Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages

Momelotinib sensitizes glioblastoma cells to temozolomide by enhancement of autophagy via JAK2/STAT3 inhibition

(2019) Tie Liu et al.   ONCOLOGY REPORTS

Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model

(2019) Benedikt Linder et al.   Cancers

PD-1/PD-L1 immune-checkpoint inhibitors in glioblastoma: A concise review

(2019) Mario Caccese et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Brain-Cortex Microglia-Derived Exosomes: Nanoparticles for Glioma Therapy

(2018) Adriana-Natalia Murgoci et al.   CHEMPHYSCHEM

Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia

(2018) Na Chen et al.   ONCOLOGY REPORTS

Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation

(2018) Brian C. Betts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma

(2018) Debolina Ganguly et al.   Oncotarget

Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis

(2018) John Mascarenhas et al.   JAMA Oncology

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line

(2017) Yasuto Akiyama et al.   IMMUNOLOGY LETTERS

MiR-21: A key player in glioblastoma pathogenesis

(2017) Mohammad Sadegh Masoudi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

(2017) Soliman Oushy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

STAT3-mediated activation of miR-21 is involved in downregulation of TIMP3 and neovascularization in the ischemic retina

(2017) Diana R. Gutsaeva et al.   Oncotarget

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells

(2017) Yufang Ma et al.   Stem Cell Reports

B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients

(2016) Y. Yao et al.   CLINICAL CANCER RESEARCH

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

(2015) Gang Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma

(2014) Robert L Bowman et al.   Immunotherapy

Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line

(2014) TADASHI ASHIZAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

(2014) Matteo Forloni et al.   eLife

Sequence-Dependent Synergistic Inhibition of Human Glioma Cell Lines by Combined Temozolomide and miR-21 Inhibitor Gene Therapy

(2012) Xiaomin Qian et al.   MOLECULAR PHARMACEUTICS

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

(2012) Owen D. Stechishin et al.   NEURO-ONCOLOGY

Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion

(2012) Barbara Ortensi et al.   STEM CELLS

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model

(2009) Gagliano   ONCOLOGY REPORTS

Proliferation of Human Glioblastoma Stem Cells Occurs Independently of Exogenous Mitogens

(2009) John J. P. Kelly et al.   STEM CELLS

Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

(2008) M. A. Harris et al.   CANCER RESEARCH

PDCD4gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis

(2008) Fei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY