Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Basal myokine levels are associated with quality of life and depressed mood in older adults

(2021) Patrick Mucher et al.   PSYCHOPHYSIOLOGY

Sphingolipids in Alzheimer's disease, how can we target them?

(2020) Simone M. Crivelli et al.   ADVANCED DRUG DELIVERY REVIEWS

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

(2020) Guoyao Wu   AMINO ACIDS

Spermidine in dementia

(2020) Thomas Pekar et al.   WIENER KLINISCHE WOCHENSCHRIFT

Metabolite Profiling Revealed That a Gardening Activity Program Improves Cognitive Ability Correlated with BDNF Levels and Serotonin Metabolism in the Elderly

(2020) Sin-Ae Park et al.   International Journal of Environmental Research and Public Health

Molecular Choreography of Acute Exercise

(2020) Kévin Contrepois et al.   CELL

Exercise-induced oxidative stress: Friend or foe?

(2020) Scott K. Powers et al.   Journal of Sport and Health Science

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

(2020) Forugh S. Dafsari et al.   Translational Psychiatry

Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models

(2020) Zhimin Long et al.   Aging-US

Low Volume Acute Multi-Joint Resistance Exercise Elicits a Circulating Brain-Derived Neurotrophic Factor Response but Not a Cathepsin B Response in Well-Trained Men

(2020) Trevor K Johnson et al.   Applied Physiology Nutrition and Metabolism

The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients

(2020) Dariusz Kotlega et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Single Bout of High-intensity Interval Exercise Increases Corticospinal Excitability, Brain-derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males

(2020) Chiara Nicolini et al.   NEUROSCIENCE

Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia

(2020) Jian-wen Xiong et al.   Frontiers in Neuroscience

Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

(2020) Yue Zhao et al.   AGING CELL

Exercise-induced recovery of plasma lipids perturbed by ageing with nanoflow UHPLC-ESI-MS/MS

(2020) Kang Uk Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes

(2020) Chloe Rezola-Pardo et al.   EXPERIMENTAL GERONTOLOGY

Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment

(2020) Xin Ying Chua et al.   Alzheimers Research & Therapy

The Role of Exercise in Management of Mental Health Disorders: An Integrative Review

(2020) Patrick J. Smith et al.   Annual Review of Medicine

Regular Leisure-Time Physical Activity is Effective in Boosting Neurotrophic Factors and Alleviating Menopause Symptoms

(2020) Boram Kim et al.   International Journal of Environmental Research and Public Health

Habitually inactive physically – a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program

(2020) Katarzyna Micielska et al.   PHYSIOLOGY & BEHAVIOR

Roles of myokines in exercise-induced improvement of neuropsychiatric function

(2019) Sujin Kim et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients

(2019) Honglan Wei et al.   BMC Nephrology

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD

(2019) Claire M. Erickson et al.   NEUROLOGY

Plasma metabolomics in early Alzheimer's disease patients diagnosed with amyloid biomarker

(2019) Carmen Peña-Bautista et al.   Journal of Proteomics

Metabolomics and proteomics profiles of some medicinal plants and correlation with BDNF activity

(2019) Ekrem M. Gonulalan et al.   PHYTOMEDICINE

Exercise and Hippocampal Memory Systems

(2019) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Effect of Aerobic Exercise on Serum Metabolites in Mice with Hepatocellular Carcinoma After Surgery

(2019) Tong Zhao et al.   MEDICAL SCIENCE MONITOR

Gross Motor Skills Training Leads to Increased Brain-Derived Neurotrophic Factor Levels in Healthy Older Adults: A Pilot Study

(2019) Catherine-Alexandra Grégoire et al.   Frontiers in Physiology

Exercise training increases the S-Klotho plasma levels in sedentary middle-aged adults: A randomised controlled trial. The FIT-AGEING study

(2019) F. J. Amaro-Gahete et al.   JOURNAL OF SPORTS SCIENCES

Physical Activity, Cognition, and Brain Outcomes

(2019) KIRK I. ERICKSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Lentiviral vector–mediated overexpression of Klotho in the brain improves Alzheimer's disease–like pathology and cognitive deficits in mice

(2019) Chen-Ye Zeng et al.   NEUROBIOLOGY OF AGING

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

(2019) Md. Jakaria et al.   Redox Biology

Acute and regular exercise distinctly modulate serum, plasma and skeletal muscle BDNF in the elderly

(2019) Denisa Máderová et al.   NEUROPEPTIDES

Muscle metabolism and atrophy: let’s talk about sex

(2019) Megan E. Rosa-Caldwell et al.   Biology of Sex Differences

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome

(2018) Chitra Lal et al.   Sleep and Breathing

Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits

(2018) Fereidoon Shahidi et al.   Annual Review of Food Science and Technology

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders

(2018) Alba Di Pardo et al.   Frontiers in Neuroscience

The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity

(2018) Gregory Hook et al.   JOURNAL OF ALZHEIMERS DISEASE

Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes

(2018) Carla Manuela Crispim Nascimento et al.   JOURNAL OF ALZHEIMERS DISEASE

Next-generation biomarker discovery in Alzheimer's disease using metabolomics – from animal to human studies

