Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours : current and future application of ‘epidrugs’
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Title
Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours : current and future application of ‘epidrugs’
Authors
Keywords
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Journal
Epigenetics
Volume -, Issue -, Pages 1-20
Publisher
Informa UK Limited
Online
2020-08-04
DOI
10.1080/15592294.2020.1805682
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Note: Only part of the references are listed.- Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia
- (2020) Konstantinos Tzelepis et al. BLOOD
- Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
- (2020) Zuzana Cierna et al. BMC CANCER
- Targeting the Immune system and Epigenetic Landscape of Urological Tumors
- (2020) João Lobo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Writers, readers and erasers of RNA modifications in cancer
- (2020) Rosaura Esteve-Puig et al. CANCER LETTERS
- Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours
- (2020) Kristian Almstrup et al. Nature Reviews Urology
- Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2
- (2020) Namrata Bora-Singhal et al. Scientific Reports
- Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?
- (2020) Filipa Moreira-Silva et al. Pharmaceutics
- Proteolysis targeting chimeras (PROTACs) for epigenetics research
- (2020) Anja Vogelmann et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic
- (2019) João Lobo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cytosine-Based TET Enzyme Inhibitors
- (2019) Gabriella N. L. Chua et al. ACS Medicinal Chemistry Letters
- m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance
- (2019) João Lobo et al. Journal of Translational Medicine
- Phase II study of avelumab in multiple relapsed/refractory germ cell cancer
- (2019) M. Mego et al. INVESTIGATIONAL NEW DRUGS
- MicroRNA Dysregulation in Malignant Germ Cell Tumors: More Than a Biomarker?
- (2019) Matthew J. Murray et al. JOURNAL OF CLINICAL ONCOLOGY
- Noncoding RNAs in cancer therapy resistance and targeted drug development
- (2019) Wen-Tao Wang et al. Journal of Hematology & Oncology
- Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
- (2019) Hao Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- miRNA-302s may act as oncogenes in human testicular germ cell tumours
- (2019) Mrinal K. Das et al. Scientific Reports
- Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum
- (2019) Lucia Nappi et al. JOURNAL OF CLINICAL ONCOLOGY
- XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality
- (2019) Lobo et al. Cancers
- Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study
- (2019) Thomas Wagner et al. BMJ Open
- Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers
- (2019) João Lobo et al. Cancers
- Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data
- (2019) João Lobo et al. Cells
- New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells
- (2018) Nam Hoang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Epigenetics and testicular germ cell tumors
- (2018) Robert Buljubašić et al. GENE
- EP-1618: Monoubiquitinylated histone H2B as a potential target in treatment resistant germ cell tumors
- (2018) C. Oing et al. RADIOTHERAPY AND ONCOLOGY
- Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
- (2018) Jay H. Kalin et al. Nature Communications
- Integrated Molecular Characterization of Testicular Germ Cell Tumors
- (2018) Hui Shen et al. Cell Reports
- Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation
- (2018) Zheng Peng et al. MEDICAL SCIENCE MONITOR
- Targeting DNA Methyltranferases in Urological Tumors
- (2018) Ângela Marques-Magalhães et al. Frontiers in Pharmacology
- Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
- (2018) Zuni I. Bassi et al. ACS Chemical Biology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- An Open-label Randomized Phase 2 study of Durvalumab Alone or in Combination with Tremelimumab in Patients with Advanced Germ Cell Tumors (APACHE): Results from the First Planned Interim Analysis
- (2018) Andrea Necchi et al. EUROPEAN UROLOGY
- A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth
- (2018) Aalia Batool et al. Cell Death & Disease
- Molecular Mechanisms of Cisplatin Chemoresistance and Its Circumventing in Testicular Germ Cell Tumors
- (2018) Silvia Schmidtova et al. Current Oncology Reports
- 5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells
- (2018) Christoph Oing et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- DNA methylation profiling as a tool for testicular germ cell tumors subtyping
- (2018) Ana L Costa et al. Epigenomics
- The Emerging Role of Epitranscriptomics in Cancer: Focus on Urological Tumors
- (2018) João Lobo et al. Genes
- The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors
- (2018) João Lobo et al. Cancers
- Histone Deacetylase Inhibitors as Anticancer Drugs
- (2017) Tomas Eckschlager et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)
- (2017) Matthias Schiedel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study
- (2017) Nico van Zandwijk et al. LANCET ONCOLOGY
- Animacroxam, a Novel Dual-Mode Compound Targeting Histone Deacetylases and Cytoskeletal Integrity of Testicular Germ Cell Cancer Cells
- (2017) Gustav Steinemann et al. MOLECULAR CANCER THERAPEUTICS
- Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation
- (2017) Martina Benešová et al. MOLECULAR CARCINOGENESIS
- Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
- (2017) Kevin Litchfield et al. NATURE GENETICS
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- The epigenetics of testicular germ cell tumors: looking for novel disease biomarkers
- (2017) Ana Laura Costa et al. Epigenomics
- The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo
- (2016) Sina Jostes et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Repurposing the CRISPR-Cas9 system for targeted DNA methylation
- (2016) Aleksandar Vojta et al. NUCLEIC ACIDS RESEARCH
- A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment
- (2016) Daniel Nettersheim et al. Oncotarget
- MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients
- (2016) Camila Maria da Silva Martinelli et al. Oncotarget
- Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine
- (2016) Costantine Albany et al. Oncotarget
- microRNA Therapeutics in Cancer — An Emerging Concept
- (2016) Maitri Y. Shah et al. EBioMedicine
- Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death
- (2015) U Beyer et al. CELL DEATH AND DIFFERENTIATION
- Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors
- (2015) Cassy M. Spiller et al. Molecular Oncology
- Chromatin Remodelers: From Function to Dysfunction
- (2015) Gernot Längst et al. Genes
- Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries
- (2015) Patompon Wongtrakoongate World Journal of Stem Cells
- Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors
- (2015) Martin A. Rijlaarsdam et al. PLoS One
- Anti-neoplastic properties of hydralazine in prostate cancer
- (2015) Inês Graça et al. Oncotarget
- Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote
- (2014) Fan Guo et al. Cell Stem Cell
- Cisplatin resistance in germ cell tumours: models and mechanisms
- (2014) C. Jacobsen et al. Andrology
- LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels
- (2013) M. J. Murray et al. CANCER RESEARCH
- Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application
- (2013) Ludmila Boublikova et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer
- (2013) Bi-Feng Chen et al. Epigenetics
- The future of epigenetic therapy in solid tumours—lessons from the past
- (2013) Nilofer Azad et al. Nature Reviews Clinical Oncology
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development
- (2013) Daniel Nettersheim et al. PLoS One
- Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
- (2012) Li Shen et al. PLoS One
- Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation
- (2012) Bijesh K. Biswal et al. PLoS One
- DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma
- (2011) M Brait et al. BRITISH JOURNAL OF CANCER
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
- (2011) Daniel Nettersheim et al. GENES CHROMOSOMES & CANCER
- Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes
- (2011) Ulrike Beyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of Human Endogenous Retroviral Long Terminal Repeats (LTRs) in Maintaining the Integrity of the Human Germ Line
- (2011) Meihong Liu et al. Viruses-Basel
- Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
- (2010) K Almstrup et al. BRITISH JOURNAL OF CANCER
- Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
- (2010) Helen J. Mackay et al. EUROPEAN JOURNAL OF CANCER
- Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines
- (2010) R. Lambrot et al. INTERNATIONAL JOURNAL OF ANDROLOGY
- Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance
- (2010) Hendrik Wermann et al. JOURNAL OF PATHOLOGY
- Targeting DNA methylation for epigenetic therapy
- (2010) Xiaojing Yang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
- (2009) N Steele et al. BRITISH JOURNAL OF CANCER
- High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors
- (2009) M. J. Beyrouthy et al. CANCER RESEARCH
- Sunitinib Inhibits Tumor Growth and Synergizes with Cisplatin in Orthotopic Models of Cisplatin-Sensitive and Cisplatin-Resistant Human Testicular Germ Cell Tumors
- (2009) W. Castillo-Avila et al. CLINICAL CANCER RESEARCH
- Therapeutic Potential of Mdm2 Inhibition in Malignant Germ Cell Tumours
- (2009) Sebastian Bauer et al. EUROPEAN UROLOGY
- Microsatellite Instability, Mismatch Repair Deficiency, andBRAFMutation in Treatment-Resistant Germ Cell Tumors
- (2009) Friedemann Honecker et al. JOURNAL OF CLINICAL ONCOLOGY
- Deregulation of EZH2 expression in human spermatogenic disorders and testicular germ cell tumors
- (2009) Stefan Hinz et al. WORLD JOURNAL OF UROLOGY
- Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
- (2008) Ashley R. Schneekloth et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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