The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype

(2020) Lei Liu et al.   EXPERIMENTAL CELL RESEARCH

Bioactive DNA from extracellular vesicles and particles

(2020) Ethan Z. Malkin et al.   Cell Death & Disease

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

(2019) Wei-Lun Hwang et al.   Journal of Hematology & Oncology

Cancer cells stemness: A doorstep to targeted therapy

(2019) Sahdeo Prasad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

(2019) Wei‐Chung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

(2019) Liu Han et al.   Molecular Cancer

Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts

(2019) Yutaka Naito et al.   ONCOGENE

Crosstalk between cancer and immune cells: Role of tumor-associated macrophages in the tumor microenvironment

(2019) Jing Wang et al.   Cancer Medicine

Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages

(2019) Hao-Yu Chuang et al.   Journal of Clinical Medicine

Glioblastoma Stem Cell-Derived Exosomes Enhance Stemness and Tumorigenicity of Glioma Cells by Transferring Notch1 Protein

(2019) Zhen Sun et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

(2019) Jia-Hong Chen et al.   Cancers

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

Exosome-Mediated Regulation of Tumor Immunology

(2018) Naohiro Seo et al.   CANCER SCIENCE

Long-Range Function of Secreted Small Nucleolar RNAs that Direct 2'-O-Methylation

(2018) Jamie M. Rimer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid cancer stem-like cell exosomes: regulation of EMT via transfer of lncRNAs

(2018) Heather Hardin et al.   LABORATORY INVESTIGATION

Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

(2018) Mohammad Rumman et al.   Stem Cell Research

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

(2018) Jing Ren et al.   Theranostics

Gram-Positive Bacterial Extracellular Vesicles and Their Impact on Health and Disease

(2018) Yue Liu et al.   Frontiers in Microbiology

Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p

(2018) Hongdan Li et al.   BRITISH JOURNAL OF CANCER

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis

(2018) C. Probert et al.   ONCOGENE

Cancer incidence increasing globally: The role of relaxed natural selection

(2017) Wenpeng You et al.   Evolutionary Applications

Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression

(2017) Lei Pan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

(2017) Jiahui Mao et al.   STEM CELLS

Leukemia microvesicles affect healthy hematopoietic stem cells

(2017) Farnaz Razmkhah et al.   TUMOR BIOLOGY

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

Determining the contents and cell origins of apoptotic bodies by flow cytometry

(2017) Lanzhou Jiang et al.   Scientific Reports

Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway

(2016) Hongbing Gu et al.   Molecular Medicine Reports

Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment

(2016) Valery Vilchez   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer

(2015) Ramkishore Gernapudi et al.   BREAST CANCER RESEARCH AND TREATMENT

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

(2015) Amber Jin Giles et al.   CANCER RESEARCH

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells

(2015) Ronghua Wang et al.   Oncotarget

Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells

(2013) Qinglin Li et al.   BREAST CANCER RESEARCH AND TREATMENT

 -Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression

(2013) B. Schade et al.   CANCER RESEARCH

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Prostasomes: extracellular vesicles from the prostate

(2013) Marian Aalberts et al.   REPRODUCTION

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Beyond PSA: The Next Generation of Prostate Cancer Biomarkers

(2012) J. R. Prensner et al.   Science Translational Medicine

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

(2008) Frank J. T. Staal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY