Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro

(2016) C. Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Association of fish oil supplement use with preservation of brain volume and cognitive function

(2015) Lori A. Daiello et al.   Alzheimers & Dementia

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an A?23-35-Induced Alzheimer's Disease Rat Model

(2015) Mei-Hua Qu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

(2015) Edmond Teng et al.   NEUROBIOLOGY OF DISEASE

Omega-3 fatty acids intake and risks of dementia and Alzheimer's disease: A meta-analysis

(2015) Shunquan Wu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

(2014) Manuel Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dementia and Cognitive Impairment

(2014) Julie Hugo et al.   CLINICS IN GERIATRIC MEDICINE

Etiology and Pathogenesis of Late-Onset Alzheimer’s Disease

(2014) Brian J. Balin et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Elevated levels of pro-inflammatory oxylipins in older subjects are normalized by flaxseed consumption

(2014) Stephanie P.B. Caligiuri et al.   EXPERIMENTAL GERONTOLOGY

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

(2014) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

Pathways to Alzheimer's disease

(2014) J. Hardy et al.   JOURNAL OF INTERNAL MEDICINE

Primary Prevention of Alzheimer's Disease: Is It an Attainable Goal?

(2014) Jee-Young Han et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

(2014) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Providing male rats deficient in iron and n-3 fatty acids with iron and alpha-linolenic acid alone affects brain serotonin and cognition differently from combined provision

(2014) Jeannine Baumgartner et al.   Lipids in Health and Disease

Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

(2014) Neal D. Barnard et al.   NEUROBIOLOGY OF AGING

Nutrition and the brain: what advice should we give?

(2014) James K. Cooper   NEUROBIOLOGY OF AGING

Linolenic Acid Provides Multi-cellular Protective Effects After Photothrombotic Cerebral Ischemia in Rats

(2014) Yang Liu et al.   NEUROCHEMICAL RESEARCH

Vitamin D and the risk of dementia and Alzheimer disease

(2014) T. J. Littlejohns et al.   NEUROLOGY

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer’s disease following 2-hydroxy-DHA treatment

(2013) Maria A. Fiol-deRoque et al.   BIOGERONTOLOGY

Diet, cognition, and Alzheimer’s disease: food for thought

(2013) Ane Otaegui-Arrazola et al.   EUROPEAN JOURNAL OF NUTRITION

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of n-3 Polyunsaturated Fatty Acid Therapy on Plasma Inflammatory Markers and N-Terminal Pro-brain Natriuretic Peptide in Elderly Patients with Chronic Heart Failure

(2013) YT Zhao et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

(2013) Anthony F. Domenichiello et al.   JOURNAL OF LIPID RESEARCH

Dietary Linoleic Acid and α-Linolenic Acid Differentially Affect Renal Oxylipins and Phospholipid Fatty Acids in Diet-Induced Obese Rats

(2013) Stephanie P. B. Caligiuri et al.   JOURNAL OF NUTRITION

EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials

(2013) Julian G Martins   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Natural resolution of inflammation

(2013) Marcelo O. Freire et al.   PERIODONTOLOGY 2000

Alzheimer's Disease

(2013) Carly Oboudiyat et al.   SEMINARS IN NEUROLOGY

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

EPA and DHA Differentially Affect In Vitro Inflammatory Cytokine Release by Peripheral Blood Mononuclear Cells from Alzheimer’s Patients

(2012) Simona Serini et al.   Current Alzheimer Research

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

(2012) Nicolas G. Bazan et al.   EXPERIMENTAL NEUROLOGY

Lipidomics of oxidized polyunsaturated fatty acids

(2012) Karen A. Massey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe

(2012) C. Samieri et al.   NEUROLOGY

Tau as a therapeutic target in neurodegenerative disease

(2012) Diana S. Himmelstein et al.   PHARMACOLOGY & THERAPEUTICS

Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

(2012) Virginie F. Labrousse et al.   PLoS One

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation

(2012) Sarah K. Orr et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis

(2012) Dong Suzhen et al.   Translational Neurodegeneration

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- 

(2011) K. H. Weylandt et al.   CARCINOGENESIS

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

(2011) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

(2011) Paula Grammas   Journal of Neuroinflammation

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice

(2011) Dany Arsenault et al.   PLoS One

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats

(2011) Michio Hashimoto et al.   Food & Function

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

(2010) Karin Yurko-Mauro et al.   Alzheimers & Dementia

Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults

(2010) Nick Kalogeropoulos et al.   CLINICA CHIMICA ACTA

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Animal models of amyloid-β-related pathologies in Alzheimer’s disease

(2010) Ola Philipson et al.   FEBS Journal

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

(2010) Ramin Farzaneh-Far   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An α-Linolenic Acid-Rich Formula Reduces Oxidative Stress and Inflammation by Regulating NF-κB in Rats with TNBS-Induced Colitis

(2010) Aktham Hassan et al.   JOURNAL OF NUTRITION

Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids

(2010) Dah-Yuu Lu et al.   NEUROPSYCHOPHARMACOLOGY

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

Polyunsaturated fatty acids, neuroinflammation and well being

(2010) Sophie Layé   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke

(2010) Ludmila Belayev et al.   Translational Stroke Research

The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study

(2010) Yael Richter   Clinical Interventions in Aging

The ADCS valproate neuroprotection trial: Primary efficacy and safety results

(2009) Pierre N. Tariot et al.   Alzheimers & Dementia

Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk

(2009) Elizabeth E Devore et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

(2009) Bruno Vellas et al.   Current Alzheimer Research

The Anti-Inflammatory and Proresolving Mediator Resolvin E1 Protects Mice from Bacterial Pneumonia and Acute Lung Injury

(2009) H. Seki et al.   JOURNAL OF IMMUNOLOGY

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Comparative effects of DHA and EPA on cell function

(2009) Renata Gorjão et al.   PHARMACOLOGY & THERAPEUTICS

Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells

(2008) Timothy D. Mickleborough et al.   CLINICAL NUTRITION

Docosahexaenoic acid synthesis from n-3 fatty acid precursors in rat hippocampal neurons

(2008) Terry L. Kaduce et al.   JOURNAL OF NEUROCHEMISTRY

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization

(2008) Véronique De Smedt-Peyrusse et al.   JOURNAL OF NEUROCHEMISTRY

The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid β(1–40)

(2008) Michio Hashimoto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effect of docosahexaenoic acid against brain injury in ischemic rats

(2008) Hung-Chuan Pan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of fish oil on cognitive performance in older subjects: A randomized, controlled trial

(2008) O. van de Rest et al.   NEUROLOGY

Dietary eicosapentaenoic acid and docosahexaenoic acid equally incorporate as decosahexaenoic acid but differ in inflammatory effects

(2008) Saleta Sierra et al.   NUTRITION

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

(2008) Chih-Chiang Chiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1β-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma

(2008) Akiko Kawashima et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH