Natural product discovery from the human microbiome

Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth

(2016) Julia S. Martín del Campo et al.   ACS Chemical Biology

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

(2016) Hsu-Hua Yeh et al.   ACS Chemical Biology

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin

(2016) Li Zha et al.   ACS Chemical Biology

Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis

(2016) James Kuo et al.   ACS Chemical Biology

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Natural Product Discovery through Improved Functional Metagenomics in Streptomyces

(2016) Hala A. Iqbal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A

(2016) Alan R. Healy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation

(2016) Hilary P. Browne et al.   NATURE

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

(2016) Zhong-Rui Li et al.   Nature Chemical Biology

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

(2016) John Chu et al.   Nature Chemical Biology

High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue

(2016) Alice Ly et al.   Nature Protocols

Synthetic biology to access and expand nature's chemical diversity

(2016) Michael J. Smanski et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Tools for the Microbiome: Nano and Beyond

(2015) Julie S. Biteen et al.   ACS Nano

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

(2015) Zhong-Rui Li et al.   CHEMBIOCHEM

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

(2015) A. O. Brachmann et al.   CHEMICAL COMMUNICATIONS

A reinvigorated era of bacterial secondary metabolite discovery

(2015) Ashley M Sidebottom et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome

(2015) Robert A Quinn et al.   ISME Journal

Animals in a bacterial world: opportunities for chemical ecology

(2015) Alexandra M. Cantley et al.   NATURAL PRODUCT REPORTS

Colibactin: understanding an elusive gut bacterial genotoxin

(2015) Emily P. Balskus   NATURAL PRODUCT REPORTS

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

(2015) Carolyn A. Brotherton et al.   ORGANIC LETTERS

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

(2015) Jeremy G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

(2015) Louis J. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular cartography of the human skin surface in 3D

(2015) Amina Bouslimani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

In Vitro Reconstitution of Metabolic Pathways: Insights into Nature’s Chemical Logic

(2015) Chaitan Khosla et al.   SYNLETT

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

(2015) Xiaoying Bian et al.   Chemical Science

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Determining Microbial Products and Identifying Molecular Targets in the Human Microbiome

(2014) Regina Joice et al.   Cell Metabolism

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

Metagenomic small molecule discovery methods

(2014) Zachary Charlop-Powers et al.   CURRENT OPINION IN MICROBIOLOGY

Finding the Missing Links among Metabolites, Microbes, and the Host

(2014) Pieter C. Dorrestein et al.   IMMUNITY

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

Metagenomic Approaches for Exploiting Uncultivated Bacteria as a Resource for Novel Biosynthetic Enzymology

(2013) Micheal C. Wilson et al.   CHEMISTRY & BIOLOGY

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents

(2012) Marina Tanasova et al.   CHEMICAL REVIEWS

A framework for human microbiome research

(2012)   NATURE

Genomic approaches to studying the human microbiota

(2012) George M. Weinstock   NATURE

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

(2011) Helena Tlaskalová-Hogenová et al.   Cellular & Molecular Immunology

Bacterial symbionts and natural products

(2011) Jason M. Crawford et al.   CHEMICAL COMMUNICATIONS

ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides

(2011) Damien Dubois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Detecting Novel Associations in Large Data Sets

(2011) D. N. Reshef et al.   SCIENCE

Integrating ‘-omics’ and natural product discovery platforms to investigate metabolic exchange in microbiomes

(2010) Jane Y Yang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Uncultured microorganisms as a source of secondary metabolites

(2010) Kim Lewis et al.   JOURNAL OF ANTIBIOTICS

Metagenomic approaches to natural products from free-living and symbiotic organisms

(2009) Sean F. Brady et al.   NATURAL PRODUCT REPORTS

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons

(2008) N. Rimmerman et al.   MOLECULAR PHARMACOLOGY

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

(2008) Elizabeth S. Sattely et al.   NATURAL PRODUCT REPORTS

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS