Growth differentiation factor 15 as a potential therapeutic for treating obesity

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

(2020) Tito Borner et al.   Cell Reports

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

(2020) Ji Sun Moon et al.   AGING CELL

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

(2020) Rowena Suriben et al.   NATURE MEDICINE

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

(2019) Henriette Frikke-Schmidt et al.   Molecular Metabolism

Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study

(2019) Ching-Lung Cheung et al.   EBioMedicine

Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases

(2019) Seung Joon Baek et al.   PHARMACOLOGY & THERAPEUTICS

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

(2018) Marlena S. Fejzo et al.   Nature Communications

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood

(2018) Jiyang Jiang et al.   Frontiers in Genetics

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum

(2018) Marlena Fejzo et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

GDF15 deficiency promotes high fat diet-induced obesity in mice

(2018) Thanhvien Tran et al.   PLoS One

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

(2017) Yumei Xiong et al.   Science Translational Medicine

TGF-β contamination of purified recombinant GDF15

(2017) Oddrun Elise Olsen et al.   PLoS One

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

(2015) V W W Tsai et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

(2015) Vicky Wang-Wei Tsai et al.   PLoS One

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

(2014) Vicky Wang-Wei Tsai et al.   PLoS One

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

(2013) Klaus Unsicker et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?

(2013) Jill Corre et al.   Stem Cells Translational Medicine

Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial

(2012) Tibor Kempf et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats

(2012) Stanka Mihaylova et al.   Journal of Neuroinflammation

The pharmaceutical market for obesity therapies

(2012) Donny Wong et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnostic Accuracy of Maternal Serum Macrophage Inhibitory Cytokine-1 and Pregnancy-Associated Plasma Protein-A at 6–10 Weeks of Gestation to Predict Miscarriage

(2012) Stephen Tong et al.   OBSTETRICS AND GYNECOLOGY

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

(2011) Samuel N. Breit et al.   GROWTH FACTORS

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

(2011) S. N. Breit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

The Relationship between Insulin Resistance and the Cardiovascular Biomarker Growth Differentiation Factor-15 in Obese Patients

(2010) G. Vila et al.   CLINICAL CHEMISTRY

Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15

(2009) J. Strelau et al.   JOURNAL OF NEUROSCIENCE