(2018) Marina Ollé Hurtado et al.   Bioanalysis

Aerobic exercise‑stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney

(2018) Naichun Ji et al.   Experimental and Therapeutic Medicine

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

(2018) Miranka Wirth et al.   CORTEX

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

(2017) Joseph M. Pickard et al.   IMMUNOLOGICAL REVIEWS

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exercise Modifies the Gut Microbiota with Positive Health Effects

(2017) Vincenzo Monda et al.   Oxidative Medicine and Cellular Longevity

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

(2017) Grace Y. Sun et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Endurance training selectively increases high-density lipoprotein-bound sphingosine-1-phosphate in the plasma

(2017) M. Książek et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice

(2017) Julio Leon et al.   Cell Reports

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

(2017) Anne S. B. Olsen et al.   Open Biology

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

(2017) Zsolt Radak et al.   Redox Biology

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression

(2016) Lanxiang Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Can physical exercise in old age improve memory and hippocampal function?

(2016) Emrah Duzel et al.   BRAIN

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

(2016) Christine M Embury et al.   Journal of Neuroimmune Pharmacology

Metabolites Associated With Circulating Interleukin-6 in Older Adults

(2016) Michael S. Lustgarten et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease

(2016) Jessay Gopuran Devassy et al.   Advances in Nutrition

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study

(2015) Michelle Shardell et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Analytes and Metabolites Associated with Muscle Quality in Young, Healthy Adults

(2015) MICHAEL S. LUSTGARTEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes

(2015) Takhar Kasumov et al.   Obesity

Longevity factor klotho and chronic psychological stress

(2015) A A Prather et al.   Translational Psychiatry

Influence of Aerobic Training and Detraining on Serum BDNF, Insulin Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With Metabolic Syndrome

(2014) Arsalan Damirchi et al.   CLINICAL JOURNAL OF SPORT MEDICINE

Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner

(2014) Marcin Baranowski et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

BDNF mediates improvements in executive function following a 1-year exercise intervention

(2014) Regina L. Leckie et al.   Frontiers in Human Neuroscience

Ultramarathon Run Markedly Reduces Plasma Sphingosine-1-phosphate Concentration

(2014) Marcin Baranowski et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Vascular hippocampal plasticity after aerobic exercise in older adults

(2014) A Maass et al.   MOLECULAR PSYCHIATRY

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Long term habitual exercise is associated with lower resting level of serum BDNF

(2014) Parvin Babaei et al.   NEUROSCIENCE LETTERS

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

Skeletal muscle as a regulator of the longevity protein, Klotho

(2014) Keith G. Avin et al.   Frontiers in Physiology

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women

(2013) Tomoko Matsubara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Recent advances in the application of metabolomics to Alzheimer's Disease

(2013) Eugenia Trushina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Executive Function Changes before Memory in Preclinical Alzheimer’s Pathology: A Prospective, Cross-Sectional, Case Control Study

(2013) Michael G. Harrington et al.   PLoS One

The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review

(2013) T. Huang et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

(2013) Steffany A. L. Bennett et al.   Frontiers in Physiology

Neurobiological markers of exercise-related brain plasticity in older adults

(2012) Michelle W. Voss et al.   BRAIN BEHAVIOR AND IMMUNITY

Plasma Methionine Sulfoxide in Persons with Familial Alzheimer’s Disease Mutations

(2012) John M. Ringman et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism

(2012) J. A. Luther et al.   JOURNAL OF NEUROPHYSIOLOGY

Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults

(2012) O. C. Okonkwo et al.   NEUROLOGY

The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO2max performance in healthy college men

(2012) Hyun-chul Cho et al.   NEUROSCIENCE LETTERS

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise, brain, and cognition across the life span

(2011) Michelle W. Voss et al.   JOURNAL OF APPLIED PHYSIOLOGY

Elevated Plasma Ceramides in Depression

(2011) P. Gracia-Garcia et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phospholipidomic Analysis of All Defined Human Plasma Lipoproteins

(2011) Monireh Dashti et al.   Scientific Reports

Quantitative and Wide-Ranging Profiling of Phospholipids in Human Plasma by Two-dimensional Liquid Chromatography/Mass Spectrometry

(2010) Yoshiaki Sato et al.   ANALYTICAL CHEMISTRY

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

(2010) Yuji Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men

(2010) Seung Ho Jung et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Blood BDNF concentrations reflect brain-tissue BDNF levels across species

(2010) Anders B. Klein et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

An examination of serotonin and psychological variables in the relationship between exercise and mental health

(2009) B. Wipfli et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum sphingomyelins and ceramides are early predictors of memory impairment

(2008) Michelle M. Mielke et al.   NEUROBIOLOGY OF AGING

Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women

(2008) James Currie et al.   NEUROSCIENCE LETTERS

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS