Epigenetic treatment combinations to effectively target cisplatin‐resistant germ cell tumors‐past, present, and future considerations
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Title
Epigenetic treatment combinations to effectively target cisplatin‐resistant germ cell tumors‐past, present, and future considerations
Authors
Keywords
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Journal
Andrology
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-03-29
DOI
10.1111/andr.12611
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Note: Only part of the references are listed.- Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition
- (2019) Praveen Rajendran et al. CANCER RESEARCH
- Biological and molecular effects of bromodomain and extra-terminal (BET) inhibitors JQ1, IBET-151 and IBET-762 in OSCC cells
- (2019) Federica Baldan et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses
- (2018) Daniela Matei et al. CLINICAL CANCER RESEARCH
- Therapeutic approaches for refractory germ cell cancer
- (2018) Christoph Oing et al. Expert Review of Anticancer Therapy
- Epigenetics and testicular germ cell tumors
- (2018) Robert Buljubašić et al. GENE
- Targeting bromodomain and extraterminal proteins in breast cancer
- (2018) Jennifer M. Sahni et al. PHARMACOLOGICAL RESEARCH
- EP-1618: Monoubiquitinylated histone H2B as a potential target in treatment resistant germ cell tumors
- (2018) C. Oing et al. RADIOTHERAPY AND ONCOLOGY
- Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
- (2018) Jay H. Kalin et al. Nature Communications
- Integrated Molecular Characterization of Testicular Germ Cell Tumors
- (2018) Hui Shen et al. Cell Reports
- Drug Design Concepts for LSD1-Selective Inhibitors
- (2018) Yosuke Ota et al. CHEMICAL RECORD
- An Open-label Randomized Phase 2 study of Durvalumab Alone or in Combination with Tremelimumab in Patients with Advanced Germ Cell Tumors (APACHE): Results from the First Planned Interim Analysis
- (2018) Andrea Necchi et al. EUROPEAN UROLOGY
- Everolimus in patients with multiply relapsed or cisplatin refractory germ cell tumors: results of a phase II, single-arm, open-label multicenter trial (RADIT) of the German Testicular Cancer Study Group
- (2018) Martin Fenner et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Recent global trends in testicular cancer incidence and mortality
- (2018) Jee Soo Park et al. MEDICINE
- Palliative treatment of germ cell cancer
- (2018) Christoph Oing et al. CANCER TREATMENT REVIEWS
- 5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells
- (2018) Christoph Oing et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors
- (2018) Daniel Nettersheim et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
- (2018) Wei Meng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Pharmacological Inhibition of LSD1 for Cancer Treatment
- (2018) Guan-Jun Yang et al. MOLECULES
- Preclinical Studies Support Combined Inhibition of BET Family Proteins and Histone Deacetylases as Epigenetic Therapy for Cutaneous T-Cell Lymphoma
- (2018) Lei Zhao et al. NEOPLASIA
- Response to anti-programmed cell death protein-1 antibodies in men treated for platinum refractory germ cell cancer relapsed after high-dose chemotherapy and stem cell transplantation
- (2017) Stefanie Zschäbitz et al. EUROPEAN JOURNAL OF CANCER
- Bromodomain Histone Readers and Cancer
- (2017) Abhinav K Jain et al. JOURNAL OF MOLECULAR BIOLOGY
- Animacroxam, a Novel Dual-Mode Compound Targeting Histone Deacetylases and Cytoskeletal Integrity of Testicular Germ Cell Cancer Cells
- (2017) Gustav Steinemann et al. MOLECULAR CANCER THERAPEUTICS
- Tumor Mutational Burden and Response Rate to PD-1 Inhibition
- (2017) Mark Yarchoan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer
- (2017) Dennis O. Adeegbe et al. Cancer Discovery
- Targeting Cancer Cells with BET Bromodomain Inhibitors
- (2017) Yali Xu et al. Cold Spring Harbor Perspectives in Medicine
- Epigenetic Therapeutics: A New Weapon in the War Against Cancer
- (2016) Nita Ahuja et al. Annual Review of Medicine
- The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas
- (2016) Daniel Nettersheim et al. BRITISH JOURNAL OF CANCER
- Combining Epigenetic and Immunotherapy to Combat Cancer
- (2016) Katherine B. Chiappinelli et al. CANCER RESEARCH
- The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects
- (2016) J. Shahbazi et al. CLINICAL CANCER RESEARCH
- Germ cell neoplasiain situ(GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy
- (2016) Daniel M Berney et al. HISTOPATHOLOGY
- The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo
- (2016) Sina Jostes et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors
- (2016) Aditya Bagrodia et al. JOURNAL OF CLINICAL ONCOLOGY
- Testicular germ cell tumours
- (2016) Ewa Rajpert-De Meyts et al. LANCET
- BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells
- (2016) D T Saenz et al. LEUKEMIA
- Phase II study of everolimus in refractory testicular germ cell tumors
- (2016) Michal Mego et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment
- (2016) Daniel Nettersheim et al. Oncotarget
- Targeting BET bromodomain proteins in solid tumors
- (2016) Vaibhav Sahai et al. Oncotarget
- Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine
- (2016) Costantine Albany et al. Oncotarget
- Epigenetic polypharmacology: from combination therapy to multitargeted drugs
- (2016) Angel R. de Lera et al. Clinical Epigenetics
- Clinical Response of a Patient to Anti-PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors
- (2016) S. Shah et al. Cancer Immunology Research
- Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death
- (2015) U Beyer et al. CELL DEATH AND DIFFERENTIATION
- Digging deep into “dirty” drugs – modulation of the methylation machinery
- (2015) Lisa Pleyer et al. DRUG METABOLISM REVIEWS
- Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors
- (2015) Cassy M. Spiller et al. Molecular Oncology
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
- (2015) Pawel K Mazur et al. NATURE MEDICINE
- The effects of chemotherapy with bleomycin, etoposide, and cis-platinum on telomeres in rat male germ cells
- (2015) M. Liu et al. Andrology
- Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors
- (2015) Martin A. Rijlaarsdam et al. PLoS One
- Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives
- (2014) P Wongtrakoongate et al. BRITISH JOURNAL OF CANCER
- Presence of Somatic Mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in Cisplatin-Resistant Germ Cell Tumors
- (2014) D. R. Feldman et al. CLINICAL CANCER RESEARCH
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines
- (2014) Yvonne G. van der Zwan et al. PLoS One
- Cisplatin resistance in germ cell tumours: models and mechanisms
- (2014) C. Jacobsen et al. Andrology
- The Effects of Chemotherapy with Bleomycin, Etoposide, and Cis-Platinum (BEP) on Rat Sperm Chromatin Remodeling, Fecundity and Testicular Gene Expression in the Progeny1
- (2013) Jennifer Maselli et al. BIOLOGY OF REPRODUCTION
- The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors
- (2013) M. Juliachs et al. CLINICAL CANCER RESEARCH
- A phase 2 multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors
- (2013) Darren R. Feldman et al. INVESTIGATIONAL NEW DRUGS
- Cancer testis antigen expression in testicular germ cell tumorigenesis
- (2013) Peter K Bode et al. MODERN PATHOLOGY
- Exposure to Bleomycin, Etoposide, and Cis-Platinum Alters Rat Sperm Chromatin Integrity and Sperm Head Protein Profile1
- (2012) Jennifer Maselli et al. BIOLOGY OF REPRODUCTION
- Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability
- (2012) S. B. Chernikova et al. CANCER RESEARCH
- Epigenetic Resensitization to Platinum in Ovarian Cancer
- (2012) D. Matei et al. CANCER RESEARCH
- DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma
- (2012) Eri Arai et al. HISTOPATHOLOGY
- Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma
- (2012) Idriss M. Bennani-Baiti et al. HUMAN PATHOLOGY
- Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation
- (2012) Bijesh K. Biswal et al. PLoS One
- Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: a Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study
- (2011) K. Oechsle et al. ANNALS OF ONCOLOGY
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- NANOG promoter methylation and expression correlation during normal and malignant human germ cell development
- (2011) Daniel Nettersheim et al. Epigenetics
- Long-Term Survival After Treatment with Gemcitabine and Oxaliplatin With and Without Paclitaxel Plus Secondary Surgery in Patients with Cisplatin-Refractory and/or Multiply Relapsed Germ Cell Tumors
- (2011) Karin Oechsle et al. EUROPEAN UROLOGY
- The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
- (2011) Daniel Nettersheim et al. GENES CHROMOSOMES & CANCER
- Prognostic Factors in Patients With Metastatic Germ Cell Tumors Who Experienced Treatment Failure With Cisplatin-Based First-Line Chemotherapy
- (2010) JOURNAL OF CLINICAL ONCOLOGY
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
- (2009) N Steele et al. BRITISH JOURNAL OF CANCER
- High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors
- (2009) M. J. Beyrouthy et al. CANCER RESEARCH
- An operational definition of epigenetics
- (2009) S. L. Berger et al. GENES & DEVELOPMENT
- Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors
- (2009) Darren R. Feldman et al. INVESTIGATIONAL NEW DRUGS
- Microsatellite Instability, Mismatch Repair Deficiency, andBRAFMutation in Treatment-Resistant Germ Cell Tumors
- (2009) Friedemann Honecker et al. JOURNAL OF CLINICAL ONCOLOGY
- Rethinking how DNA methylation patterns are maintained
- (2009) Peter A. Jones et al. NATURE REVIEWS GENETICS
- Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
- (2008) Dawid Eckert et al. BMC DEVELOPMENTAL BIOLOGY
- HDAC family: What are the cancer relevant targets?
- (2008) Olaf Witt et al. CANCER LETTERS
- Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors
- (2008) Georges J Netto et al. MODERN PATHOLOGY
- Epigenetics in Cancer
- (2008) Manel Esteller NEW ENGLAND JOURNAL OF MEDICINE
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