Germline genome protection: implications for gamete quality and germ cell tumorigenesis

Mutations causing specific arrests in the development of mouse primordial germ cells and gonocytes

(2018) Geert Hamer et al.   BIOLOGY OF REPRODUCTION

Spermatogonial stem cells and spermatogenesis in mice, monkeys and men

(2018) Adetunji P. Fayomi et al.   Stem Cell Research

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate

(2018) Julia Tischler et al.   EMBO JOURNAL

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

A tough row to hoe: when replication forks encounter DNA damage

(2018) Darshil R. Patel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Testicular cancer

(2018) Liang Cheng et al.   Nature Reviews Disease Primers

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

(2017) Masashi Yamaji et al.   NATURE

Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells

(2017) Yohei Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity

(2017) Samuel G. Awuah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

(2017) Christiane Rudolph et al.   CELLULAR ONCOLOGY

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer

(2017) Timothy M. Pierpont et al.   Cell Reports

Global Hypertranscription in the Mouse Embryonic Germline

(2017) Michelle Percharde et al.   Cell Reports

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death

(2017) Vera D. Rinaldi et al.   GENETICS

Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation

(2016) Joseph Hargan-Calvopina et al.   DEVELOPMENTAL CELL

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells

(2016) Kiyoko Setoguchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Genomic evolution and chemoresistance in germ-cell tumours

(2016) Amaro Taylor-Weiner et al.   NATURE

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

Lysine methylation represses p53 activity in teratocarcinoma cancer cells

(2016) Jiajun Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells

(2016) Norikatsu Miyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primordial Germ Cells: Current Knowledge and Perspectives

(2016) Aleksandar Nikolic et al.   Stem Cells International

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling

(2015) Irina I. Suvorova et al.   CELL CYCLE

MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway

(2015) Yunhai Luo et al.   GENESIS

MCM9 Is Required for Mammalian DNA Mismatch Repair

(2015) Sabine Traver et al.   MOLECULAR CELL

In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells

(2015) W Ge et al.   Cell Death & Disease

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours

(2015) Kevin Litchfield et al.   Nature Communications

Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress

(2015) Xin Quan Ge et al.   Stem Cell Reports

Cancer treatment and survivorship statistics, 2014

(2014) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti-tumor barrier concept and treatment

(2014) Jirina Bartkova et al.   Molecular Oncology

Cisplatin Induces Resistance by Triggering Differentiation of Testicular Embryonal Carcinoma Cells

(2014) Paolo B. Abada et al.   PLoS One

Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway

(2014) E. Bolcun-Filas et al.   SCIENCE

Hypersensitivity of Primordial Germ Cells to Compromised Replication-Associated DNA Repair Involves ATM-p53-p21 Signaling

(2014) Yunhai Luo et al.   PLoS Genetics

Cisplatin resistance in germ cell tumours: models and mechanisms

(2014) C. Jacobsen et al.   Andrology

The Trp53 - Trp53inp1 - Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells

(2014) Kei Ishii et al.   Stem Cell Reports

Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1

(2013) Martine Culty   BIOLOGY OF REPRODUCTION

Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4

(2013) M. Gutekunst et al.   CANCER RESEARCH

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

(2013) Julia C. Liu et al.   Cell Stem Cell

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

(2012) Raluca Dumitru et al.   MOLECULAR CELL

Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation

(2012) Bijesh K. Biswal et al.   PLoS One

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

(2012) Francesca Cavallo et al.   PLoS One

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Mismatch and base excision repair proficiency in murine embryonic stem cells

(2011) Elisia D. Tichy et al.   DNA REPAIR

p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to Cisplatin

(2011) Matthias Gutekunst et al.   PLoS One

Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells

(2010) Claudia E. Rübe et al.   DNA REPAIR

Suppression of Rev3, the catalytic subunit of Pol , sensitizes drug-resistant lung tumors to chemotherapy

(2010) J. Doles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1Ter/Ter mice

(2009) Matthew S. Cook et al.   DEVELOPMENTAL BIOLOGY

Etiologic factors in testicular germ-cell tumors

(2009) Katherine A McGlynn et al.   Future Oncology

Survival responses of human embryonic stem cells to DNA damage

(2009) Tera M. Filion et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules

(2009) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA repair in murine embryonic stem cells and differentiated cells

(2008) Elisia D. Tichy et al.   EXPERIMENTAL CELL RESEARCH

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE