oncotarget

SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate

(2016) Daniel Nettersheim et al.   Oncotarget

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

(2016) Costantine Albany et al.   Oncotarget

Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship

(2015) Jesper F. Christensen et al.   ACTA ONCOLOGICA

Rare inactivatingPDE11Avariants associated with testicular germ cell tumors

(2015) Anand Pathak et al.   ENDOCRINE-RELATED CANCER

Diagnostic markers for germ cell neoplasms: from placental-like alkaline phosphatase to micro-RNAs

(2015) Ewa Rajpert-De Meyts et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Secondary malignant neoplasms in testicular cancer survivors

(2015) Stephanie A. Curreri et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Identification of four new susceptibility loci for testicular germ cell tumour

(2015) Kevin Litchfield et al.   Nature Communications

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

(2015) Kevin Litchfield et al.   Nature Communications

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors

(2015) Martin A. Rijlaarsdam et al.   PLoS One

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for pre-invasive diagnosis

(2014) JennyE Elzinga-Tinke et al.   ASIAN JOURNAL OF ANDROLOGY

Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives

(2014) P Wongtrakoongate et al.   BRITISH JOURNAL OF CANCER

Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25

(2014) K. Litchfield et al.   HUMAN MOLECULAR GENETICS

A miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor

(2014) Bi-Feng Chen et al.   Scientific Reports

Association between ERCC1 and XPA expression and polymorphisms and the response to cisplatin in testicular germ cell tumours

(2013) J Mendoza et al.   BRITISH JOURNAL OF CANCER

LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels

(2013) M. J. Murray et al.   CANCER RESEARCH

Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4

(2013) M. Gutekunst et al.   CANCER RESEARCH

Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis

(2013) Humberto J Ferreira et al.   Epigenetics

Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23

(2013) F. R. Schumacher et al.   HUMAN MOLECULAR GENETICS

Congenital malformations and testicular germ cell tumors

(2013) Britton Trabert et al.   INTERNATIONAL JOURNAL OF CANCER

Development of malignant germ cells - the genvironmental hypothesis

(2013) Leendert H. J. Looijenga et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

(2013) Elise Ruark et al.   NATURE GENETICS

Meta-analysis identifies four new loci associated with testicular germ cell tumor

(2013) Charles C Chung et al.   NATURE GENETICS

Chemotherapeutic Sensitivity of Testicular Germ Cell Tumors Under Hypoxic Conditions Is Negatively Regulated by SENP1-Controlled Sumoylation of OCT4

(2012) Y.-C. Wu et al.   CANCER RESEARCH

Age at puberty and risk of testicular cancer: a meta-analysis

(2012) M. Maule et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Adolescent and adult risk factors for testicular cancer

(2012) Katherine A. McGlynn et al.   Nature Reviews Urology

Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation

(2012) Bijesh K. Biswal et al.   PLoS One

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

(2012) Francesca Cavallo et al.   PLoS One

Progression-free and overall survival in patients with relapsed/refractory germ cell tumors treated with single-agent chemotherapy: Endpoints for clinical trial design

(2011) Darren R. Feldman et al.   CANCER

Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

(2011) J. Wang et al.   CANCER RESEARCH

The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression

(2011) Daniel Nettersheim et al.   GENES CHROMOSOMES & CANCER

A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

(2011) Peter A. Kanetsky et al.   HUMAN MOLECULAR GENETICS

Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors

(2011) Patrik Romerius et al.   Pharmacogenetics and Genomics

p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin

(2011) Matthias Gutekunst et al.   PLoS One

Familial testicular germ cell tumours

(2010) Christian P. Kratz et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Histological evidence for the existence of germ cell tumor cells showing embryonal carcinoma morphology but lacking OCT4 expression and cisplatin sensitivity

(2010) Thomas Mueller et al.   HISTOCHEMISTRY AND CELL BIOLOGY

CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility

(2010) W. Kristiansen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer—experiences of the son

(2010) Michael B Cook et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

(2010) Roelof Koster et al.   JOURNAL OF CLINICAL INVESTIGATION

Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance

(2010) Hendrik Wermann et al.   JOURNAL OF PATHOLOGY

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression

(2010) Svetlana Usanova et al.   Molecular Cancer

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer

(2010) Clare Turnbull et al.   NATURE GENETICS

High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors

(2009) M. J. Beyrouthy et al.   CANCER RESEARCH

A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer—experiences of the mother

(2009) Michael B Cook et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Microsatellite Instability, Mismatch Repair Deficiency, andBRAFMutation in Treatment-Resistant Germ Cell Tumors

(2009) Friedemann Honecker et al.   JOURNAL OF CLINICAL ONCOLOGY

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer

(2009) Peter A Kanetsky et al.   NATURE GENETICS

A genome-wide association study of testicular germ cell tumor

(2009) Elizabeth A Rapley et al.   NATURE GENETICS

Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors

(2008) Jonine D. Figueroa et al.   CANCER CAUSES & CONTROL