Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids

A new genomic blueprint of the human gut microbiota

(2019) Alexandre Almeida et al.   NATURE

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

(2019) Annika Wyss et al.   Mucosal Immunology

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

Group 3 ILCs: Peacekeepers or Troublemakers? What's Your Gut Telling You?!

(2019) Eirini Pantazi et al.   Frontiers in Immunology

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research

(2019) M. Poyet et al.   NATURE MEDICINE

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

Modeling metabolism of the human gut microbiome

(2018) Stefanía Magnúsdóttir et al.   CURRENT OPINION IN BIOTECHNOLOGY

Oxysterols in intestinal immunity and inflammation

(2018) T. Willinger   JOURNAL OF INTERNAL MEDICINE

Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors

(2018) Adam J. Meyer et al.   Nature Chemical Biology

Interplay of innate lymphoid cells and the microbiota

(2017) Liudmila Britanova et al.   IMMUNOLOGICAL REVIEWS

Natural product discovery from the human microbiome

(2017) Matthew R. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Commensal bacteria make GPCR ligands that mimic human signalling molecules

(2017) Louis J. Cohen et al.   NATURE

N -oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms

(2017) Olga A. Sergeeva et al.   NEUROPHARMACOLOGY

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

EndogenousN-acyl taurines regulate skin wound healing

(2016) Oscar Sasso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polypharmacology of dopamine receptor ligands

(2016) S. Butini et al.   PROGRESS IN NEUROBIOLOGY

Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health

(2016) Pamela Vernocchi et al.   Frontiers in Microbiology

The Gut Microbiota in Immune-Mediated Inflammatory Diseases

(2016) Jessica D. Forbes et al.   Frontiers in Microbiology

MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome

(2015) Stephen Nayfach et al.   BIOINFORMATICS

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Trace amine-associated receptors: ligands, neural circuits, and behaviors

(2015) Stephen D Liberles   CURRENT OPINION IN NEUROBIOLOGY

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

(2015) Louis J. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults

(2015) Salma A. Abdelmagid et al.   PLoS One

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor

(2014) Francois Gessier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relating the metatranscriptome and metagenome of the human gut

(2014) E. A. Franzosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

(2014) Siham Raboune et al.   Frontiers in Cellular Neuroscience

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease

(2013) Lael Werner et al.   Theranostics

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

(2013) Laura C. Wieland Brown et al.   PLOS BIOLOGY

Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation

(2013) Tau Benned-Jensen et al.   FEBS Open Bio

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

(2012) Yasunari Asano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High Selectivity of the γ-Aminobutyric Acid Transporter 2 (GAT-2, SLC6A13) Revealed by Structure-based Approach

(2012) Avner Schlessinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Composition IncludingTrans-Fatty Acids in Edible Oils and Fats: Probable Intake in Indian Population

(2012) Sumita Dixit et al.   JOURNAL OF FOOD SCIENCE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

(2012) Jürgen Glas et al.   PLoS One

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Fatty acid amide signaling molecules

(2010) Cyrine Ezzili et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator

(2010) X Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine

(2009) Hamish R Ross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

(2009) Zhi-Liang Chu et al.   MOLECULAR ENDOCRINOLOGY

Critical Evaluation of Two Primers Commonly Used for Amplification of Bacterial 16S rRNA Genes

(2008) J. A. Frank et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis, degradation and pharmacological importance of the fatty acid amides

(2008) Emma K. Farrell et al.   DRUG DISCOVERY TODAY

Identification of Farnesyl Pyrophosphate andN-Arachidonylglycine as Endogenous Ligands for GPR92

(2008) Da Young Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE